Obesity, inflammation, and asthma severity in childhood: data from the National Health and Nutrition Examination Survey 2001-2004

Michelson, Peter H.; Williams, Larry W.; Benjamin, Daniel K.; Barnato, Amber E.

doi:10.1016/s1081-1206(10)60356-0

Cited by 84 publications

(67 citation statements)

References 25 publications

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“…The present study showed that obesity was significantly associated with more severe childhood asthma. This finding is consistent with that reported in previous studies [23][24][25].…”

Section: Discussionsupporting

confidence: 94%

Association between dietary habits and asthma severity in children

et al. 2015

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Objective: To investigate association between dietary habits and asthma severity in children.Design: Cross-sectional study. Setting: Two teaching hospitals in Brazil.Participants: Cases (n=268) were children (3-12yr) with persistent asthma and age-matched controls (n=126) were those with intermittent asthma. Main outcome measures:Dietary habits were determined based on food consumption in the past 12 months classified as frequent (≥3 times per week) or infrequent (never or <3 times per week).Nutritional status was classified into two categories according to WHO Child Growth Standards: obese: >2Z-score of BMI-for-age; non-obese: ≤2Z-score of BMI-for-age.Results: After adjusting for confounding factors, maternal smoking during pregnancy, preterm birth and obesity were significantly associated with persistent asthma, with adjusted ORs (95% CI) of 2.11 (1.08-4.13), 2.61(1.07-6.35) and 2.89 (1.49-5.61), respectively. No significant association was observed between frequency of consumption of specific foods, food groups, or dietary pattern (pro-or contra-Mediterranean diet) and the severity of asthma. Conclusions:This study did not find a significant association between dietary habits and asthma severity in children. Maternal smoking during pregnancy, preterm birth and obesity were independent factors associated with persistent asthma.

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“…The present study showed that obesity was significantly associated with more severe childhood asthma. This finding is consistent with that reported in previous studies [23][24][25].…”

Section: Discussionsupporting

confidence: 94%

Association between dietary habits and asthma severity in children

et al. 2015

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“…While it is reasonable to assume that compromised health in childhood may carry an inflammatory load that persists into adulthood, this relationship may be disease and severity dependent. Prior studies have shown a link between childhood asthma and inflammation (Michelson et al, 2009); however, in our sample the majority of the negative health conditions that were reported were ear problems or respiratory problems. Furthermore, of those reporting respiratory problems, none reported concurrent asthma.…”

Section: Discussioncontrasting

confidence: 72%

Childhood and Later Life Stressors and Increased Inflammatory Gene Expression at Older ages

2016

The Gerontologist

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Adverse experiences in early life have the ability to "get under the skin" and affect future health. This study examined the relative influence of adversities during childhood and adulthood in accounting for individual differences in pro-inflammatory gene expression in late life. Using a pilot-sample from the Health and Retirement Study (N=114) aged from 51-95, OLS regression models were run to determine the association between a composite score from three proinflammatory gene expression levels (PTGS2, ILIB, and IL8) and 1) childhood trauma, 2) childhood SES, 3) childhood health, 4) adult traumas, and 5) low SES in adulthood. Our results showed that only childhood trauma was found to be associated with increased inflammatory transcription in late life. Furthermore, examination of interaction effects showed that childhood trauma exacerbated the influence of low SES in adulthood on elevated levels of inflammatory gene expression-signifying that having low SES in adulthood was most damaging for persons who had experienced traumatic events during their childhood. Overall our study suggests that traumas experienced during childhood may alter the stress response, leading to more sensitive reactivity throughout the lifespan. As a result, individuals who experienced greater adversity in early life may be at higher risk of late life health outcomes, particularly if adulthood adversity related to SES persists.

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“…5 Children with asthma from urban environments exhibit increased obesity prevalence rates, and obesity has been associated with abnormal lung function, increased asthma symptoms and poor asthma control. [8][9][10][11] Although asthma is a common and costly cause for pediatric hospitalization, the impact of obesity on admissions for status asthmaticus in urban children is not completely understood. Retrospective studies using large administrative databases have found obesity was associated with longer length of stay (LOS) and hospital charges in children admitted with asthma.…”

Section: Resultsmentioning

confidence: 99%

“…10,28,29 Others hypothesize that chronic inflammation and oxidative stress in obesity may be the link between asthma and obesity. 11,30 Abnormal lung function may be further complicated by a decreased response to both corticosteroids and bronchodilators in overweight children. 31,32 Our study strengthens similar findings of poor control in obese patients with asthma in other studies [33][34][35] because it assesses a wider age range, uses chart review, and controls for asthma severity.…”

Section: Discussionmentioning

confidence: 99%

Impact of Obesity on Clinical Outcomes in Urban Children Hospitalized for Status Asthmaticus

Aragona

El-Magbri

Wang

et al. 2016

Hospital Pediatrics

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A B S T R A C T BACKGROUND AND OBJECTIVE:The prevalence of both childhood asthma and obesity remain at historically high levels and disproportionately affect urban children. Asthma is a common and costly cause for pediatric hospitalization. Our objective was to determine the effect of obesity on outcomes among urban children hospitalized with status asthmaticus. METHODS:A retrospective cohort study was performed by using billing system data and chart review to evaluate urban children admitted for asthma. Demographics, asthma severity, reported comorbidities, and outcomes were assessed. Obesity was defined by BMI percentile (lean ,85%, overweight 85%-95%, obese $95%). Outcomes were length of stay, hospitalization charges, ICU stay, repeat admissions, and subsequent emergency department (ED) visits. Bivariate analysis assessed for differences between overweight/obese and lean children. Multivariable regression assessed the relationship between overweight status and primary outcomes while controlling for other variables. Post hoc age-stratified analysis was also performed. RESULTS:The study included 333 subjects; 38% were overweight/obese. Overweight/obese children admitted with asthma were more likely than lean children to have subsequent ED visits (odds ratio 1.6, 95% confidence interval 1.0-2.6). When stratified by age, overweight/obese preschool-age children (,5 years) were .2 times as likely to have repeat ED visits than lean preschool-age children (odds ratio 2.3, 95% confidence interval 1.0-5.6). There were no differences in the other outcomes between overweight/obese and lean individuals within the entire cohort or within other age groups.

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Obesity, inflammation, and asthma severity in childhood: data from the National Health and Nutrition Examination Survey 2001-2004

Cited by 84 publications

References 25 publications

Association between dietary habits and asthma severity in children

Association between dietary habits and asthma severity in children

Childhood and Later Life Stressors and Increased Inflammatory Gene Expression at Older ages

Impact of Obesity on Clinical Outcomes in Urban Children Hospitalized for Status Asthmaticus

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