Obesity Severity and Duration Are Associated With Incident Metabolic Syndrome: Evidence Against Metabolically Healthy Obesity From the Multi-Ethnic Study of Atherosclerosis

Mongraw‐Chaffin, Morgana; Foster, Meredith C.; Kalyani, Rita R.; Vaidya, Dhananjay; Burke, Gregory L.; Woodward, Mark; Anderson, Cheryl A.M.

doi:10.1210/jc.2016-2460

Cited by 94 publications

(86 citation statements)

References 28 publications

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“…It has been reported that central obesity is one of the main characteristics of MetS, particularly due to increased values of free fatty acids in the blood and the inhibition of insulin action in peripheral tissues [50,51,52]. In the present study, we observed 10.7% of central obesity in the population assessed, a value that increased to 56.6% in individuals with MetS.…”

Section: Discussionsupporting

confidence: 61%

A Cross-Sectional Study of the Prevalence of Metabolic Syndrome and Associated Factors in Colombian Collegiate Students: The FUPRECOL-Adults Study

Martínez-Torres

Correa-Bautista

González-Ruíz

et al. 2017

IJERPH

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Metabolic syndrome (MetS) is one of the major public health problems worldwide. The objective of the present study is to investigate the prevalence and the associated variables of MetS in Colombian collegiate students. This cross-sectional study included a total of 890 (52% women) healthy collegiate students (21.3 ± 3.2 years old). The prevalence of MetS was determined by the definition provided by the International Diabetes Federation (IDF). We further examined associations between the prevalence of MetS and related factors, such as age, gender, anthropometric and body composition, weight status, and nutrition profile. The overall prevalence of MetS was 6.0% (95% CI = 4.5% to 7.6%), and it was higher in men than women. The most prevalent components were low high-density lipoprotein cholesterol, high triglyceride levels, waist circumference, and blood pressure levels. The predisposing factors for having a MetS included: being male, over 23 years old, overweight or obese, and having an unhealthy waist-to-height ratio. In conclusion, the occurrence of MetS in young adults is substantial. These findings may be relevant to health promotion efforts for collegiate students in order to develop prospective studies and screening for young adults, which will aid in targeted intervention development to decrease cardiometabolic risk factors.

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Section: Discussionsupporting

confidence: 61%

A Cross-Sectional Study of the Prevalence of Metabolic Syndrome and Associated Factors in Colombian Collegiate Students: The FUPRECOL-Adults Study

Martínez-Torres

Correa-Bautista

González-Ruíz

et al. 2017

IJERPH

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“…Thus, early detection of abnormality in circulating levels of apoptotic EPCs may be a biomarker of IR and predictor of Met-UHO in patients with abdominal obesity when other metabolic disturbances are absent or evidence regarding them is fare limited. Recently it has been suggested that Met-HO is a stage of development of Met-UHO and T2DM (Mongraw-Chaffin et al, 2016). However, our results revealed that the most important factor that affects metabolic dysregulation in obesity is IR, which probably appears to be predominantly early stage of the Met-HO.…”

Section: Discussioncontrasting

confidence: 52%

“…Moreover, it is suggesting that Met-HO is a transient state in the pathway to cardiometabolic disease, i.e. Met-UHO and T2DM (Mongraw-Chaffin et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Circulating apoptotic endothelial cell-derived microparticles are predicted metabolically unhealthy obesity

Berezin

Kremzer

Berezina³

et al. 2017

Biomed Res Ther

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Introduction: Circulating apoptotic endothelial cell-derived micro particles (EMPs) are a marker of endothelial dysfunction and cardiovascular (CV) risk in type 2 diabetes mellitus patients. There is evidence regarding association between apoptotic EMP number and CV disease in obese individuals. The aim of the study to investigate whether increased number of circulating apoptotic EMPs may predict transformation of Met-HO into Met-UHO. Methods: The study was retrospectively evolved 89 patients with established abdominal obesity (47 patients with Met-UHO determined as MetS and 42 subjects with Met-HO) from the large cohort of abdominal obesity patients (n=268). Thirty five healthy volunteers matched for age and sex were involved in the study as a control cohort. Obesity-related biomarker (adiponectin, leptin, vistafin) and EMPs were measured at baseline. Flow cytometry was used to determine EMPs with immune phenotype CD31+/ annexin V+ and CD144+/annexin V+. Results: There was not found a significant difference between numbers of EMPs labeled CD31 + / Annexin V + in Met-UHO and Met-HO patients, while Met-UHO patients had a significantly increased level of circulating CD144 + / Annexin V + compared with Met-HO individuals. Multivariate logistic regression analysis has revealed the HOMA-IR, number of CV risk factors, serum leptin and hs-CRP independently predicted numbers of circulating CD31 + / Annexin V + and CD144 + / Annexin V + EMPs in Met-UHO. In Met-HO patients HOMA-IR remained an independent predictor of increased numbers of circulating CD31 + / Annexin V + and CD144 + / Annexin V + EMPs. Conclusion: in the investigation we found that the increased number of CD31 + /Annexin V + and CD144 + / Annexin V + EMPs added to the based predictive model (HOMA-IR) may predict transformation of Met-HO into Met-UHO.

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“…Moreover, younger patients are less likely to have cardioembolic strokes and atrial fibrillation which have been shown to be associated with more severe strokes, large infarct volumes, and higher rates of hemorrhagic transformation and, therefore, carry a worse prognosis. Additionally, a recent analysis showed that both the severity and duration of obesity are important in the development of metabolic syndrome, meaning that “healthy” obesity is only a transitional state [16]. Our patients might have been in that transitional healthy state and developed a stroke as their first cardiovascular event, and, thus, a longer observation period beyond 90 days might help better assess outcomes in this population.…”

Section: Discussionmentioning

confidence: 97%

Body Mass Index and Clinical Outcomes in Large Vessel Occlusion Acute Ischemic Stroke after Endovascular Therapy

et al. 2019

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Background and Purpose: Several reports have described lower mortality rates in overweight or obese patients as compared to normal weight ones. In the past decade, several studies have investigated the phenomenon, commonly known as the obesity paradox, with mixed results thus far. We sought to determine whether outcomes differ between patients with large vessel occlusion strokes (LVOS) after endovascular therapy (ET) according to their body mass index (BMI). Methods: We reviewed our prospectively collected endovascular database at a tertiary care academic institution. All patients that underwent ET for acute LVOS were categorized according to their BMI into 4 groups: (1) underweight (BMI < 18.5), (2) normal weight (BMI = 18.5–25), (3) overweight (BMI = 25–30), and (4) obese (BMI > 30). Baseline characteristics, procedural radiological as well as outcome parameters where compared. Results: A total of 926 patients qualified for the study, of which 20 (2.2%) were underweight, 253 (27.3%) had a normal weight, 315 (34%) were overweight, and 338 (36.5%) were obese. When compared with normal weight (reference), overweight patients were younger, had higher rates of dyslipidemia and diabetes and higher glucose levels, while obese patients were younger, less often smokers, and had higher rates of hypertension and diabetes and higher glucose levels. Other baseline and procedural characteristics were comparable. The rates of successful reperfusion (modified treatment in cerebral ischemia, 2b–3), parenchymal hematomas, 90-day good clinical outcomes (modified Rankin scale, 0–2), and 90-day mortality were comparable between groups. On multivariate analysis, BMI was not associated with good outcomes nor mortality. Conclusion: In patients treated with mechanical thrombectomy, BMI is not associated with outcomes. However, patients who are overweight or obese have more comorbidities and a higher stroke risk and, thus, should strive for a normal weight.

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Obesity Severity and Duration Are Associated With Incident Metabolic Syndrome: Evidence Against Metabolically Healthy Obesity From the Multi-Ethnic Study of Atherosclerosis

Cited by 94 publications

References 28 publications

A Cross-Sectional Study of the Prevalence of Metabolic Syndrome and Associated Factors in Colombian Collegiate Students: The FUPRECOL-Adults Study

A Cross-Sectional Study of the Prevalence of Metabolic Syndrome and Associated Factors in Colombian Collegiate Students: The FUPRECOL-Adults Study

Circulating apoptotic endothelial cell-derived microparticles are predicted metabolically unhealthy obesity

Body Mass Index and Clinical Outcomes in Large Vessel Occlusion Acute Ischemic Stroke after Endovascular Therapy

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