Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission

Lighter, Jennifer; Phillips, Michael; Hochman, Sarah; Sterling, Stephanie; Johnson, Diane H.; François, Fritz; Stachel, Anna

doi:10.1093/cid/ciaa415

Cited by 1,131 publications

(1,195 citation statements)

References 6 publications

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“…novel data from a single center retrospective study confirm that obesity had a high frequency among patients admitted in intensive care for SarS-coV-2 requiring invasive mechanical ventilation and that disease severity increased with BMi (154). indeed, a very recent report on a large sample of patients younger than 60 years tested positive for coVid-19, correlated higher BMis values with increased probability for admission to critical care (155).…”

Section: Covid-19 and The Obesity Paradoxmentioning

confidence: 84%

Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)

et al. 2020

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Section: Covid-19 and The Obesity Paradoxmentioning

confidence: 84%

Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)

et al. 2020

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“…Besides the findings in our study, some other factors might also contribute to the mortality of COVID-19 patients, among which obesity would be a potential candidate. A recent study in the New York area showed that 41.7% of the patients were obese, and an increasing number of reports have linked obesity to more severe COVID-19 illness (35)(36)(37).…”

Section: Resultsmentioning

confidence: 99%

Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study

et al. 2020

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OBJECTIVEDiabetes is common in COVID-19 patients and associated with unfavorable outcomes. We aimed to describe the characteristics and outcomes and to analyze the risk factors for in-hospital mortality of COVID-19 patients with diabetes. RESEARCH DESIGN AND METHODSThis two-center retrospective study was performed at two tertiary hospitals in Wuhan, China. Confirmed COVID-19 patients with diabetes (N 5 153) who were discharged or died from 1 January 2020 to 8 March 2020 were identified. One sexand age-matched COVID-19 patient without diabetes was randomly selected for each patient with diabetes. Demographic, clinical, and laboratory data were abstracted. Cox proportional hazards regression analyses were performed to identify the risk factors associated with the mortality in these patients. RESULTSOf 1,561 COVID-19 patients, 153 (9.8%) had diabetes, with a median age of 64.0 (interquartile range 56.0-72.0) years. A higher proportion of intensive care unit admission (17.6% vs. 7.8%, P 5 0.01) and more fatal cases (20.3% vs. 10.5%, P 5 0.017) were identified in COVID-19 patients with diabetes than in the matched patients. Multivariable Cox regression analyses of these 306 patients showed that hypertension (hazard ratio [HR] 2.50, 95% CI 1.30-4.78), cardiovascular disease (HR 2.24, 95% CI 1.19-4.23), and chronic pulmonary disease (HR 2.51, 95% CI 1.07-5.90) were independently associated with in-hospital death. Diabetes (HR 1.58, 95% CI 0.84-2.99) was not statistically significantly associated with in-hospital death after adjustment. Among patients with diabetes, nonsurvivors were older (76.0 vs. 63.0 years), most were male (71.0% vs. 29.0%), and were more likely to have underlying hypertension (83.9% vs. 50.0%) and cardiovascular disease (45.2% vs. 14.8%) (all P values <0.05). Age ‡70 years (HR 2.39, 95% CI 1.03-5.56) and hypertension (HR 3.10, 95% CI 1.14-8.44) were independent risk factors for in-hospital death of patients with diabetes. CONCLUSIONSCOVID-19 patients with diabetes had worse outcomes compared with the sex-and age-matched patients without diabetes. Older age and comorbid hypertension independently contributed to in-hospital death of patients with diabetes.

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“…Once BMI or body fat was adjusted for, inflammatory markers were no longer associated with incident COVID-19. This suggests proinflammatory markers, arising from increased adipose deposition, are probably acting as a marker for body fat which seems to be an adverse risk factor for severe COVID-19 [27][28][29][30] .…”

Section: Covid-19 Infection Used Alongside Other Public Health Intermentioning

confidence: 99%

Modifiable and non-modifiable risk factors for COVID-19: results from UK Biobank

Celis‐Morales

Gray³

et al. 2020

Preprint

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Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission

Cited by 1,131 publications

References 6 publications

Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)

Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)

Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study

Modifiable and non-modifiable risk factors for COVID-19: results from UK Biobank

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