Obesity rates in renal stone formers from various countries

Popov, Elenko; Almusafer, Murtadha; Belba, Arben; Bello, Jibril Oyekunle; Bhatti, Kamran Hassan; Boeri, Luca; Davidoff, Kaloyan; Hameed, B. M. Zeeshan; Halinski, Adam; Heilberg, Ita Pfeferman; Hui, Hongyi; Petkova, Kremena; Bapir, Rawa; Rodrigues, Fernanda Guedes; Saltirov, I.; Spivacow, Francisco Rodolfo; Trinchieri, Alberto; Buchholz, Noor

doi:10.4081/aiua.2021.2.189

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…evaluated the obesity rate (measured by BMI) of renal stone formers from different countries ( N = 10). In their study, Chinese renal stone patients had the lowest obesity rate (2%), and the obesity rate in Chinese renal stone formers was not higher than the obesity rate in general Chinese population [ 18 ]. In a cross-sectional study of 10,281 Chinese rural participants, Fan et al.…”

Section: Discussionmentioning

confidence: 99%

High perirenal fat thickness predicts a greater risk of recurrence in Chinese patients with unilateral nephrolithiasis

et al. 2023

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Introduction The aim of this study was to evaluate the association between recurrence-free survival (RFS) and perirenal fat thickness (PFT) in a cohort of Chinese population with unilateral nephrolithiasis. Methods We retrospectively reviewed the medical records of 81 patients with unilateral nephrolithiasis in our center from January 2019 to June 2019. PFT measured on computed tomography (CT) scans was evaluated. Kaplan-Meier curves and log-rank tests were used to assess significant differences in RSF between high-PFT and low-PFT groups within sexes. Univariable and multivariable Cox regression analyses were used to evaluate the potential risk factors for renal stone recurrence. Results High PFT was significantly associated with high BMI and hyperlipidemia ( p = .003 and.047, respectively). The PFT of stone-bearing kidney was significantly greater than PFT of non-stone-bearing kidney (0.77 ± 0.60 cm vs. 0.67 ± 0.58 cm, p = .002) . During the follow-up periods (median 31 months), 21 (25.9%) patients experienced ipsilateral renal stone recurrence. In addition, Kaplan–Meier survival curves showed that patients with low PFT had a significant better RFS than those with high PFT ( p = .012). In the univariable Cox analyses, male sex and high PFT were significantly associated with a poor RFS ( p = .042 and .018, respectively). Moreover, both male sex and high PFT retained significance in the multivariable analyses ( p = .045 and .020, respectively). Conclusions Our findings suggested that PFT is a noninvasive and feasible parameter, which may help in the risk stratification of renal stone recurrence in the follow-up periods.

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Section: Discussionmentioning

confidence: 99%

High perirenal fat thickness predicts a greater risk of recurrence in Chinese patients with unilateral nephrolithiasis

et al. 2023

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“…Nephrolithiasis represents a common disorder with a lifetime cumulative incidence of 5–10% and a progressively increasing prevalence worldwide [ 1 , 2 ], affecting all ages, sexes, and races, but frequently occurring between the 2nd and 4th decades of life [ 3 ]. Lithogenesis is characterized by an imbalance between the solubility and precipitation of minerals in the urine influenced by several factors, including climate, social-economic status, eating habits, obesity, genetic inheritance, and metabolic disorders [ 2 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. It is well established that stone formers (SF) exhibit a reduction of bone mineral density (BMD) [ 12 , 13 ], which may be exacerbated under low calcium intake [ 14 ], and histomorphometric studies have reported low bone formation and increased bone resorption [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Vascular Calcification Is Associated with Fetuin-A and Cortical Bone Porosity in Stone Formers

Rodrigues

Neves

Ormanji

et al. 2022

JPM

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Background: Nephrolithiasis has been associated with bone loss and vascular calcification (VC), reflecting abnormal extraosseous calcium deposition. Fetuin-A (Fet-A) acts as a potent inhibitor of ectopic mineralization. The aim of the present study was to evaluate the prevalence of VC in stone formers (SF) and non-stone formers (NSF) and to investigate potential determinants of VC among SF, including circulating levels of Fet-A and bone microarchitecture parameters. Methods: Abdominal aortic calcification (AAC) was assessed using available computed tomography in SF and in age-, sex-, and BMI-matched NSF (potential living kidney donors). Serum Fet-A was measured in stored blood samples from SF. Bone microarchitecture parameters were obtained as a post hoc analysis of a cross-sectional cohort from young SF evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT). Results: A total of 62 SF (38.0 [28.0–45.3] years old) and 80 NSF (40.0 [37.0–45.8] years old) were included. There was no significant difference in AAC scores between SF and NSF. However, when dividing SF according to mean AAC score, below <5.8% (n = 33) or above ≥5.8% (n = 29), SF with higher AAC presented significantly higher BMI and tibial cortical porosity (Ct.Po) and significantly lower serum HDL, klotho, Fet-A, and eGFR. Urinary calcium did not differ between groups, but fractional excretion of phosphate was higher in the former. Upon multivariate regression, BMI, serum Fet-A, and tibial Ct.Po remained independently associated with AAC. Conclusions: This study suggests an association between reduced circulating Fet-A levels and increased bone Ct.Po with VC in SF.

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Stone composition of renal stone formers from different global regions

Halinski

Bhatti

Boeri

et al. 2021

Arch Ital Urol Androl

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Objective: To study urinary stone composition patterns in different populations around the world. Materials and methods: Data were collected by reviewing charts of 1204 adult patients of 10 countries with renal or ureteral stones (> 18 years) in whom a stone analysis was done and available. Any method of stone analysis was accepted, but the methodology had to be registered. Results: In total, we observed 710 (59%) patients with calcium oxalate, 31 (1%) with calcium phosphate, 161 (13%) with mixed calcium oxalate/calcium phosphate, 15 (1%) with carbapatite, 110 (9%) with uric acid, 7 (< 1%) with urate (ammonium or sodium), 100 (9%) with mixed with uric acid/ calcium oxalate, 56 (5%) with struvite and 14 (1%) with cystine stones. Calciumcontaining stones were the most common in all countries ranging from 43 to 91%. Oxalate stones were more common than phosphate or mixed phosphate/oxalate stones in most countries except Egypt and India. The rate of uric acid containing stones ranged from 4 to 34%, being higher in Egypt, India, Pakistan, Iraq, Poland and Bulgaria. Struvite stones occurred in less than 5% in all countries except India (23%) and Pakistan (16%). Cystine stones occurred in 1% of cases. Conclusions: The frequency of different types of urinary stones varies from country to country. Calcium-containing stones are prevalent in all countries. The frequency of uric acid containing stones seems to depend mainly on climatic factors, being higher in countries with desert or tropical climates. Dietary patterns can also lead to an increase in the frequency of uric acid containing stones in association with high obesity rates. Struvite stones are decreasing in most countries due to improved health conditions.

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Obesity rates in renal stone formers from various countries

Cited by 3 publications

References 27 publications

High perirenal fat thickness predicts a greater risk of recurrence in Chinese patients with unilateral nephrolithiasis

High perirenal fat thickness predicts a greater risk of recurrence in Chinese patients with unilateral nephrolithiasis

Vascular Calcification Is Associated with Fetuin-A and Cortical Bone Porosity in Stone Formers

Stone composition of renal stone formers from different global regions

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