Objective features of subjective cognitive decline in a United States national database

Kielb, Stephanie; Rogalskı, Emily; Weıntraub, Sandra; Rademaker, Alfred

doi:10.1016/j.jalz.2017.04.008

Cited by 55 publications

(47 citation statements)

References 44 publications

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“…This suggests that objective decline could be detected in those with SCD if more sensitive neuropsychological tests were applied. Consistent with this possibility, some studies have found that older adults with SCD have subtle changes in episodic memory, psychomotor speed, language or executive functions compared to those without SCD [22, 25–27]; however, these subtle cognitive differences are very difficult to capture at the individual level [28], and potential mediating factors such as mood, personality characteristics, and cognitive reserve were not always ruled out in these studies [22]. Although several neuropsychological tests were used to measure objective cognitive performance in the present study, it is possible that a relationship with SCD may have been observed, even after accounting for the relationship between SCD and symptoms of depression, with more sensitive measures of cognition.…”

Section: Discussionmentioning

confidence: 99%

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Zlatar

Muniz

Espinoza

et al. 2018

JAD

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Subjective cognitive decline (SCD) is common in older adults and may be an early marker of future cognitive decline. Research suggest that SCD is more closely related to concurrent symptoms of depression than to objective cognitive performance in non-Hispanic Whites, but it is unknown whether the associations of SCD, cognition, and depression manifest differently in Hispanic older adults. We examined if SCD is associated with objective cognitive performance or with depression symptoms in 145 Hispanic individuals ages 60 or older referred by community health clinics for screening of cognitive complaints. All participants lived near the U.S.-Mexico border, spoke Spanish only, or were Spanish-English bilingual. Memory-only and global cognitive composites were created from scores on Spanish versions of several neuropsychological tests. The Geriatric Depression Scale (GDS) and a five-item SCD questionnaire developed by our group were also completed. Multiple regression analyses showed no significant associations between SCD and memory or global cognitive composite scores after adjusting for age, sex, education, and GDS score. In contrast, there was a significant association between GDS and SCD after adjusting for age, sex, education, global and memory composite scores. Findings suggest that SCD does not accurately reflect current cognitive status in older Hispanics who present to their primary care physician with cognitive complaints. Clinicians should interpret SCD in this population within the context of information about symptoms of depression. Longitudinal research is needed in older Hispanics to better characterize SCD in this population and to determine if it can predict future cognitive decline.

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Section: Discussionmentioning

confidence: 99%

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Zlatar

Muniz

Espinoza

et al. 2018

JAD

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“…Subjective cognitive decline (SCD) refers to a condition that an individual subjectively experienced decline in cognitive function in the absence of evidence for objective cognitive impairment [10]. Mounting evidence suggests that SCD is an early indicator of AD, which subjects with SCD are at high-risk for developing AD [11][12][13]. At the same time, it should be noted that the majority of individuals with SCD will not progress to AD [14].…”

Section: Introductionmentioning

confidence: 99%

Beneficial impact of education on cognition in amyloid-positive individuals with subjective cognitive decline: The SILCODE study

Chen

Liu

Yang

et al. 2020

Preprint

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Background: Previous studies suggest that education is associated with a decreased risk of dementia in individuals with subjective cognitive decline (SCD). However, the influence of education on cognition in amyloid-positive SCD subjects is not clear.Methods: We performed a cross-sectional study that involved 43 amyloid-negative and 29 amyloid-positive SCD subjects from the Sino Longitudinal Study on Cognitive Decline (SILCODE) project. Cognitive assessment included episodic memory, executive function, language, and general cognitive function. Multiple linear regression model was used to assess the association of education on cognitive performance.Results: Multiple linear regression analysis suggested that education has a protective effect on executive function, language for the amyloid-negative SCD group and language, global cognition for the amyloid-positive SCD group.Conclusions: The present study indicated that education has the potential to delay disease progression in amyloid-positive SCD subjects.

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“…Subjective cognitive impairment (SCI) is common in the elderly, and may serve as a symptomatic indicator of a precursor stage of Alzheimer's dementia (AD), even if subtle cognitive decline is difficult to detect on standardized cognitive testing ( Jessen et al, 2014 ). While this condition is not considered to be a definite neurodegenerative process such as mild cognitive impairment (MCI) or AD, it may precede a further cognitive decline and the development of dementia ( Kielb et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional variations of white and grey matter in older hypertensive patients with subjective memory complaints

Chetouani

Chawki

Hossu

et al. 2018

NeuroImage: Clinical

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Mild cognitive impairment and Alzheimer's dementia involve a grey matter disease, quantifiable by 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET), but also white matter damage, evidenced by diffusion tensor magnetic resonance imaging (DTI), which may play an additional pathogenic role. This study aimed to determine whether such DTI and PET variations are also interrelated in a high-risk population of older hypertensive patients with only subjective memory complaints (SMC).Sixty older hypertensive patients (75 ± 5 years) with SMC were referred to DTI and FDG-PET brain imaging, executive and memory tests, as well as peripheral and central blood pressure (BP) measurements. Mean apparent diffusion coefficient (ADCmean) was determined in overall white matter and correlated with the grey matter distribution of the metabolic rate of glucose (CMRGlc) using whole-brain voxel-based analyses of FDG-PET images.ADCmean was variable between individuals, ranging from 0.82 to 1.01.10− 3 mm2 sec− 1, and mainly in relation with CMRGlc of areas involved in Alzheimer's disease such as internal temporal areas, posterior associative junctions, posterior cingulum but also insulo-opercular areas (global correlation coefficient: − 0.577, p < 0.001). Both the ADCmean and CMRGlc of the interrelated grey matter areas were additionally and concordantly linked to the results of executive and memory tests and to systolic central BP (all p < 0.05).Altogether, our findings show that cross-sectional variations in overall white brain matter are linked to the metabolism of Alzheimer-like cortical areas and to cognitive performance in older hypertensive patients with only subjective memory complaints. Additional relationships with central BP strengthen the hypothesis of a contributing pathogenic role of hypertension.

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Objective features of subjective cognitive decline in a United States national database

Cited by 55 publications

References 44 publications

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Beneficial impact of education on cognition in amyloid-positive individuals with subjective cognitive decline: The SILCODE study

Cross-sectional variations of white and grey matter in older hypertensive patients with subjective memory complaints

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