Obesity, insulin resistance and their interaction on liver enzymes

Liu, Chenbing; Shao, Min; Lu, Ling; Zhao, Chenzhao; Qiu, Lihong; Liu, Zhong

doi:10.1371/journal.pone.0249299

Cited by 26 publications

(22 citation statements)

References 35 publications

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“…The dramatic increase in obesity remained challenging worldwide, and it has been estimated that about 40% of world population will be overweight and 20% will be obese by 2030 1 2 . Obesity is a well‐known risk factor for metabolic syndrome which may lead to chronic diseases such as diabetes, cardiovascular diseases and non‐alcoholic fatty liver disease (NAFLD) 3,4 .…”

Section: Introductionmentioning

confidence: 99%

The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women

Jalili

Poorahmadi

Ardekanizadeh

et al. 2022

Endocrino Diabet & Metabol

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Background: Obesity-induced inflammation may independently disturb the function of critical organs such as liver. This study aimed to investigate the association of obesity with serum levels of biomarkers of liver function including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) in adult women. Methods:This cross-sectional study was carried out on 360 adult women in the summer of 2020 in Tehran, Iran. The participants were categorized into two groups based on their body mass index (BMI≤29.9 and BMI > 30). The serum levels of ALT, AST, ALP How to cite this article: Jalili V, Poorahmadi Z, Hasanpour Ardekanizadeh N, et al. The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transferase in adult women.

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Section: Introductionmentioning

confidence: 99%

The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women

Jalili

Poorahmadi

Ardekanizadeh

et al. 2022

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

show abstract

“…HFD-G is widely used in the animal model of diabetes induction by inducing hyperglycemia and insulin resistance. Studies have shown that prolonged administration of a high-fat diet may inhibit the insulin receptor signaling pathway and trigger insulin resistance ( 27 , 28 ). A high-fat diet will increase the formation of diacylglycerol (DAG) in the liver and muscles over time.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D supplementation alleviates insulin resistance in prediabetic rats by modifying IRS-1 and PPARγ/NF-κB expressions

et al. 2023

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BackgroundPrediabetes is a condition of intermediate hyperglycemia that may progress to type 2 diabetes. Vitamin D deficiency has been frequently linked to insulin resistance and diabetes. The study aimed to investigate the role of D supplementation and its possible mechanism of action on insulin resistance in prediabetic rats.MethodThe study was conducted on 24 male Wistar rats that were randomly divided into 6 rats as healthy controls and 18 prediabetic rats. Prediabetic rats were induced with a high-fat and high-glucose diet (HFD-G) combined with a low dose of streptozotocin. Rats with the prediabetic condition were then randomized into three groups of 12-week treatment: one group that received no treatment, one that received vitamin D3 at 100 IU/kg BW, and one group that received vitamin D3 at 1000 IU/kg BW. The high-fat and high-glucose diets were continuously given throughout the twelve weeks of treatment. At the end of the supplementation period, glucose control parameters, inflammatory markers, and the expressions of IRS1, PPARγ, NF-κB, and IRS1 were measured.ResultsVitamin D3 dose-dependently improves glucose control parameters, as shown by the reduction of fasting blood glucose (FBG), oral glucose tolerance test (OGTT), glycated albumin, insulin levels, and markers of insulin resistance (HOMA-IR). Upon histological analysis, vitamin D supplementation resulted in a reduction of the islet of Langerhans degeneration. Vitamin D also enhanced the ratio of IL-6/IL-10, reduced IRS1 phosphorylation at Ser307, increased expression of PPAR gamma, and reduced phosphorylation of NF-KB p65 at Ser536.ConclusionVitamin D supplementation reduces insulin resistance in prediabetic rats. The reduction might be due to the effects of vitamin D on IRS, PPARγ, and NF-κB expression.

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“…SUA promotes oxidative stress and systemic inflammation directly or via lipid and glucose metabolism, leading to hepatocyte death and steatohepatitis [ 14 , 40 , 41 ]. BMI increases are associated with steatosis and NAFLD via inflammation [ 42 , 43 ]. The mechanisms by which the BMI modifies the association between the SUA level and liver function are unclear, but steatosis and inflammation may be implicated.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effect of serum uric acid and body mass index trajectories during middle to late childhood on elevation of liver enzymes in early adolescence: Findings from the Ewha Birth and Growth Study

et al. 2023

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Background/objectives We aimed to determine whether serum uric acid (SUA) and body mass index (BMI) trajectories in childhood have longitudinal association with liver enzymes in adolescence. Methods We conducted a study using data from the Ewha Birth and Growth Cohort. Individual trajectories of SUA (n = 203) and BMI (n = 206) from 5, 7, and 9 years were defined by group-based trajectory modeling. Also, liver function enzymes were collected at 11 to 12 year of age (Aspartate Aminotransferase [AST], Alanine transaminase [ALT], and Gamma-glutamyl transferase [γ–GTP]) (n = 206). Using a generalized linear model, the effects of SUA trajectory and BMI trajectory on liver function enzymes were assessed. We also assessed the interaction effect of SUA and BMI trajectories on liver enzymes. Results For trajectory patterns, both SUA and BMI were classified into two distinct groups (High or Low). Both trajectory of SUA and BMI in childhood were positively associated with levels of liver enzymes at 11–12 years of age. The results showed that the combined effect of SUA and BMI trajectories on liver enzymes had a higher means in high-risk group (high SUA–high BMI trajectories group) than in low-risk group (low SUA-low BMI trajectories group) for ALT and γ–GTP, respectively. It remained significant association when adjusted for covariates. In addition, the interaction of BMI and SUA trajectories showed a significant synergistic effect. Conclusion Elevated childhood SUA and BMI trajectories are associated with increased liver enzymes in beginning of adolescent. This finding suggesting that early interventions in SUA and BMI may need for optimization of liver enzymes as potential marker for development of related disease in later life.

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Obesity, insulin resistance and their interaction on liver enzymes

Cited by 26 publications

References 35 publications

The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women

The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women

Vitamin D supplementation alleviates insulin resistance in prediabetic rats by modifying IRS-1 and PPARγ/NF-κB expressions

Synergistic effect of serum uric acid and body mass index trajectories during middle to late childhood on elevation of liver enzymes in early adolescence: Findings from the Ewha Birth and Growth Study

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