Objective, computerized video-based rating of blepharospasm severity

Peterson, David A.; Littlewort, Gwen; Bartlett, Marian Stewart; Macerollo, Antonella; Perlmutter, Joel S.; Jinnah, Hyder A.; Hallett, Mark; Sejnowski, Terrence J.

doi:10.1212/wnl.0000000000003336

Cited by 23 publications

(19 citation statements)

References 25 publications

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“…This software provides an objective assessment of the amount of evidence for different emotions in facial expressions. (For use of this software in other research, see Bartlett, Littlewort, Frank, & Lee, 2014;Gordon, Pierce, Bartlett, & Tanaka, 2014;Peterson et al, 2016;Sikka et al, 2015;Zanette, Gao, Brunet, Bartlett, & Lee, 2016).…”

Section: Methodsmentioning

confidence: 99%

Sensorimotor simulation and emotion processing: Impairing facial action increases semantic retrieval demands

Davis

Winkielman

Coulson

2017

Cogn Affect Behav Neurosci

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Sensorimotor models suggest that understanding the emotional content of a face recruits a simulation process in which a viewer partially reproduces the facial expression in their own sensorimotor system. An important prediction of these models is that disrupting simulation should make emotion recognition more difficult. Here we used electroencephalogram (EEG) and facial electromyogram (EMG) to investigate how interfering with sensorimotor signals from the face influences the real-time processing of emotional faces. EEG and EMG were recorded as healthy adults viewed emotional faces and rated their valence. During control blocks, participants held a conjoined pair of chopsticks loosely between their lips. During interference blocks, participants held the chopsticks horizontally between their teeth and lips to generate motor noise on the lower part of the face. This noise was confirmed by EMG at the zygomaticus. Analysis of EEG indicated that faces expressing happiness or disgust-lower face expressions-elicited larger amplitude N400 when they were presented during the interference than the control blocks, suggesting interference led to greater semantic retrieval demands. The selective impact of facial motor interference on the brain response to lower face expressions supports sensorimotor models of emotion understanding.

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Section: Methodsmentioning

confidence: 99%

Sensorimotor simulation and emotion processing: Impairing facial action increases semantic retrieval demands

Davis

Winkielman

Coulson

2017

Cogn Affect Behav Neurosci

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“…In pilot studies, this strategy was used to quantify blinks and spasms among subjects with blepharospasm (47). The results demonstrated good correlations with clinical rating scales.…”

Section: Objective Measures Projectmentioning

confidence: 99%

The Dystonia Coalition: A Multicenter Network for Clinical and Translational Studies

et al. 2021

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Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions causing abnormal postures, repetitive movements, or both. Research in dystonia has been challenged by several factors. First, dystonia is uncommon. Dystonia is not a single disorder but a family of heterogenous disorders with varied clinical manifestations and different causes. The different subtypes may be seen by providers in different clinical specialties including neurology, ophthalmology, otolaryngology, and others. These issues have made it difficult for any single center to recruit large numbers of subjects with specific types of dystonia for research studies in a timely manner. The Dystonia Coalition is a consortium of investigators that was established to address these challenges. Since 2009, the Dystonia Coalition has encouraged collaboration by engaging 56 sites across North America, Europe, Asia, and Australia. Its emphasis on collaboration has facilitated establishment of international consensus for the definition and classification of all dystonias, diagnostic criteria for specific subtypes of dystonia, standardized evaluation strategies, development of clinimetrically sound measurement tools, and large multicenter studies that document the phenotypic heterogeneity and evolution of specific types of dystonia.

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“…In addition, TD researchers and clinicians may need to start thinking about optimal ways to adopt new technologies, such as wearable sensors, computerized video-based ratings, and smartphone-based monitoring of abnormal movements and other symptoms. [48][49][50][51] The Working Group also agreed that more research is needed to better understand the relationship between the AIMS and other assessment tools, including patient-reported measures, caregiver/informant measures, functional scales, and quality of life questionnaires. Future research should also include the use of a broader array of descriptive statistics from the AIMS in epidemiologic studies of TD, particularly in at-risk populations (eg, elderly, women) and in different populations of patients requiring antipsychotic treatment (eg, schizophrenia, schizoaffective disorder, bipolar disorder, refractory major depressive disorder).…”

Section: Summary and Future Directionsmentioning

confidence: 99%

Revisiting the Abnormal Involuntary Movement Scale

Kane

Correll

Nierenberg

et al. 2018

J. Clin. Psychiatry

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Objective: To provide an historic overview of the Abnormal Involuntary Movement Scale (AIMS) in clinical trials of tardive dyskinesia (TD), with current recommendations for analyzing and interpreting AIMS data. Participants: Seven psychiatrists and 1 neurologist were selected by the workshop sponsor based on each individual's clinical expertise and research experience. Evidence: Using PubMed entries from January 1970 to August 2017, participants selected studies that used the AIMS to evaluate TD treatments. The selections were intended to be representative rather than prescriptive or exhaustive, and no specific recommendations for TD treatment are implied. Consensus Process: The Working Group met in October 2016 to discuss the AIMS as an assessment tool, outline the challenges of translating clinical trial results into everyday clinical practice, and propose different methods for reporting AIMS data in clinically relevant terms. Recommendations for selecting TD studies for review, analyzing and interpreting AIMS data, and synthesizing discussions among the participants were initiated during the onsite workshop and continued remotely throughout development of this report. Disagreements were resolved via group e-mails and teleconferences. Consensus was based on final approval of this report by all workshop participants. Conclusions: For both research and clinical practice, the AIMS is a valid measure for assessing TD and the effects of treatment, but alternative analyses of AIMS data (eg, effect size, minimal clinically important difference, response analyses, category shifts) may provide broader evidence of clinical effectiveness. No single analysis of AIMS data can be considered the standard of clinical efficacy; multiple analytic approaches are recommended. J Clin Psychiatry 2018;79(3) T ardive dyskinesia (TD) is a chronic disorder characterized by involuntary stereotyped, choreic, athetoid, and/or dystonic movements in 1 or more areas of the body, including the orofacial region (eg, tongue thrusting, lip smacking and/or pursing, grimacing), extremities (eg, stereotypic piano-playing movements, flexion/extension of the ankles or toes), and torso (eg, choreoathetoid movements, pelvic rocking).:1,2 This disorder can result from exposure to dopamine receptor blocking agents (DRBAs) such as antipsychotics and drugs used to treat gastrointestinal disorders (eg, metoclopramide). 2 Given the difficulty in treating TD, prevention, close monitoring, and earliest possible diagnosis are critical in optimizing patient outcomes.The term tardive dyskinesia was coined in 1964 by Faurbye et al 3 in an article that described patients who had developed chronic involuntary movements several months after starting antipsychotic treatment. In the following decades, the link between antipsychotics and TD became widely accepted, with attempts to find effective treatments for TD beginning in the early 1970s. 4 With development of the newer secondgeneration (atypical) antipsychotics, it was hoped that the risk for medication-in...

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Objective, computerized video-based rating of blepharospasm severity

Cited by 23 publications

References 25 publications

Sensorimotor simulation and emotion processing: Impairing facial action increases semantic retrieval demands

Sensorimotor simulation and emotion processing: Impairing facial action increases semantic retrieval demands

The Dystonia Coalition: A Multicenter Network for Clinical and Translational Studies

Revisiting the Abnormal Involuntary Movement Scale

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