Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Zlatar, Zvinka Z.; Muniz, Martha; Espinoza, Sarah; Gratianne, Roberto; Gollan, Tamar H.; Galasko, Douglas; Salmon, David P.

doi:10.3233/jad-170865

Cited by 46 publications

(33 citation statements)

References 34 publications

(49 reference statements)

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“…A behavior study showed that enhanced transfer of the auditory discrimination learning is mediated by WM, which reflects that WM updating is related to fine auditory discrimination (Zhang et al, 2016 ). Actually, SCD is not strongly correlated with the concurrent level of cognitive ability as measured by objective cognitive tests; previous studies have shown that subjective memory complaints are associated with subsyndromal or subclinical depression in community-dwelling older adults (Zlatar et al, 2018 ). Therefore, the targeting of specific interventions for the regulation of cognitive ability will be more helpful in the case of the intervention treatment of patients with heterogeneous SCD.…”

Section: Discussionmentioning

confidence: 92%

Enhancing Working Memory Based on Mismatch Negativity Neurofeedback in Subjective Cognitive Decline Patients: A Preliminary Study

Pei

Yang

Shi

et al. 2020

Front. Aging Neurosci.

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Mismatch negativity (MMN) is suitable for studies of preattentive auditory discriminability and the auditory memory trace. Subjective cognitive decline (SCD) is an ideal target for early therapeutic intervention because SCD occurs at preclinical stages many years before the onset of Alzheimer’s disease (AD). According to a novel lifespan-based model of dementia risk, hearing loss is considered the greatest potentially modifiable risk factor of dementia among nine health and lifestyle factors, and hearing impairment is associated with cognitive decline. Therefore, we propose a neurofeedback training based on MMN, which is an objective index of auditory discriminability, to regulate sensory ability and memory as a non-pharmacological intervention (NPI) in SCD patients. Seventeen subjects meeting the standardized clinical evaluations for SCD received neurofeedback training. The auditory frequency discrimination test, the visual digital N-back (1-, 2-, and 3-back), auditory digital N-back (1-, 2-, and 3-back), and auditory tone N-back (1-, 2-, and 3-back) tasks were used pre- and post-training in all SCD patients. The intervention schedule comprised five 60-min training sessions over 2 weeks. The results indicate that the subjects who received neurofeedback training had successfully improved the amplitude of MMN at the parietal electrode (Pz). A slight decrease in the threshold of auditory frequency discrimination was observed after neurofeedback training. Notably, after neurofeedback training, the working memory (WM) performance was significantly enhanced in the auditory tone 3-back test. Moreover, improvements in the accuracy of all WM tests relative to the baseline were observed, although the changes were not significant. To the best of our knowledge, our preliminary study is the first to investigate the effects of MMN neurofeedback training on WM in SCD patients, and our results suggest that MMN neurofeedback may represent an effective treatment for intervention in SCD patients and the elderly with aging memory decline.

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Section: Discussionmentioning

confidence: 92%

Enhancing Working Memory Based on Mismatch Negativity Neurofeedback in Subjective Cognitive Decline Patients: A Preliminary Study

Pei

Yang

Shi

et al. 2020

Front. Aging Neurosci.

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“…As most SCD cases are benign, or not caused by degenerative brain disease [17], it has been suggested that SCD may be associated with depression, rather than preclinical AD [58,59]. While it has been reported that presentation of SCD may correlate with depression rather than objective cognitive decline [60,61], the link between SCD and depressive symptoms has not been universally supported [62,63].…”

Section: Discussionmentioning

confidence: 99%

Amyloid Plaques and Symptoms of Depression Links to Medical Help-Seeking due to Subjective Cognitive Decline

Espenes

Kirsebom

Eriksson

et al. 2020

JAD

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Background: Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer's disease (AD). However, patients reporting SCD to their general practitioner are not always referred to a memory clinic. Objective: To investigate whether prior history of medical help-seeking is associated with AD biomarker abnormality, worse cognitive performance, and/or depressive symptoms in SCD. Methods: We compared levels of cerebrospinal fluid (CSF) A␤ 1-42 , cognitive performance, and depressive symptoms (15item Geriatric Depression Scale, GDS-15) between healthy controls (n = 88), SCD with a history of medical help seeking (SCD-HS, n = 67), and SCD non help-seekers (SCD-NHS, n = 44). Cases with evidence of amyloid plaques (CSF A␤ 1-42 ≤708 ng/l) and symptoms of depression (GDS-15≥6) were determined in both SCD groups. Results: The SCD-HS group had lower CSF A␤ 1-42 (p < 0.01), lower word list learning and memory recall (p < 0.0001), and an increased level of depressive symptoms (p < 0.0001) compared to controls and SCD-NHS cases. The SCD-HS group had more cases with symptoms of depression (n = 12, 18%) and amyloid plaques (n = 18, 27%) compared to SCD-NHS (n = 1, 2% and n = 7, 16%, respectively). None of the SCD-HS cases and only one SCD-NHS case had concurrent symptoms of depression and amyloid plaques. The SCD-HS cases showed equal word list learning and memory performance regardless of amyloid status or symptoms of depression. Conclusion: Medical help-seeking in SCD is associated with an increased risk of AD pathology or symptoms of depression. However, subtle memory deficits are seen in SCD help-seekers, also without amyloid plaques or symptoms of depression.

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“…Depression was significantly related with subjective memory complaints among people with migraines . Moreover, subjective memory complaints were closely associated with self‐reported depressive symptoms rather than with objective cognitive performance, and this is consistent with our finding. Depressive status increases subjective memory complaints consistently across groups with different cognitive statuses .…”

Section: Discussionmentioning

confidence: 99%

Subjective cognitive complaints and migraine characteristics: A cross‐sectional study

et al. 2020

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Objectives Subjective cognitive complaints by patients with migraine have been associated with memory impairment. However, whether the severity of memory impairment relates to migraine characteristics, such as attack frequency and aura, remains undetermined. We investigated the relationship between subjective cognitive complaints and migraine characteristics. Materials and methods This cross‐sectional study recruited 669 clinic outpatients from Taiwan. We stratified them by migraine frequency and the presence or absence of aura, and we controlled the data for confounding variables. We performed multivariable linear and logistic regressions to investigate whether different migraine frequencies are associated with subjective cognitive complaints, which were evaluated by the subjective memory complaints scale and the Ascertain Dementia 8 (AD8) questionnaire. Results Total subjective memory complaints scores tended to increase with the migraine attack frequency (P = .022) in patients with migraine with aura; similar results were obtained for AD8 scores in women with migraine with aura. Poor sleep quality was associated with a higher total subjective memory complaint (B = 0.08, 95% confidence interval [CI] = 0.03‐0.14) and AD8 (B = 0.07, 95% CI = 0.02‐0.11) scores. In addition, more severe depression was associated with higher total subjective memory complaints and AD8 scores (B = 0.05, 95% CI = 0.02‐0.09; B = 0.08, 95% CI = 0.05‐0.11, respectively). Conclusions Subjective cognitive complaints tend to increase with the frequency of migraines with aura, and this interrelation is substantially influenced by depression severity and sleep disturbances.

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Subjective Cognitive Decline, Objective Cognition, and Depression in Older Hispanics Screened for Memory Impairment

Cited by 46 publications

References 34 publications

Enhancing Working Memory Based on Mismatch Negativity Neurofeedback in Subjective Cognitive Decline Patients: A Preliminary Study

Enhancing Working Memory Based on Mismatch Negativity Neurofeedback in Subjective Cognitive Decline Patients: A Preliminary Study

Amyloid Plaques and Symptoms of Depression Links to Medical Help-Seeking due to Subjective Cognitive Decline

Subjective cognitive complaints and migraine characteristics: A cross‐sectional study

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