Obesity, weight loss, and the polycystic ovary syndrome: effect of treatment with diet and orlistat for 24 weeks on insulin resistance and androgen levels

Panidis, Dimitrios; Farmakiotis, Dimitrios; Rousso, David; Kourtis, Anargyros; Katsikis, Ilias; Krassas, G.E.

doi:10.1016/j.fertnstert.2007.04.043

Cited by 103 publications

(69 citation statements)

References 48 publications

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“…Lim et al [20], reported their disagreement with such hypothesis concerning the association between the lack of exercise and the clinical or biochemical characteristics typical of PCOS, supporting the concept of weight reduction in favor of exercise in the field of lifestyle modification. Many studies support our results concerning the positive effects of weight reduction on obese PCOS women [18][19][21][22], which is further supported by studying the eating habits of PCOS women compared to controls; Adult PCOS women tend to eat between meals and adolescents PCOS tend to have non healthy snacks which may intensify the phenotype of PCOS. Adolescents also tend to eat out of pleasure rather than out of necessity, which may lead to a progressively increasing caloric intake and a tendency to bulimic eating pattern, which is a common behavior shown among women with PCOS (12,23).…”

Section: Discussionsupporting

confidence: 83%

Effect of Diet Control Therapy on the Dermatological Symptoms of Obese Polycystic Ovarian Syndrome Women: Repeated Measure Design

Mahmoud¹

2018

IJPR

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Background: Polycystic ovarian syndrome (PCOS) is the most common endocrinal disorder in female causing metabolic, cutaneous, and reproductive disorders.Purpose: This repeated measure study was designed to investigate the effect of diet control therapy on hyperandrogen symptoms (Acne & Hirsutism) in obese PCOS women.Subjects and Methods: Thirty PCOS obese women were recruited, their age ranged from 20 to 30 years and their BMI ranged from 30 to 34.9 kg/m 2 . All of them received diet control therapy, and were evaluated before, after 12 weeks and after 24 weeks of therapy through measuring their weight, C-reactive protein, luteinizing hormone (LH) / follicular stimulating hormone (FSH) ratio, androgen excess symptoms (modified Ferryman-Gallwey (mFG) scoring system & global acne grading system (GAGS).Results: Repeated Measure MANOVA showed a statistically significant difference (P < 0.05) between the pretreatment compared to after therapy (in both 12 and 24 weeks) in LH/FSH ratio, CRP, mFG and GAGS, however no significance difference was found between 12 weeks and 24 weeks for all the dependent variables. As well as, Pearson's product-moment correlation revealed a weak positive correlation between C-reactive protein and androgen excess symptoms (Acne & Hirsutism). Conclusion:Three months following the recommended diet control therapy is an effective therapy for improving the cutaneous symptoms and fertility through the hormonal variables of PCOS patients. Diet control therapy for another consequent three months is also recommended to keeping this improvement.

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Section: Discussionsupporting

confidence: 83%

Effect of Diet Control Therapy on the Dermatological Symptoms of Obese Polycystic Ovarian Syndrome Women: Repeated Measure Design

Mahmoud¹

2018

IJPR

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“…Data from the recent studies on the use of sibutramine in obese patients with PCOS clearly show that treatment with this drug for 6 months together with lifestyle intervention, results in weight reduction and may also decrease hyperandrogenaemia and IR (Sabuncu et al, 2003;Florakis et al, 2008;Lindholm et al, 2008). Treatment with orlistat, a potent inhibitor of gastric and pancreatic carboxyl-ester lipase which impairs digestion of dietary fats, combined with hypo-caloric diet apart from decreasing body weight also led to a reduction of serum insulin and androgen levels in obese PCOS patients (Jayagopal et al, 2005;Diamanti-Kandarakis et al, 2007a;Panidis et al, 2008).…”

Section: Pharmacological Management Of Obesity In Pcos Patientsmentioning

confidence: 99%

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Rachoń

Teede

2010

Molecular and Cellular Endocrinology

128

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Insulin resistance (IR) is a consequence of obesity, and in women it is often inextricably linked with ovarian function leading to clinical reproductive manifestations such as early menarche onset, subfertility and polycystic ovary syndrome (PCOS). Likewise, the dramatic fall in oestrogen production after menopause may contribute to weight gain and changes in adipose tissue distribution.Overall, women who are obese, especially those with reproductive complications including PCOS, have been identified as specific high risk subgroups for further progression through to prediabetes, type 2 diabetes mellitus (T2DM) and potentially cardiovascular disease (CVD). This review focuses on the interrelationship between the ovarian function and obesity as well as its treatment strategies.

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“…Panidis et al reported that orlistat in combination with diet produced significant weight loss and improvement in insulin sensitivity in obese women, with or without PCOS. In addition, serum testosterone levels were significantly improved in women with PCOS (Panidis et al, 2008). Based on these data pilot studies of orlistat in NCAH should be performed.…”

Section: Orlistat Pilot Studiesmentioning

confidence: 91%

Management Approaches to Congenital Adrenal Hyperplasia in Adolescents and Adults; Latest Therapeutic Developments

Bahtiyar¹,

Sacerdote²

2011

Amenorrhea

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Obesity, weight loss, and the polycystic ovary syndrome: effect of treatment with diet and orlistat for 24 weeks on insulin resistance and androgen levels

Cited by 103 publications

References 48 publications

Effect of Diet Control Therapy on the Dermatological Symptoms of Obese Polycystic Ovarian Syndrome Women: Repeated Measure Design

Effect of Diet Control Therapy on the Dermatological Symptoms of Obese Polycystic Ovarian Syndrome Women: Repeated Measure Design

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Management Approaches to Congenital Adrenal Hyperplasia in Adolescents and Adults; Latest Therapeutic Developments

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