Obesity is associated with colitis in women but not necessarily causal relationship

Shen, Wei; He, Lianping; Zhou, Lingling

doi:10.12998/wjcc.v10.i26.9542

Cited by 2 publications

(2 citation statements)

References 6 publications

(6 reference statements)

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“…1,2 The constitution of diabetes in China is mainly type 2 diabetes (T2DM), and long-term elevated blood sugar can lead to eye, kidney, heart, blood vessels, nerve chronic damage and dysfunction. [2][3][4] Diabetic nephropathy is one of the most important complications of diabetic patients, which is featured by progressive reduction of proteinuria and glomerular filtration rate (GFR). There are no obvious symptoms in the early stage of the disease.…”

Section: Introductionmentioning

confidence: 99%

Differences and Clinical Significance of Serum 25-Hydroxyvitamin D3 and Vasohibin-1 (VASH-1) Levels in Patients with Diabetic Nephropathy and Different Renal Injuries

Liu¹,

Wang²,

Tang³

et al. 2023

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Objective We investigate the relationship between the changes of serum 25-hydroxyvitamin D3 (25(OH)D3) and vasohibin-1 (VASH-1) and renal function injury in patients with type 2 diabetic nephropathy. Methods In this study, 143 patients with diabetic nephropathy (DN) were selected as DN group, and 80 patients with type 2 diabetes mellitus were selected as T2DM group. The serum 25 (OH) D3, VASH-1, blood glucose index, inflammation index and renal function index were compared between the two groups. According to the urinary microalbumin/creatinine ratio (UACR), the DN group was divided into microalbuminuria group (UACR range≥30.0mg/g and <300.0mg/g) and macroalbuminuria group (UACR≥300.0mg/g) for stratified comparison. The correlation between 25-hydroxyvitamin D3, VASH-1 and inflammation index and renal function index was analyzed by simple linear correlation analysis. Results The level of 25 (OH) D3 in DN group was significantly lower than that in T2DM group (P<0.05). The levels of VASH-1, CysC, BUN, Scr, 24h urine protein, serum CRP, TGF-β1, TNF-α and IL-6 in DN group were higher than those in T2DM group (P<0.05). The level of 25 (OH) D3 in DN patients with massive proteinuria was significantly lower than that in DN patients with microalbuminuria. The level of VASH-1 in DN patients with massive proteinuria was higher than that in DN patients with microalbuminuria (P<0.05). There was a negative correlation between 25 (OH) D3 and CysC, BUN, Scr, 24h urine protein, CRP, TGF-β1, TNF-α, IL-6 in patients with DN (P<0.05). VASH-1 was positively correlated with Scr, 24h urinary protein, CRP, TGF-β1, TNF-α and IL-6 in patients with DN (P<0.05). Conclusion The level of serum 25 (OH) D3 in DN patients was considerably decreased, and the level of VASH-1 was increased, which was related to the degree of renal function injury and inflammatory response.

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Section: Introductionmentioning

confidence: 99%

Differences and Clinical Significance of Serum 25-Hydroxyvitamin D3 and Vasohibin-1 (VASH-1) Levels in Patients with Diabetic Nephropathy and Different Renal Injuries

Liu¹,

Wang²,

Tang³

et al. 2023

DMSO

View full text Add to dashboard Cite

show abstract

“…Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes in adults, accounting for about 95% of all people with diabetes [3]. The mutual interaction between the patient's genetic background and lifestyle and social and environmental factors (e.g., obesity, physical inactivity) is closely linked to the development of T2DM [4][5][6][7][8][9]. T2DM is primarily characterized by impaired insulin secretion and islet beta-cell failure (loss of beta-cell quality or function) [10].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D May Play a Vital Role in Alleviating Type 2 Diabetes Mellitus by Modulating the Ferroptosis Signaling Pathway

et al. 2023

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Ferroptosis is an iron-dependent death mode mediated by the aggregation of lipid peroxides and lipid-reactive oxygen species. It is characterized by iron-dependent lipid peroxide accumulation accompanied by oxidoreductase deficiency. Pancreatic beta cell dysfunction and insulin resistance are two major causes of type 2 diabetes mellitus (T2DM). Iron accumulation and metabolism may play a role in the development of T2DM. The molecular mechanism of β cell apoptosis and iron death in T2DM were reviewed. In addition, we discuss recent insights on the relationship between the trace element iron and apoptosis of β cells in T2DM.

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Obesity is associated with colitis in women but not necessarily causal relationship

Abstract: The relationship between obesity and female risk of microscopic colitis remains to be discussed.

Cited by 2 publications

References 6 publications

Differences and Clinical Significance of Serum 25-Hydroxyvitamin D3 and Vasohibin-1 (VASH-1) Levels in Patients with Diabetic Nephropathy and Different Renal Injuries

Differences and Clinical Significance of Serum 25-Hydroxyvitamin D3 and Vasohibin-1 (VASH-1) Levels in Patients with Diabetic Nephropathy and Different Renal Injuries

Vitamin D May Play a Vital Role in Alleviating Type 2 Diabetes Mellitus by Modulating the Ferroptosis Signaling Pathway

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