Obesity is Independently Associated With Worse Patient‐Reported Outcomes in Women with Systemic Lupus Erythematosus

Patterson, Susan; Schmajuk, Gabriela; Jafri, Kashif; Yazdany, Jinoos; Katz, Patricia P.

doi:10.1002/acr.23576

Cited by 44 publications

(44 citation statements)

References 45 publications

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“…Corticosteroids remain the first choice of treatment for SLE, but their administration is linked to excess weight gain and the development of corticosteroid-induced diabetes. Obesity was detected as an independent risk factor in worsening the functional capacity, fatigue, and inflammation status of patients with SLE ( 20 , 22 – 24 ).…”

Section: Macronutrientsmentioning

confidence: 99%

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

et al. 2020

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Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ involvement, including the skin, joints, kidneys, lungs, central nervous system and the haematopoietic system, with a large number of complications. Despite years of study, the etiology of SLE remains unclear; thus, safe and specifically targeted therapies are lacking. In the last 20 years, researchers have explored the potential of nutritional factors on SLE and have suggested complementary treatment options through diet. This study systematically reviews and evaluates the clinical and preclinical scientific evidence of diet and dietary supplementation that either alleviate or exacerbate the symptoms of SLE. For this review, a systematic literature search was conducted using PubMed, Scopus and Google Scholar databases only for articles written in the English language. Based on the currently published literature, it was observed that a low-calorie and low-protein diet with high contents of fiber, polyunsaturated fatty acids, vitamins, minerals and polyphenols contain sufficient potential macronutrients and micronutrients to regulate the activity of the overall disease by modulating the inflammation and immune functions of SLE.

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Section: Macronutrientsmentioning

confidence: 99%

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

et al. 2020

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“…Obesity has been known to influence major symptoms of autoimmune‐induced arthritis significantly, particularly pain, fatigue, and depression (Katz et al, ; Patterson et al, ). However, in the present study, obesity had a significant influence on only fatigue.…”

Section: Discussionmentioning

confidence: 99%

“…For symptom experience, we focused on the most frequent and distressing symptoms (pain, fatigue, and depression), rather than all potential symptoms, so as to keep the hypothetical model concise with adequate yet minimal numbers of symptoms. Disease activity and obesity were included as antecedents of symptom experience because they have been shown to influence RA symptoms, particularly pain, fatigue, and depression, significantly (Katz et al, ; Patterson, Schmajuk, Jafri, Wysham, & Katz, ). In terms of the outcomes of symptom experience, quality of life was included as the outcome of the synergistic effects of symptom clusters because RA is primarily a quality‐of‐life issue.…”

Section: Introductionmentioning

confidence: 99%

Identification of symptom clusters and their synergistic effects on quality of life in rheumatoid arthritis patients

Park

Seo

2018

Int J of Nursing Practice

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Aims To examine the presence of symptom clusters and synergistic effects of symptom clusters on quality of life in rheumatoid arthritis patients. Background Rheumatoid arthritis patients frequently experience multiple concurrent symptoms of pain, fatigue, and depression. Design A nonexperimental, cross‐sectional correlation design. Methods The study participants were 179 rheumatoid arthritis patients. Data were collected between August and December 2016. A hypothetical model was developed based on the Theory of Unpleasant Symptoms Model: physiological antecedents included disease activity and obesity; symptoms of pain, fatigue, and depression were hypothesized as being clustered, and quality of life was taken as the outcome variable. Results Disease activity had significant direct effects on pain, fatigue, and depression and indirect effects on fatigue and depression, whereas obesity had a significant direct effect on fatigue alone. Three symptom clusters, namely, pain fatigue, fatigue depression, and pain‐fatigue depression were identified and found to have significant synergistic effects on quality of life. Conclusions Our findings support the importance of managing clusters of symptoms simultaneously, that is, collective symptom management. Inter‐cluster dynamics between symptoms should be considered when nurses develop symptom management strategies or self‐management programs to improve the quality of life of rheumatoid arthritis patients.

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“…[11][12][13][14] Also, obesity has been associated with increased fatigue both in the general population and SLE. 15 A full clinical examination of the heart, lung, thyroid and nervous system 16 is crucial. For women, a gynaecological examination is also recommended, especially in case of anaemia.…”

Section: Step 1: Search For a General (Non-lupus-related) Cause Of Famentioning

confidence: 99%

Towards a practical management of fatigue in systemic lupus erythematosus

et al. 2020

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Significant fatigue is reported by two-thirds of patients with SLE and severe fatigue by one-third. The assessment and treatment of fatigue remains a major challenge in SLE, especially in patients with no disease activity. Here, we suggest a practical algorithm for the management of fatigue in SLE. First, common but non–SLE-related causes of fatigue should be ruled out based on medical history, clinical and laboratory examinations. Then, presence of SLE-related disease activity or organ damage should be assessed. In patients with active disease, remission is the most appropriate therapeutic target while symptomatic support is needed in case of damage. Both anxiety and depression are major independent predictors of fatigue in SLE and require dedicated assessment and care with psychological counselling and pharmacological intervention if needed. This practical algorithm will help in improving the management of one the most common and complex patient complaints in SLE.

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Obesity is Independently Associated With Worse Patient‐Reported Outcomes in Women with Systemic Lupus Erythematosus

Cited by 44 publications

References 45 publications

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

Identification of symptom clusters and their synergistic effects on quality of life in rheumatoid arthritis patients

Towards a practical management of fatigue in systemic lupus erythematosus

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