Obesity as a risk factor for diseases of the digestive system

Andreev, D. N.; Николаевич, Андреев Дмитрий; Kucheryavy, Yu.A.; Александрович, Кучерявый Юрий

doi:10.26442/00403660.2021.08.200983

Cited by 13 publications

(2 citation statements)

References 67 publications

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“…Отягощающим фактором в этом процессе является ожирение. При ожирении возникающая гипертрофия и гиперплазия адипоцитов приводит к изменению профиля продукции адипокинов (снижение адипонектина, повышение лептина), повышению продукции провоспалительных цитокинов (интерлейкин-1, 6, 8, ФНО-α), С-реактивного белка, свободных жирных кислот, а также АФК (супероксидные радикалы, H2O2) [22]. Эти вещества индуцируют развитие хронического медленно прогрессирующего воспаления, окислительного стресса и приводят к прогрессированию канцерогенеза.…”

Section: роль гэрб и ожирения в канцерогенезе посредством окислительн...unclassified

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Bulgakova,

Shrayner,

Khavkin

et al. 2024

ECG

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Currently, special attention is drawn to the phenomenon of comorbidity of chronic non-infectious diseases. The emergence of comorbidity is facilitated by the high incidence of coexisting diseases. One such combination is GERD and metabolic syndrome (MS). GERD and MS are multifactorial diseases, the pathogenesis of which is intertwined and mutually aggravates each other. Every year throughout the world and the Russian Federation, there is a clear trend towards an increase in the incidence of pathology of the upper gastrointestinal tract, namely gastroesophageal reflux disease (GERD). The prevalence of obesity in Russia over 40 years of observation has increased 4 times among men and 1.5 times among women. Despite the high incidence, to date there is no diagnosis of “metabolic syndrome” (MS) in ICD-10. MS is coded based on its constituent pathologies (obesity, dyslipidemia, insulin resistance, arterial hypertension). Treatment of this comorbid pathology requires a multidisciplinary approach, thereby placing a high burden on the healthcare system. This article displays the features of the pathogenesis and clinical picture of GERD, as well as the combination of this pathology with the components of MS.

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Section: роль гэрб и ожирения в канцерогенезе посредством окислительн...unclassified

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

Bulgakova,

Shrayner,

Khavkin

et al. 2024

ECG

View full text Add to dashboard Cite

show abstract

“…В настоящее время особое внимание исследователей уделяется изучению генов, ответственных за синтез ферментов, причастных к развитию ОААП и его осложнений [6][7][8][9][10][11][12]. Применение генетического тестирования позволило расширить представления о роли предрасположенности в патогенезе заболевания [13,14].…”

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The risk of severe acute pancreatitis depending on the genetic predisposition and diet

Samgina,

Kochetova

2024

jour

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The aim of the study: to determine the influence of genetic predisposition and diet on the risk of severe acute pancreatitis (АР). Materials and methods. The results of diagnostics and treatment of 547 patients with acute pancreatitis were analyzed, 97 of them had a severe АР. Patients' blood DNA samples were used as research material. Detailed questionnaire on nutrition was carried out, the qualitative and quantitative composition of the food consumed was assessed. Genomic DNA was isolated using the standard PCE method. Genotyping was performed on a MALDI-TOF MassARRAY-4 analyzer. The role of the following polymorphic variants was studied: SPINK1 C>T (rs6580502), PRSS1 C>T (rs10273639), CFTR A>G (rs213950), TNF -308 G>A (rs1800629), IL1B A>G (rs16944), IL5 A>G (rs2069812), IL6 G>C (rs1800795), IL10 T>C (rs1800896), CETP G>A (rs708272) and LPL T>G (rs320). Statistical analysis was performed using SNPStats and Statistica 10.0 software. Results. In our study, we found that carriers of A/A rs2069812 IL5, G/G-G/C rs1800795 IL6 and T/T rs320 LPL genotypes increased the risk of severe acute pancreatitis. Alcohol abuse increases the risk of severe disease in carriers of T/T SPINK1 (rs6580502) and A/A CFTR (rs213950) genotypes. Constant exposure to alimentary risk factor manifested by increased consumption of fatty foods increases the risk in carriers of G/A-A/A rs 16944 IL1B, reduced protein and carbohydrate intake with food - in carriers of G/A-A/A rs2069812 IL5, carbohydrate - in carriers of G/A-A/A rs708272 CETP. Conclusion. Predictive diagnostics plays an important role in the prevention of severe acute pancreatitis, eliminating the effects of risk factors in carriers of genotypes associated with a severe course of the disease will make it possible to achieve positive success in the prevention of AP, to reduce the frequency of complications and the development of its severe course, to reduce mortality.

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Hepatocardial relationships in non-alcoholic fatty liver disease: issues of epidemiology, diagnosis, prognosis

Savzikhanova,

Subkhangulova,

Khazova

2024

Kazan Med J

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World statistics indicate a steady increase in the prevalence of non-alcoholic fatty liver disease, which correlates with the pandemics of obesity and diabetes, which are quite common in Russia. The commonality of cardiometabolic risk factors, the high global prevalence of non-alcoholic fatty liver disease and atherosclerotic cardiovascular diseases generates the interest of researchers in studying hepatocardial relationships. Currently, non-alcoholic fatty liver disease is positioned as a hepatic manifestation of a multisystem disorder, heterogeneous in underlying causes, manifestations, course and outcomes. The purpose of this review was to analyze hepatocardial relationships based on publications. 76 sources on the epidemiology of non-alcoholic fatty liver disease, published from 2011–2023 in journals indexed in Pubmed and eLibrary, were analyzed. Age and gender aspects of the development of non-alcoholic fatty liver disease were considered. The pathogenetic mechanisms of hepatocardial relationships, which were closely related to systemic inflammation, insulin resistance, metabolic syndrome and its components, were highlighted. The criteria and methods for diagnosing non-alcoholic fatty liver disease and metabolic-associated liver disease were outlined. Recent studies demonstrated the presence of hepatocardial connections, characterized by an increased risk of developing atherosclerosis, cardiomyopathy and rhythm disturbances, changes in the structural and functional parameters and geometry of the heart, as well as diastolic dysfunction, which may precede and/or contribute to the development of chronic heart failure in patients with non-alcoholic fatty liver disease. The article presents data on non-alcoholic fatty liver disease as a new factor associated with the development of adverse cardiovascular events to a greater extent than the outcome of liver diseases themselves, which confirms the need for primary and secondary prevention of cardiovascular diseases in this cohort of patients.

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Obesity as a risk factor for diseases of the digestive system

Cited by 13 publications

References 67 publications

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

The relationship between gastroesophageal pathogenic reflux and metabolic syndrome

The risk of severe acute pancreatitis depending on the genetic predisposition and diet

Hepatocardial relationships in non-alcoholic fatty liver disease: issues of epidemiology, diagnosis, prognosis

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