Obesity in the Pediatric Headache Population: A Multicenter Study

Hershey, Andrew D.; Powers, Scott W.; Nelson, Timothy D.; Kabbouche, Marielle A.; Winner, Paul; Yonker, Marcy; Linder, Steven L.; Bicknese, Alma R.; Sowel, Michael K.; McClintock, W.

doi:10.1111/j.1526-4610.2008.01232.x

Cited by 124 publications

(119 citation statements)

References 19 publications

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“…Data regarding effects of obesity and headaches in children are more limited. However, an increasing number of reports suggest that obesity could also be a risk factor for migraine in the paediatric population [38][39][40]. Our study confirmed these findings.…”

Section: Discussionsupporting

confidence: 89%

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Sordyl

Kopyta

Sarecka-Hujar

et al. 2019

aoms

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A b s t r a c tIntroduction: Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idiopathic headaches. Material and methods: The study population comprised 65 children (39 with idiopathic headaches and 26 healthy children). Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triacylglycerol (TG) levels were measured in every patient. Brain-derived neurotrophic factor (BDNF), soluble CD40 ligand (sCD40L), endothelial plasminogen activator inhibitor (serpin E1/PAI I) and vascular endothelial growth factor (VEGF) blood level measurements were performed in 34 children. Results: Children with headaches had higher BMI z-scores (0.2 vs. -1.14; p = 0.006). TC level was lower in patients with headaches (121.04 mg/dl vs. 146.87 mg/dl, p = 0.019). No differences in concentrations of TG, HDL or LDL were found. BDNF was significantly higher in the studied group (171.57 pg/ ml vs. 64.04 pg/ml, p = 0.012). The VEGF was higher in boys with headaches than in girls (368.27 pg/ml vs. 142.86 pg/ml, p = 0.011). There were no differences in levels of VEGF, sCD40L or PAI-1 between groups. Conclusions: Children with headaches have lower total cholesterol and higher BDNF levels than controls. No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls.

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Section: Discussionsupporting

confidence: 89%

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Sordyl

Kopyta

Sarecka-Hujar

et al. 2019

aoms

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“…Comorbidity with obesity has been reported in children and in adults with headaches (3,(23)(24)(25), but both of these conditions are widespread and conclusive results are difficult to obtain. In obese …”

Section: Discussionmentioning

confidence: 99%

“…Other associated conditions are epilepsy (10-15), asthma and allergic disorders (16), sleep disorders (17-21), celiac disease (CD) (22), and obesity (23)(24)(25).…”

Section: Discussionmentioning

confidence: 99%

Primary Headaches in Children: Clinical Findings and the Association with other Conditions

Pavone

Rizzo

Conti

et al. 2012

Int J Immunopathol Pharmacol

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The aim of the present study is to report on the frequency of some comorbidities in primary headaches in childhood. Two hundred and eighty children (175 males and 105 females; ratio 1.7:1), aged 4 to 14 years, affected by primary headaches were consecutively enrolled in this study. In direct interviews, parents and children gave information about the association of their headaches with different conditions including asthma and allergic disorders, convulsive episodes, sleep disorders and increased body weight, affections some time associated in the literature to headache as comorbidities . In addition, anxiety and depression, attention deficitlhyperactivity disorder, tics, learning disabilities and obsessive-compulsive disorders, using psycho-diagnostic scales were evaluated. Two hundred and eighty children matched for age, sex, race and socio-economic status; were used as controls. No significant association of primary headaches was found with asthma and allergic disorders, convulsive episodes, sleep disorders and increased body weight. Overall behavioral disorders were more common in children who experienced headache than in controls. A significant association of primary headache was found with anxiety and depression (p value <0.001), but not with the other psychiatric disorders. Primary headaches in children are not associated with most of the psychiatric and systemic conditions herein investigated. On the contrary, there was a significant association with anxiety and depression, as frequently reported in adults.Recurrent headaches are very widespread and disabling conditions in children. Although most cases follow a benign course, they cause substantial worry in parents and caregivers. The diagnosis of primary and secondary headache disorders is based upon the history of headaches, a careful physical and neurological examination, and in some cases, neurological investigations.Recurrent, episodic and paroxysmal attacks are suggestive of primary headache disorders, which have been subdivided into migraines, tension-type headaches (TTHs), cluster headaches, and other (uncommon) types in children. Migraines are further subdivided into migraines with and without auras, complicated migraines and migraine variants (1-3). Migraines have been estimated to affect nearly 75% of children under the age of 15 years and have been reported in 3.9% of children between the ages of 7 and 15 years, with a range from 1.7% in 7-yearold children to 5% in l5-year-old children (3-4).

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“…En este sentido, el primer estudio del que tengamos conocimiento que haya analizado esta relación en población pediátrica es el de Hershey y cols. (26), y específicamente en relación con el dolor de cabeza. En este trabajo se analizaron datos de 913 pacientes pertenecientes a varios centros en diferentes momentos temporales y los resultados mostraron que, en los pacientes obesos o que se encontraban en riesgo de tener sobrepeso en la visita inicial, los aumentos y reducciones en el Índice de Masa Corporal (IMC) estaban asociados con un incremento o disminución, respectivamente, de la frecuencia de los dolores de cabeza a los 3 y 6 meses.…”

Section: Factores De Riesgo Del Dolor Crónico Infantilunclassified

Psicología y dolor crónico infantil

Miró¹,

Vega²,

Solé³

et al. 2017

Rev. Soc. Esp. Dolor.

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Este es un archivo PDF de un manuscrito inédito que ha sido aceptado para su publicación en la Revista de la Sociedad Española del Dolor. Como un servicio a nuestros clientes estamos proporcionando esta primera versión del manuscrito en estado de prepublicación. El manuscrito será sometido a la corrección de estilo final, composición y revisión de la prueba resultante antes de que se publique en su forma final. Tenga en cuenta que durante el proceso de producción se pueden dar errores lo que podría afectar el contenido final. El copyright y todos los derechos legales que se aplican al artículo pertenecen a la Revista de la Sociedad Española de Dolor.

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Obesity in the Pediatric Headache Population: A Multicenter Study

Abstract: Obesity is associated with headache frequency and disability in the pediatric headache population. For children who are overweight, weight loss can contribute to a reduction in headaches over time. Clinicians should consider child weight status in providing care for pediatric headache.

Cited by 124 publications

References 19 publications

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Primary Headaches in Children: Clinical Findings and the Association with other Conditions

Psicología y dolor crónico infantil

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