Obesity, Metabolic Syndrome and Disorders of Energy Balance

Weiss, Ram; Lustig, Robert H.

doi:10.1016/b978-0-323-62520-3.00024-5

Cited by 10 publications

(5 citation statements)

References 812 publications

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“…Both FGF-21 and FGF-19 have shown previous associations with BMI ( 50 , 51 , 52 , 53 ). FGF-21 and FGF-19 are hormones secreted broadly (FGF-21) and by the small intestine (FGF-19) ( 54 ); both play a critical role in regulating energy metabolism, glucose homeostasis, and lipid metabolism. Elevated circulating levels of FGF-21 are evident in individuals with obesity, insulin resistance, type 2 diabetes, and fatty liver disease ( 55 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling

Breithaupt,

Holsen,

et al. 2024

Biological Psychiatry Global Open Science

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Section: Discussionmentioning

confidence: 99%

Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling

Breithaupt,

Holsen,

et al. 2024

Biological Psychiatry Global Open Science

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“…BCAAs and AAAs are essential amino acids that account for more than 20% of the amino acids in a typical “Western diet” [ 46 ]. They are normally utilized for the biosynthesis of protein, but once provided in excess they are diverted away from protein synthesis and toward energy utilization.…”

Section: Discussionmentioning

confidence: 99%

Sargassum fusiforme Alginate Relieves Hyperglycemia and Modulates Intestinal Microbiota and Metabolites in Type 2 Diabetic Mice

Liu

Yang

et al. 2021

Nutrients

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Sargassum fusiforme alginate (SF-Alg) possess many pharmacological activities, including hypoglycemic and hypolipidemic. However, the hypoglycemic mechanisms of SF-Alg remain unclear due to its low bioavailability. In this study, we evaluated the therapeutic effect of SF-Alg on high-fat diet (HFD)/streptozotocin (STZ)-induced type 2 diabetes (T2D) mice. SF-Alg intervention was found to significantly reduce fasting blood glucose (FBG), triglycerides (TG), and total cholesterol (TC), while increasing high-density lipoprotein cholesterol (HDL-c) and improving glucose tolerance. In addition, administrating SF-Alg to diabetic mice moderately attenuated pathological changes in adipose, hepatic, and heart tissues as well as skeletal muscle, and diminished oxidative stress. To probe the underlying mechanisms, we further analyzed the gut microbiota using 16S rRNA amplicon sequencing, as well as metabolites by non-targeted metabolomics. Here, SF-Alg significantly increased some benign bacteria (Lactobacillus, Bacteroides, Akkermansia Alloprevotella, Weissella and Enterorhabdus), and significantly decreased harmful bacteria (Turicibacter and Helicobacter). Meanwhile, SF-Alg dramatically decreased branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) in the colon of T2D mice, suggesting a positive benefit of SF-Alg as an adjvant agent for T2D.

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“…76 In pre-clinical rodent studies, CD40 signaling has been shown to contribute to the progression of obesity-related complications such as insulin resistance and cardiovascular disease. 77 FGF-21 and FGF-19 are hormones secreted broadly (FGF-21) and by the small intestine (FGF-19); 78 both play a critical role in regulating energy metabolism, glucose homeostasis, and lipid metabolism. Elevated circulating levels of FGF-21 are evident in individuals with obesity, particularly in those with obesity-related metabolic disorders such as insulin resistance, type 2 diabetes, and fatty liver disease.…”

Section: Twenty-seven Proteins Are Correlated With Bmi Across Samplementioning

confidence: 99%

Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation Associated Biomarkers Using Multiplex Profiling in Anorexia Nervosa and Atypical Anorexia Nervosa

Breithaupt,

Holsen,

et al. 2023

Preprint

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Proteomics provides an opportunity for detection and monitoring of anorexia nervosa (AN) and its related variant, atypical-AN (atyp-AN). However, research to date has been limited by the small number of proteins explored, exclusive focus on adults with AN, and lack of replication across studies. This study performed Olink Proseek Multiplex profiling of 92 proteins involved in inflammation among females with AN and atyp-AN (N = 64), all < 90% of expected body weight, and age-matched healthy controls (HC; N=44). After correction for multiple testing, nine proteins differed significantly in the AN/atyp-AN group relative to HC group (lower levels: CXCL1, HGF, IL-18R1, TNFSF14, TRANCE; higher levels: CCL23, Flt3L, LIF-R, MMP-1). The expression levels of three proteins (lower IL-18R1, TRANCE; higher LIF-R) were uniquely disrupted in females with AN. No unique expression levels emerged for atyp-AN. Across the whole sample, twenty-one proteins correlated positively with BMI (ADA, AXIN1, CD5, CD244, CD40, CD6, CXCL1, FGF-21, HGF, IL-10RB, IL-12B, IL18, IL-18R1, IL6, LAP TGF-beta-1, SIRT2, STAMBP, TNFRSF9, TNFSF14, TRAIL, TRANCE) and six (CCL11, CCL23, FGF-19, IL8, LIF-R, OPG) were negatively correlated with BMI. Overall, our results replicate the prior study demonstrating a dysregulated inflammatory status in AN, and extend these results to atyp-AN (AN/atyp-AN all < 90% of expected body weight). Of the 27 proteins correlated with BMI, 18 were replicated from a prior study using similar methods, highlighting the promise of inflammatory protein expression levels as biomarkers of disease monitoring. Additional studies of individuals across the entire weight spectrum are needed to understand the role of inflammation in atyp-AN.

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Obesity, Metabolic Syndrome and Disorders of Energy Balance

Cited by 10 publications

References 812 publications

Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling

Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling

Sargassum fusiforme Alginate Relieves Hyperglycemia and Modulates Intestinal Microbiota and Metabolites in Type 2 Diabetic Mice

Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation Associated Biomarkers Using Multiplex Profiling in Anorexia Nervosa and Atypical Anorexia Nervosa

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