Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors

Bellver, José; Pellicer, António; García-Velasco, Juan A.; Ballesteros, A.; Remohı́, José; Meseguer, Marcos

doi:10.1016/j.fertnstert.2013.06.001

Cited by 193 publications

(123 citation statements)

References 45 publications

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“…22 A recent data analyzing more than 9500 first cycles of ovum donation with ova from normal weight donors revealed that implantation and live birth rates were significantly reduced with increasing BMI. 23 Even if some authors suggest that the probable cause of unfavorable outcomes was linked with reduced uterine receptivity in obesity, we failed to reach such a conclusion as peak echo measurements and implantation rates were all comparable among BMI groups.…”

Section: Discussionmentioning

confidence: 80%

The Impact of Body Mass Index on ART Outcomes of High-Responders: Prospective Cohort Study

Pabuçcu¹,

Çağlar²,

Kiseli³

et al. 2017

TJRMS

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A AB BS S T TR RA AC CT TO Ob bj je ec ct ti iv ve e: : Is to evaluate the impact of body mass index (BMI) levels on pregnancy outcomes in high-responders undergoing assisted reproductive technology (ART). M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Total of 120 high responders was allocated to the study. High response was defined as having high serum AMH levels (>4 ng/ml). Subjects were divided into three groups according to their BMI values; normal weight 57 (BMI 18.5-24.9 kg/m 2 ), overweight 42 (25-29.9 kg/m 2 ) and obese 21 subjects (BMI ≥30 kg/m 2 ) were compared for pregnancy outcomes and Ovarian Hyperstimulation Syndrome (OHSS) rates. Gonadotropin starting dose was fixed to 150 IU/day in antagonist co-treated cycles for all subjects. R Re es su ul lt ts s: : A total of 120 cycles were evaluated. In patients with BMI ≥30 kg/m 2 , the total gonadotropin use was significantly higher (p<0.001) and number of retrieved oocytes was significantly lower (p=0.001) when compared to other groups. In normal weight patients, significantly higher numbers of mature oocytes and 2PN embryos were obtained when compared with other groups (p<0.001). Other parameters including number of good quality embryos available for transfer, implantation, biochemical, clinical pregnancy and OHSS rates were similar between all groups. C Co on nc cl lu us si io on n: : Our results did not reveal a significant effect of BMI on the ART outcomes of high responder infertile women. Although higher BMI was correlated with less number of retrieved oocytes, it did not resulted with a negative impact on pregnancy outcomes. Another interesting finding was the trend to a less OHSS incidence with the increase in BMI of high responder patients.K Ke ey y W Wo or rd ds s: : AMH, BMI, high responder, OHSS, pregnancy Ö ÖZ ZE ET T A Am ma aç ç: : Yardımla üreme teknikleri (YÜT) uygulanan yüksek ovaryen yanıtlı olgularda, farklı beden kitle indeksinin (BKİ), gebelik sonuç-ları üzerine etkisini incelemek. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Farklı BKİ değerlerine sahip toplam 120 yüksek ovaryen yanıtlı olgu çalışmaya dahil edildi. Yüksek yanıt kriteri olarak olgudaki serum AMH değerinin >4 ng/ml olması kabul edildi. BKİ değerlerine göre olgular 3 gruba ayrıldı: normal kilolu 57 olgu (BKİ 18,5-24,9 kg/m 2 ), fazla kilolu 42 olgu (BKİ 25-29,9 kg/m 2 ), obez 21 olgu (BKİ >30 kg/m 2 ), gebelik ve ovaryen hiperstimulasyon sendromu (OHSS) oranları açısından karşılaştırıldı. B Bu ul lg gu ul la ar r: : Obez grupta, hem kullanılan gonadotropin dozu hem de toplanan oosit sayısı, diğer 2 gruba göre anlamlı olarak daha az saptandı (p<0,05). Fertilizasyon, gebelik oranları ve diğer parametreler açısından gruplar arasında farklılık saptanmadı. S So on nu uç ç: : YÜT uygulaması yapılan yüksek yanıtlı olgularda, BKİ değerlerinin, YÜT sonuçlarına belirgin etkisinin olmadığı ortaya konulmuştur. Obez olgularda toplanan oosit sayısının az olmasının yanında, gebelik oranlarında farklılık saptanmamıştır. OHSS oranlarının, BKİ arttıkça bir miktar...

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Section: Discussionmentioning

confidence: 80%

The Impact of Body Mass Index on ART Outcomes of High-Responders: Prospective Cohort Study

Pabuçcu¹,

Çağlar²,

Kiseli³

et al. 2017

TJRMS

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“…There are studies which stated that endometrial receptivity and reproductive outcome are broken as BMI increases. [15][16][17] The fact that the correlation between BMI and β-hCG is broken in the triplet pregnancies in this studies may be caused by the insufficient number of the patients in that group.…”

Section: Discussionmentioning

confidence: 86%

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Kalem¹,

Kalem²,

Gürgan³

2017

TJRMS

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-hCG (beta-human chorionic gonadotrophin) is a pregnancy-associated molecule produced by implanted blastocysts and trophoblastic cells. β-hCG as one of the earliest embryonal signals may be a major regulator in the paracrine embryo-endometrial communication.1,2 β-hCG measurement in serum is a method used routinely for pregnancy test after the IVF (invitro fertilization) procedure.3 Serial measurements of β-hCG is a marker which is also used for distinguishing pregnancies running their course from ectopic pregnancy or spontaneous pregnancy losses in early pregnancy. [4][5][6] In increasing number of recent studies, it has become a current issue that β-hCG levels in early A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The purpose of this study is to investigate the parameters of female, male and cycles that could affect post-ART (assisted reproductive techniques)-pregnancy initial beta hCG value. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this retrospective study, data of 3056 individuals who had become pregnant with IVF/ICSI at a private IVF center and between 2006 and 2016 and whose pregnancies continued for over 12 weeks were evaluated. Initial beta-hCG values of these pregnancies were compared with parameters of mothers, fathers and cycles. R Re es su ul lt ts s: : It was seen in this study that there is a negative correlation between the initial beta-hCG values of pregnancies achieved by assisted reproductive techniques and mothers BMI values and a positive correlation between those beta-hCG values and the embryo transfer day. C Co on nc cl lu us si io on n: : The data obtained in the study need to be supported with larger series in the future. It is also thought that these data may contribute to the literature which tries to achieve a β -hCG cut-off value in the determination of pregnancy outcome. Ya zış ma Ad re si/Cor res pon den ce:

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“…While environmental differences are hypothesized to underlie the observed associations between clinic location and donor egg IVF success, a number of unquantified variables could very well explain the observed directionality of association. Regional practice differences in IVF protocols, such as choice of ovarian suppression strategy, gonadotropin type and dose, and peak estradiol levels prior to ET [49], donor characteristics such as age and sibling donor [50], as well as regional differences in donor egg recipient profiles such as obesity [51], uterine factor [52,53], presence of hydrosalpinges [54] and even vitamin D deficiency [55] could underlie the observed phenomenon. The publically accessible data reported by SART include cumulative annual data for the reporting clinics; details on individual egg donors and recipients are lacking; similarly, in the absence of information on timing of the undertaken ART cycle/s, any inference regarding site specific UVB values during the time of ART cycle, or effect of seasonality cannot be attained.…”

Section: Discussionmentioning

confidence: 99%

Donor egg IVF model to assess ecological implications for ART success

Pal

Kidwai

Kayani

et al. 2014

J Assist Reprod Genet

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Purpose Environmental influences on reproductive success are recognized. We hypothesized that location of fertility clinics may influence treatment success and explored this hypothesis utilizing donor egg IVF (IVF) embryo transfer (ET) model. Methods Publicly accessible national registry data (Society for Assisted Reproductive Technology) on fresh & frozen (FET) ET cycles undertaken at participating clinics across North America (n=444 IVF centers) for 2007 were utilized. Information on number of donor egg IVF cycles, live birth (LB) rate following fresh and frozen ET(FET), average number (#) of ET and IVF center's location, geographical coordinates (latitude, longitude, altitude), annualized average temperatures and midyear regional ultraviolet B (UVB) radiation intensity were obtained. Multivariable logistic regression analyses assessed relationship between LBR (in tertile and uppermost versus lesser quartiles) following fresh and FET with geographical coordinates (region and altitude of clinic location) and ecological influences (average temperature and midyear UVB intensity), adjusting for #ET and clinic experience with donor egg IVF. Results Average number of fresh ET, clinic location (region) and midyear UVB intensity were positive predictors of LBR following fresh ET, whereas altitude and annualized average regional temperature demonstrated an inverse relationship with LBR following fresh ET. For FET cycles, #ET, clinic region and altitude were positive determinants of increasing LBR's. Annualized regional temperature and midyear UVB failed to demonstrate any relationship with LB following donor egg FET. Conclusion Our data suggest that ecological influences may relate to donor egg IVF cycle success. Future studies are needed to better elucidate the mechanisms that could explain the observed associations.

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Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors

Cited by 193 publications

References 45 publications

The Impact of Body Mass Index on ART Outcomes of High-Responders: Prospective Cohort Study

The Impact of Body Mass Index on ART Outcomes of High-Responders: Prospective Cohort Study

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Donor egg IVF model to assess ecological implications for ART success

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