Concerning the genetic factors of obesity, no consistent association between
populations has been reported, which may be due to the frequency of polymorphisms,
the lifestyle of studied populations and its interaction with other factors. We
studied a possible association of polymorphisms FTO rs9939609,
PPARG rs1801282, and ADIPOQ rs4632532 and
rs182052 with obesity phenotypes in 215 Mexican children. Glucose, triglycerides,
cholesterol, HDL and LDL were measured. In addition, weight, height, waist
circumference and triceps skin thickness were recorded. High-energy diets and
sedentary behavior were evaluated with a validated questionnaire. In contrast with
other reports, only FTO rs9939609 was associated with obesity
related-traits, including BMI (p = 0.03), waist circumference
(p = 0.02), triceps skinfold (p = 0.03) and
waist/height ratio (p = 0.01), and also with cholesterol levels
(p = 0.02) and LDL (p = 0.009). Lower levels of
triglycerides (p=0.04) were related with presence of PPARG
rs1801282, while ADIPOQ rs4632532 showed an effect on HDL
(p = 0.03) levels. On the other hand, diet, physical activity and
screen time were not related with obesity. In summary, only FTO
rs9939609 was associated with obesity related-traits, while PPARG2
rs1801282 and ADIPOQ rs4632532 were involved in lipid
metabolism.