Obesity Markers as Predictors for Colorectal Neoplasia

Abstract

Background The goal of this study was to determine the relations between the risk of colorectal neoplasia and obesity markers: body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR). Methods The subjects who underwent screening colonoscopies at a Kyungpook National University Hospital in Daegu from July to December 2010 were enrolled. We defined colorectal neoplasia as tubular adenoma, advanced adenoma, or cancer. We performed a logistic regression analysis to investigate the correlations between obesity and colorectal neoplasia and a receiver operating characteristic (ROC) curve analysis to determine the cut-off obesity marker values for detecting colorectal neoplasia. Results Among the total of 268 subjects, 83 (31.0%) subjects had colorectal neoplasia. Subjects with neoplasia had higher BMI, WC, and WHtR than the subjects without any neoplasia. The adjusted odds ratio (aOR) of WHtR ≥0.5 with the association of neoplasia was 1.927 (95% confidence interval [CI], 1.041–3.569) in the total subjects. In women, the obesity markers of WC ≥85 cm (aOR 4.611; 95% CI, 10.166–18.240) and WHtR ≥0.5 (aOR 1.747; 95% CI, 1.149–19.617) were significantly related to neoplasia; however, there was no significant result in men. The ROC analysis showed the optimal cut-off values of BMI as >23.14 kg/m 2 ( P =0.002), WHtR as >0.50 ( P <0.001), and WC as>82.5 cm ( P =0.650) in men and >77 cm in women ( P <0.001). Conclusion Obesity is significantly associated with the increased risk of colorectal neoplasia. WC and WHtR have more significant correlations with neoplasia; thus, obese people should undergo regular colonoscopy screenings to detect colorectal neoplasia.

Nutritional and functional status as indices of short- and long-term prognosis in patients undergoing surgery due to colorectal cancer

“…However, the present observation is consistent with the report by Nattenmueller et al [25], who found that WHtR was a better predictor of adipose tissue compartments and SMM than BMI and waist-to-hip ratio (WHR), although, compared to the CT-based measurement, WHtR did not adequately capture differences according to age and gender. Nevertheless increased WHtR with different cut-offs is recognized as a risk factor and/or prognostic parameter in numerous clinical conditions, such as thyroid cancer (WHtR ≥ 0.5) [31], primary liver cancer [32,33], prostate cancer (WHtR > 0.59 or ≥ 0.6 [34]), gallbladder cancer [35], breast cancer [1,36], kidney cancer in postmenopausal women [37], all obesity-related cancers (WHtR ≥ 0.51 in men, and ≥ 0.57 in women) [1,38], CRC (WHtR ≥ 0.55 [39] or ≥ 0.5 [40]), and prognosis after CRC surgery [41]. Moreover, increased WHtR is a better predictor for the risk of metabolic disorders (diagnostic value in descending order: WHtR > WHR > WC > BMI) [42].…”

Are Obesity and Adenoma Development Associated as Colorectal Cancer Precursors?

“…In relation to the presence of pre-malignant lesions in obese patients, the proportion was higher than in individuals of normal weight or overweight, since 47.8% of this population had adenomatous lesions. Studies indicate that obesity is associated with an increase in the prevalence of benign colorectal neoplasia and, consequently, of CRC 13 , 15 , 23 . A meta-analysis conducted in westerners showed that the increase in BMI by 5 kg/m 2 increased the risk of colorectal adenomas by 1.19 times, and also by CRC by 1.13 and 1.06 times in men and women, respectively 19 .…”

Prevalência De Obesidade Em Pacientes Dispépticos Atendidos Em Um Serviço Público De Endoscopia Em Imperatriz-Ma

“…O tecido adiposo em excesso observado na obesidade, bem como as mudanças anatômicas, provoca alterações que impactam o sistema digestivo de modo microscópico e global (NAM, 2017). Sobrepeso e obesidade estão envolvidos no aumento do risco de um amplo espectro de doenças digestivas, como doença do refluxo gastroesofágico, esôfago de Barrett, esofagite erosiva, doença hepática gordurosa não alcoólica, cálculos biliares e pancreatite, além de cânceres de órgãos digestivos, como colangiocarcinoma, carcinoma hepatocelular, câncer pancreático, câncer colorretal e câncer de esôfago (FUJIHARA et al,2012;KWON et al, 2017;TAHERGORABI et al, 2018).…”