Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer

Déchaud, H.; Anahory, T.; Reyftmann, Lionel; Loup, V.; Hamamah, S.; Hédon, B.

doi:10.1016/j.ejogrb.2005.12.009

Cited by 148 publications

(135 citation statements)

References 35 publications

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“…The quality of embryos is frequently utilized to predict implantation rates and subsequent clinical pregnancy rates. Similar to prior studies [15,16,20, 21], we did not observe a significant difference in embryo morphology at the cleavage stage. However, we did observe a statistically significant decline in blastocyst formation rate in patients who were overweight/obese versus normal-weight controls (43.6 versus 57.2 %, respectively).…”

Section: Discussionsupporting

confidence: 91%

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Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

Comstock

Kim

Behr

et al. 2015

J Assist Reprod Genet

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Purpose The aim of this study is to investigate the effect of female BMI and metabolic dysfunction on blastocyst formation rate. Methods This was a retrospective cohort study that was performed in an academic center for reproductive medicine. Patients who were normal weight, overweight with metabolic dysfunction, or obese who had ≥6 oocytes retrieved in a fresh IVF cycle were included in the study. The blastocyst formation rate was calculated from the number of ≥5 cell embryos on day 3 observed in culture until day 5 or day 6. Only good quality blastocysts were included in the calculation as defined by a morphologic grade of 3BB or better. Results The blastocyst formation rate was significantly better in the normal-weight controls versus overweight/obese patients (57.2 versus 43.6 %, p<0.007). There was no difference in blastocyst formation between the patients with a BMI 25-29.9 kg/m 2 with metabolic dysfunction and those with a BMI ≥30 kg/m 2 . Conclusion The maternal metabolic environment has a significant impact on embryo quality as measured by blastocyst formation. A decreased blastocyst formation rate is likely a significant contributor to poorer reproductive outcomes in overweight and obese women with infertility.

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Section: Discussionsupporting

confidence: 91%

“…Studies have shown lower clinical pregnancy rates, higher miscarriage rates, and decreased live birth rates in women with an elevated body mass index [9,[12][13][14]. Other studies, however, have shown no difference in live birth rates when comparing IVF outcomes between normal-weight and obese patients [7,8,15].…”

Section: Introductionmentioning

confidence: 99%

Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

Comstock

Kim

Behr

et al. 2015

J Assist Reprod Genet

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“…Inconsistent findings have been reported with respect to the effect of obesity upon embryo quality (Carrell et al 2001, Fedorcsak et al 2004, Spandorfer et al 2004, Dechaud et al 2006, Metwally et al 2007a. In a prospective study of 247 women undergoing IVF, it was observed that obese (BMI O30 kg/m 2 ) women had significantly poorer quality embryos compared with women with BMI 20-30 kg/m 2 (Carrell et al 2001).…”

Section: Obesity and The Embryomentioning

confidence: 95%

“…Some authors have identified a reduction in implantation rates among the obese women (Loveland et al 2001, Bellver et al 2010, whereas others have not demonstrated a weightrelated reduction (Fedorcsak et al 2004, Dechaud et al 2006, Dokras et al 2006). An unfavourable intrauterine milieu and impaired endometrial receptivity are plausible loci for the effect of obesity upon subfecundity; however, the evidence is inconsistent and obese women tend to suffer non-recurrent spontaneous pregnancy loss (Lashen et al 2004, Bellver et al 2006.…”

Section: Obesity and The Endometriummentioning

confidence: 99%

The adverse effects of obesity on conception and implantation

Brewer¹,

Balen²

2010

Reproduction

410

277

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Whilst many multiparous women are obese (body mass index O30 kg/m 2 ), obesity has been associated with impaired fecundity; however, the mechanism which links obesity to reduced fertility remains to be fully elucidated. Obese women, particularly those with central obesity, are less likely to conceive per cycle. Obese women suffer perturbations to the hypothalamic-pituitary-ovarian axis, menstrual cycle disturbance and are up to three times more likely to suffer oligo-/anovulation. A fine hormonal balance regulates follicular development and oocyte maturation, and it has been observed that obesity can alter the hormonal milieu. Leptin, a hormone produced by adipocytes, is elevated in obese women, and raised leptin has been associated with impaired fecundity. Obesity impairs ovulation but has also been observed to detrimentally affect endometrial development and implantation. The expression of polycystic ovary syndrome (PCOS) is regulated, in part, by weight, and so obese women with PCOS often have a more severe phenotype and experience more subfertility. Obesity also impairs the response of women to assisted conception treatments. Weight loss through lifestyle modification or bariatric surgery has been demonstrated to restore menstrual cyclicity and ovulation and improve the likelihood of conception. In this article, we will discuss the effect of obesity upon key reproductive mechanisms and its relation to fertility treatments.

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“…(6) demonstrated that implantation rates and pregnancy rates decrease with increasing BMI. In 2006, Dechaud et al (7) showed that obesity does not have any adverse impact on IVF, and Metwally et al (8) showed that obesity does not affect oocyte quality or clinical pregnancy rates in IVF/intracytoplasmic sperm injection (ICSI) cycles in 2007. Because weight loss in PCOS has positive effects on hormonal, metabolic, and clinical parameters, recent studies have focused on the effect of BMI during IVF cycles in PCOS patients.…”

Section: Introductionmentioning

confidence: 99%

Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Kalem

Sarı

et al. 2016

J Turkish German Gynecol Assoc

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Results:Variations in cycle variables with BMI and age showed that IVF cycles were negatively affected by increases in obesity and age. Clinical pregnancy rates were found to be lower in the obese group than in the other groups, particularly in the age group above 35 years; however, this difference could not be proven statistically. Conclusion:The present study evaluated obesity and clinical pregnancy rates in IVF cycles in PCOS patients according to age groups, and particularly in the obese group, the clinical pregnancy rates were observed to be lower in the age group ≥35 years than in the other BMI groups; however, this difference was found to be statistically insignificant. (J Turk Ger Gynecol Assoc 2016; 17: 83-90) Keywords: PCOS, body mass index, age, IVF outcome Received: 31 December, 2015 Accepted: 8 March, 2016 Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome Bailey et al. (12) investigated the effect of BMI on the characteristics and outcomes of IVF cycles in PCOS and found lower clinical pregnancy rates in an obese PCOS group than in a lean group and a lower rate of ovarian hyperstimulation syndrome (OHSS) in the obese group. A woman's age is also an important factor in IVF success (13,14). The IVF success rate reduces with increasing age in PCOS, as in all infertile patient groups (15, 16). The literature contains a very limited number of studies that investigate age and BMI together. Heijnen et al. (17) reported that although BMI has a significant and negative effect on female fertility, this effect gradually decreases as women approach their mid-thirties and also in younger women receiving IVF. Above the age of 36 years, on the other hand, the effect of BMI on fertility becomes minimal. PCOS patients were not included in this study. The study by Metwally et al. (8) that investigated 426 IVF/ICSI cycles did not exclude PCOS patients and reported that although obesity does not affect oocyte quality, there is a reduction in embryo quality in patients under the age of 35 years. The hypothesis of the present study assumed that the effect of BMI on the IVF cycles of PCOS patients may vary with age. The present study aimed to investigate age-related variations in the effect of BMI on IVF outcomes. Material and MethodsThis was a cohort study conducted by retrospectively investigating the IVF cycles of 653 PCOS patients under the age of 40 years, who were diagnosed based on the Rotterdam criteria in Gürgan IVF clinic between 2005 and 2015. The study protocol was approved by the local ethics committee, and all patients included in the study provided informed consent. The patients were diagnosed with PCOS in accordance with the diagnostic criteria of the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam Consensus Meeting 2003 (18). Based on this set of criteria, two of the following three criteria are necessary for confirming a diagnosis: -Anovulation or Oligoovulation -Biochemical or Clinical Hyperandr...

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Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer

Cited by 148 publications

References 35 publications

Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

The adverse effects of obesity on conception and implantation

Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

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