Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Sordyl, Joanna; Kopyta, Ilona; Sarecka-Hujar, Beata; Francuz, Tomasz; Matusik, Paweł; Małecka-Tendera, Ewa

doi:10.5114/aoms.2018.73983

Cited by 5 publications

(8 citation statements)

References 42 publications

(41 reference statements)

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“…In Southern Thailand, dyslipidaemia, which is an independent modifiable risk factor for CVD [30][31], has been found to affect more than 50% of people [29]. Additionally, the prevalence of vitamin D deficiency (6.30 to 6.91%) and vitamin D insufficiency (43.74 to 43.80%) is highest when compared with other regions of Thailand [32][33].…”

Section: Introductionmentioning

confidence: 99%

The association between serum 25-hydroxyvitamin D concentrations and serum lipids in the Southern Thai population

Jeenduang

Sangkaew

2020

Arch Med Sci

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IntroductionDyslipidaemia is a major risk factor for cardiovascular diseases (CVD). Vitamin D deficiency has been found to be associated with CVD. However, the relationships between vitamin D and lipids are inconsistent. The aim of this study was to investigate the relationship between vitamin D status and serum lipids in Southern Thai subjects.Material and methodsA total of 726 healthy subjects in Southern Thailand were enrolled in the study. Serum 25-hydroxyvitamin D (25(OH)D), lipid profiles, fasting plasma glucose, anthropometric data, blood pressure, and body composition were measured. The relationship between serum 25(OH)D levels and biochemical data was evaluated by partial correlation and multiple linear regression analyses. The association of serum 25(OH)D levels with dyslipidaemia was analysed using multivariate regression analysis.ResultsSerum 25(OH)D levels were negatively correlated with body mass index (BMI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and body composition parameters after adjusting for age in women. Multiple linear regression analysis showed that TC and BMI were independent predictors for 25(OH)D concentrations in women. Multivariate logistic regression analysis showed that the odds ratio of hypertriglyceridaemia (OR 0.51; 95% CI: 0.32–0.80, p = 0.004) and reduced high-density lipoprotein cholesterol (HDL-C) (OR 0.43; 95% CI: 0.26–0.71, p = 0.001) were significantly lower in vitamin D sufficiency when compared with hypovitaminosis D in women.ConclusionsVitamin D sufficiency could reduce risk of hypertriglyceridaemia and reduced HDL-C, particularly in women, suggesting that vitamin D sufficiency may have beneficial effects on lipids and a decreased risk for CVD in Thai women.

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Section: Introductionmentioning

confidence: 99%

The association between serum 25-hydroxyvitamin D concentrations and serum lipids in the Southern Thai population

Jeenduang

Sangkaew

2020

Arch Med Sci

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“…Elevated lipid levels were observed in adults with idiopathic headaches, but there are only a few small clinical studies showing a relationship between disturbances in lipid levels and migraine in pediatric patients [ 14 , 22 , 58 , 59 , 60 , 61 ]. A significant positive correlation between the frequency and intensity of migraine and the levels of total cholesterol as well as low-density lipoprotein (LDL) cholesterol was observed in an Italian study.…”

Section: Resultsmentioning

confidence: 99%

“…According to the results of thee meta-analyses of over 1000 patients suffering from migraine, BDNF gene polymorphisms, rs6265 and rs2049046, are associated with common migraine in the Caucasian population; both data came from adult migraineurs [ 82 , 83 ]. Our preliminary data demonstrated higher levels of BDNF in children with headaches than in the controls [ 59 ]. Presumably, the elevated BDNF level may result from hypoxia, which induces its production.…”

Section: Resultsmentioning

confidence: 99%

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Headache in Children: Selected Factors of Vascular Changes Involved in Underlying Processes of Idiopathic Headaches

et al. 2020

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Headaches are common complaints in children. The International Classification of Headache Disorders, 3rd edition (beta version), defines more than 280 types of headaches. Primary headaches refer to independent conditions that cause pain and include migraine, tension-type headaches (TTH), and trigeminal autonomic cephalalgias (TACs). Several agents are involved in the pathogenesis of headaches. The factors associated with predisposition to atherosclerosis seem to be particularly important from the clinical point of view. The influence of obesity on the incidence of headaches has been well established. Moreover, idiopathic headaches, especially migraine, are thought to be one of the first signs of disorders in lipid metabolism and atherosclerosis. The risk of migraine increases with increasing obesity in children. Another factor that seems to be involved in both obesity and headaches is the adiponectin level. Recent data also suggest new potential risk factors for atherosclerosis and platelet aggregation such as brain-derived neurotrophic factor (BDNF), sCD40L (soluble CD40 ligand), serpin E1/PAI I (endothelial plasminogen activator inhibitor), and vascular endothelial growth factor (VEGF). However, their role is controversial because the results of clinical studies are often inconsistent. This review presents the current knowledge on the potential markers of atherosclerosis and platelet aggregation, which may be associated with primary headaches.

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“…Children were recruited at the Department of Pediatric Neurology (within two projects: 3PO5E 135 23, N 406 037 31/0986) and the Department of Pediatric Endocrinology of the Medical University of Silesia in Katowice (Poland) (within two projects: KNW-2-050/D/5/N, KNW-2-O75/D/6/K). Preliminary data were previously published as pilot studies [ 17 , 18 ].…”

Section: Methodsmentioning

confidence: 99%

Levels of Lipid Parameters in Children with Arterial Ischemic Stroke and Headache: Case-Control Study and Meta-Analysis

et al. 2021

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Background: Abnormalities in levels of lipid parameters are one of the main causes of cardiovascular and cerebrovascular disease in adults. There are limited data on the role of disturbances of lipid metabolism in the etiopathogenesis of arterial ischemic stroke (AIS) in children and the results provided are ambiguous. The aim of the study was to compare the levels of lipid parameters (total cholesterol [TC], triglycerides [TG], high-density lipoprotein [HDL] and low-density lipoprotein [LDL]) between children with AIS, children with headache and healthy children. In addition, we performed meta-analysis of available data on lipid parameters in young patients with AIS. Methods: We retrospectively analyzed 218 children hospitalized between 2002 and 2018 in the Upper-Silesian Child’s Health Center (n = 82 children with AIS, n = 45 children with headache, n = 91 healthy children) with available data on lipid levels, i.e., TC, TG, and HDL. The levels of LDL, non-HDL cholesterol, and a very-low density lipoprotein (VLDL) were calculated. The ratios of TC/HDL, TG/HDL and LDL/HDL were also assessed. Data between cases and controls were analyzed using STATISTICA 13.0 whereas meta-analysis was performed with RevMan version 5.4 software. Results: Children with headache were significantly older than children with AIS (p = 0.001). Ten percent of children with AIS had posterior stroke. The mean TC level was significantly higher in the AIS children than in controls or in children with headache. Mean TG and VLDL levels were significantly different between all groups (p < 0.001 each). The hypertriglyceridemia was more prevalent in AIS children than in children with headache (39% vs. 13%, OR = 4.16 95% CI 1.58–10.94, p = 0.004). Similarly, the frequency of dyslipidemia was higher in children with AIS compared to children with headache (38% vs. 22%, OR = 2.13 95% CI 0.93–4.89, p = 0.078). The meta-analysis was conducted based on data from 4 studies (3 studies published previously plus the results we obtained in the present case-control analysis) with total number of 236 young patients with AIS and 272 healthy controls. Significant Standard Mean Difference (SMD) was found in triglycerides level between young patients with AIS and controls (0.78 95%CI 0.30–1.26 p = 0.002). Conclusions: Lipid abnormalities, especially levels of triglycerides, seem to be of particular importance in children with AIS, as confirmed in meta-analysis. The results of the present study may be a significant contribution to the further research on the role of lipid metabolism disorders in the development of childhood stroke.

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Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Cited by 5 publications

References 42 publications

The association between serum 25-hydroxyvitamin D concentrations and serum lipids in the Southern Thai population

The association between serum 25-hydroxyvitamin D concentrations and serum lipids in the Southern Thai population

Headache in Children: Selected Factors of Vascular Changes Involved in Underlying Processes of Idiopathic Headaches

Levels of Lipid Parameters in Children with Arterial Ischemic Stroke and Headache: Case-Control Study and Meta-Analysis

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