Obesity, genetics and the skin

Millington, G. W. M.

doi:10.1111/ced.12024

Cited by 12 publications

(34 citation statements)

References 29 publications

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“…The association between monogenic obesity syndromes, such as Prader–Willy, McCune–Albright, and fragile X syndromes, and skin pathology is beyond the scope of this review. Hence, the readership is referred to the work of Millington for a detailed overview ( 17 ). For deductive purposes, we propose the following classification of specific skin changes related to obesity.…”

Section: Specific Skin Involvement In Obesitymentioning

confidence: 99%

The Link Between Obesity and the Skin

2022

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Obesity as a multi-organ disease that affects the entire human organism. Notably, the skin is no exclusion from this postulate. Skin changes in obese patients have been widely studied with regards to mechanical friction, skin infections, and skin hypertrophic conditions, such as acanthosis nigricans and, most commonly, fibromas (skin tags). Almost 60–70% of obese patients present with a variety of skin changes. Herein, we discuss our own experience and review the complex skin changes in obesity. The role of metabolic syndrome and obesity are responsible for the epidemiological prevalence and are involved in the pathogenesis of chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, and skin malignancies. Here, we comment on the role of nutritional interventions in these patients as it has been proven that low-calorie diet and weight loss is related to improvement of inflammatory skin diseases. The readership of this paper will receive up-to-date overview on the connection between obesity and the skin that is of a practical importance to any clinician working in the field.

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Section: Specific Skin Involvement In Obesitymentioning

confidence: 99%

The Link Between Obesity and the Skin

2022

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“…Some cutaneous features and skin diseases are associated with genetically induced childhood obesity. Generalised hypopigmentation and acanthosis nigricans are seen in Prader-Willi syndrome, regional hyperpigmentation in fragile X syndrome, atomic eczema in MOMES syndrome, hypohidrosis, nipple hypoplasia in ulnar-mammary syndrome and obesity syndromes which are commonly associated with disorders of pigmentation (25).…”

Section: Dermatological Systemmentioning

confidence: 99%

The Comorbidities of Childhood Obesity

Ajari¹,

Ademusire²,

Babatunde³

2021

Preprint

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Childhood obesity is a preventable multi-systemic disorder, defined as the body mass index of a child being at or above the 95th percentile, has become an epidemic. In 2019, about 38 million under-five children and over 300 million individuals aged 5-19 were reported to be overweight or obese. In this narrative review, we showed evidences, from existing literature, of the affectation of various body systems by childhood obesity. Co-morbid disorders associated with childhood obesity in the cardiovascular, nervous, dermatological, respiratory, endocrine, reproductive, musculoskeletal, gastrointestinal, and renal systems, and its effects on mental health are discussed. Since obesity ultimately reduces the quality of life of children and is a leading cause of preventable deaths of children globally, effective research, policy and community-based project interventions, aimed at the prevention of obesity and the treatment of its co-morbid disorders, should be taken by all appropriate stakeholders.

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“…In predisposed individuals, obesity is a triggering factor for diabetes (56). Dermatoses act as specific markers of diabetes (necrobiosis lipoidica, disseminated annular granuloma, diabetic bullous disease, scleredema, acanthosis nigricans, eruptive xanthoma, diabetic dermopathy); as non-specific markers of diabetes (acrochordons, generalized itching, palmar/facial and nail erythema, pigmentary purpura); and as markers of complications, comorbidities, infections and drug reactions (35).…”

Section: Diabetic Dermopathymentioning

confidence: 99%

Dermatological aspects influencing the practice of physical activities by obese individuals

Titski

Leite

2015

Fisioter. mov.

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Objective : The aim of this study was to perform a systematic review of the major skin diseases affecting obese individuals and their influence on physical activity. Methods : Relevant articles were identified by systematically searching PubMed from 2000 to 2014, using the descriptors "skin diseases" and "obesity", "skin disease" and "obesity", "skin diseases" and "physical activity", "skin disease" and "physical activity". The PEDro Scale (in Brazilian Portuguese) was used to rate the methodological quality of the studies. Results : A total of 320 articles were examined in the first phase. In the end, 11 articles met the proposed criteria and were included for analysis in the systematic review. We investigated cutaneous manifestations of diseases and classified them according to their effects under 5 categories: metabolic (n = 10), aesthetic (n = 7), inflammatory (n = 6), mechanical (n = 5) and infectious (n = 3). The most frequent dermatoses among obese were acanthosis nigricans, acrochordon (skin tags), stretch marks, plantar keratodermia, intertrigo, bacterial and fungal infections. Acanthosis nigricans was found to be the most important metabolic implication of obesity. Conclusion : Although neglected, skin lesions are common in obesity and have implications for physical activity because they cause pain, discomfort, friction, infection, inflammation, embarrassment, limitation or difficulty of movement. Strategies to promote skin health may result in a better integration of physical activity into routine therapy and improve the quality of life of obese individuals.

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Obesity, genetics and the skin

Cited by 12 publications

References 29 publications

The Link Between Obesity and the Skin

The Link Between Obesity and the Skin

The Comorbidities of Childhood Obesity

Dermatological aspects influencing the practice of physical activities by obese individuals

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