Objective and Subjective Measurements of Cutaneous Inflammation after a Novel Hyaluronic Acid Injection

Judodihardjo, Harryono; Dykes, P.J.

doi:10.1111/j.1524-4725.2008.34252.x

Cited by 9 publications

(7 citation statements)

References 9 publications

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“…29 However, filler agents can occasionally elicit a more severe chronic inflammatory response within the subcuta- neous tissues that can present with swelling. This complication is mainly encountered with long-term and permanent fillers, such as silicone, and is predisposed by underlying inflammatory diseases, such allergies, as well as regional infectious processes, such as dental caries and sinusitis.…”

Section: Complicationsmentioning

confidence: 99%

Imaging Features of Midface Injectable Fillers and Associated Complications

Ginat

Schatz

2012

AJNR Am J Neuroradiol

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Section: Complicationsmentioning

confidence: 99%

Imaging Features of Midface Injectable Fillers and Associated Complications

Ginat

Schatz

2012

AJNR Am J Neuroradiol

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“…17,18 Since the chemical structure of animal or nonanimal-derived HA is identical to that in humans, it should be the ideal biomaterial provoking no reaction. 4,5,19 However, short term acute but transient inflammatory reactions are common, 20,21 while rare longterm adverse events may correlate with subclinical chronic inflammation. 6,22 The cause of observed inflammatory reactions has been a matter of debate.…”

Section: Introductionmentioning

confidence: 99%

“…Possibilities range from the unavoidable trauma of tissue during injection or from poor implantation surgical technique to contamination from impurities such as bacterial endotoxin and foreign proteins or DNA. 20,21,23 As endotoxin contamination and protein content have been reduced, inflammatory reactions in patients have decreased in incidence but have not been eliminated. 4,5 Concern has focused on low molecular weight (LMW) components or degradation fragments from implanted HA-containing devices to account for observed inflammatory reactions.…”

Section: Introductionmentioning

confidence: 99%

Low molecular weight hyaluronic acid effects on murine macrophage nitric oxide production

Lyle

Breger

Baeva

et al. 2010

J Biomedical Materials Res

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Hyaluronic acid (HA) is increasingly used for a number of medical device applications. Since the chemical structure of HA is identical no matter its bacterial or animal origin, it should be the ideal biomaterial. However, short term transient inflammatory reactions are common, while rare long-term adverse events may correlate with subclinical chronic inflammation. Concern has been raised that low molecular weight components or degradation fragments from implanted HA may directly stimulate inflammatory reactions. This study examined a panel of HA molecular weights from the unitary disaccharide up to 1.7 x 10(6) Dalton lengths, in which endotoxin was assayed at a very low level (less than 0.03 EU/mg). The murine cell line RAW 264.7, rat splenocytes, and rat adherent differentiated primary macrophages were assayed for nitric oxide production under a variety of inflammatory conditions plus or minus HA. Under the highest inflammatory states, nitric oxide production was mildly suppressed by HMW-HA while slightly augmented by LMW-HA at mg/mL concentrations. However, at micromolar concentrations fragments below 5000 Daltons, thought to have drug-like qualities, were without effect. These data support the hypothesis that if endotoxin is reduced to an extremely low level, LMW-HA may not directly provoke normal tissue macrophage-mediated inflammatory reactions.

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“…Hyaluronic acid is most commonly used, but other agents include collagen, silicone, and polytetrafluoroethylene. The CT and MRI appearance of these agents vary, but a transient inflammatory reaction is common, with occasional occurrences of a severe chronic inflammatory response with diffuse swelling and enhancement of the orofacial soft tissues ( 13 , 14 ). Knowledge of the appropriate clinical history is necessary to avoid this potential pitfall.…”

Section: Discussionmentioning

confidence: 99%

Invasive facial fungal infections: Orofacial soft-tissue infiltration in immunocompromised patients

Jun¹,

Russell²,

El‐Sayed³

et al. 2013

Radiology Case Reports

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Invasive facial fungal infections affect the orofacial soft tissues in immunocompromised patients and can cause significant morbidity and mortality. Primary infection occurs from direct inoculation of the skin surface, while secondary infection occurs from extension from an adjacent sinonasal process. The imaging features of secondary infection are similar to acute fulminant invasive fungal sinusitis with infiltration of the orofacial soft tissues in combination with sinonasal disease. However, primary infection can occur in the absence of sinonasal disease, making diagnosis challenging. We present two cases, one of primary and one of secondary invasive facial fungal infection. Careful scrutiny of the orofacial soft tissues in immunocompromised patients is necessary to detect invasive facial fungal infections so that appropriate surgical and medical therapies can maximize patient outcomes.

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Objective and Subjective Measurements of Cutaneous Inflammation after a Novel Hyaluronic Acid Injection

Abstract: The results of this study show that the erythema meter and the infrared thermometer are effective tools to objectively measure mild inflammation post-HA injection.

Cited by 9 publications

References 9 publications

Imaging Features of Midface Injectable Fillers and Associated Complications

Imaging Features of Midface Injectable Fillers and Associated Complications

Low molecular weight hyaluronic acid effects on murine macrophage nitric oxide production

Invasive facial fungal infections: Orofacial soft-tissue infiltration in immunocompromised patients

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