Obesity increases the prevalence and the incidence of asthma and worsens asthma severity

Barros, Renata; Moreira, Pedro; Padrão, Patrícia; Teixeira, Vítor Hugo; Carvalho, Pedro; Delgado, Luís; Moreira, André

doi:10.1016/j.clnu.2016.06.023

Cited by 76 publications

(51 citation statements)

References 37 publications

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“…While some of this increased prevalence of obesity within the severe asthma population may reflect the obesogenic effects of the systemic corticosteroids that are widely used in this population, there is also evidence that obesity increases the severity of asthma. For example, in the Portugese National Health Survey of over 30,000 individuals, overweight (25.0–29.9 kg/m 2 ), class I obesity (30.0–34.9 kg/m 2 ), class II obesity (35.0–39.9 kg/m 2 ), and class III obesity (≥40.0 kg/m 2 ) were associated with odds ratios (OR) for severe asthma (defined as an emergency room visit for asthma within the last 12 months) of 1.36, 1.50, and 3.70, respectively (28). Similarly, in a study of almost 30,000 U.S. adults and children with persistent asthma, higher body mass index (BMI) was associated with increased risk of asthma exacerbations, defined as oral corticosteroid dispensings linked to an asthma encounter (29).…”

Section: Obesity Increases the Severity Of Asthmamentioning

confidence: 99%

Obesity and severe asthma

Tashiro

Shore

2019

Allergology International

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Obesity is an important global health issue for both children and adults. Obesity increases the prevalence and incidence of asthma and also increases the risk for severe asthma. Here we describe the features of severe asthma phenotypes for which obesity is a defining characteristic, including steroid resistance, airway inflammation, and co-morbidities. We also review current concepts regarding the mechanistic basis for the impact of obesity in severe asthma, including possible roles for vitamin D deficiency, systemic inflammation, and the microbiome. Finally, we describe data indicating a role for diet, weight loss, and exercise in the treatment of severe asthma with obesity. Better understanding of the mechanistic basis for the role of obesity in severe asthma could lead to new therapeutic options for this population.

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Section: Obesity Increases the Severity Of Asthmamentioning

confidence: 99%

Obesity and severe asthma

Tashiro

Shore

2019

Allergology International

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“…Snacks included: fruit; bread or sandwiches; milk and dairy; juices and soft drinks; pastry, chocolates or sweet desserts; other candies; salty snacks; chips; and alcoholic beverages. Based on this list, five dietary patterns were defined by latent trait models, as described elsewhere [26,27]. Briefly, the ‘dairy and fruit' dietary pattern was positively correlated with fruit, milk, and dairy products.…”

Section: Participants and Methodsmentioning

confidence: 99%

Body Mass Index Categories and Attained Height in Portuguese Adults

et al. 2018

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Objective: To analyze the associations between height and BMI categories in a Portuguese representative sample. Methods: This is a cross-sectional study with a representative sample of 32,644 Portuguese adults (52.4% females). Sociodemographic and lifestyle characteristics were obtained along with self-reported height and weight. We performed generalized linear models to assess the differences in attained height across BMI categories; analyses were adjusted for age, gender, education, family income per month, proxy reporting information, dietary patterns, and smoking. Results: BMI categories included underweight and normal weight (46.4%), overweight (37.6%), obese class I and II (15.2%), and obese class III (0.8%). Adults with normal weight had a significantly higher height (females +7 cm and males +5 cm) when compared to obese class III. As BMI categories increased, height decreased. In females and males, after adjusting for confounders, estimates of attained height decreased when compared to the unadjusted model (β = -0.049, 95% CI = -0.050; -0.049 and β = -0.030, 95% CI = -0.031; -0.029, respectively), although they remained still significant. Conclusion: Our results suggest a significant difference in attained height between BMI categories. Future intervention programs aiming at preventing overweight and obesity should monitor sociodemographic, health and environmental conditions that affect attained height potential.

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“…There is evidence that obesity increases the risk of developing asthma (38)(39)(40)(41). Generally, obese-asthma patients present decreased levels of airway eosinophilic inflammation, increased symptoms, risk of hospitalization, healthcare-associated costs and poor response to CS (39,40). Several proposed mechanisms suggest the pro-inflammatory role of adipocytes, that can lead to the development of airway inflammation and asthma (38).…”

Section: The Obesity-related Asthma Phenotypementioning

confidence: 99%

Metabolic interactions in asthma

Farraia

Rufo

Paciência

et al. 2019

Eur Ann Allergy Clin Immunol

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Metabolomics can be used to explore altered metabolic pathways in asthma, giving insights into its pathophysiology. We aimed to review how metabolomics has been used to understand asthma by describing metabolic pathways under research and discussing clinical implications. The search was performed in PubMed, and studies published since 2000 using a metabolomics approach, were included. A total of 32 studies were analysed. Pathways related with cellular energy homeostasis, lipid metabolism and oxidative stress, immune and inflammatory processes and others were altered. Initial studies focused on biomarker discovery. But metabolomics can be used to evaluate drug effects on specific pathways, to highlight pathways that can further develop in new targeted treatments, and to identify differences according to asthma severity and phenotypes.Abbreviations BALF, bronchoalveolar lavage fluid; CS, corticosteroid; EBC, exhaled breath condensate; GCxGC-TOF/MS, two-dimensional gas chromatography with time-of-flight mass spectrom-

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Obesity increases the prevalence and the incidence of asthma and worsens asthma severity

Cited by 76 publications

References 37 publications

Obesity and severe asthma

Obesity and severe asthma

Body Mass Index Categories and Attained Height in Portuguese Adults

Metabolic interactions in asthma

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