Obesity in Childhood

Abstract

Several hundred obese children have been referred to us as having Fr\l=o"\hlich's syndrome, or dystrophia adiposogenitalis. These patients were presumed to have pituitary disease or a combination of pituitary with thyroid involvement. Approximately 80 of this number1 have been studied thoroughly from the point of view of physical development (sexual and mensurational) (fundi and visual fields), and complete laboratory studies were made, including roentgenographic examination of the head (sella turcica), wrist and knee, and basal metabolism, blood cholesterol and sugar tolerance tests. In addition, we have used a roent-Downloaded From: http://archpedi.jamanetwork.com/ by a University of California -San Diego User on 06/09/2015

Experimental Studies on the Hypothalamic Control of the Female Gonadal Function

“…Furthermore,precocious puberty due to the hypothalamic injury has been described by Dorif and Shapiro(1937), Driggs andS patz(1939), Gross(1940)and Bronstein et al(1942)and the injured area of these cases situated in the posterior-ventral portion of the tuber cinereum or the mammillary body.Many cases which are considered to be ascribable to the increase of the intracranial pressure have also been reported by Dorff and Shapiro(1937).…”