Obesity and Risk of Cancer in Postmenopausal Korean Women

Song, Yun-Mi; Sung, Joohon; Ha, Mina

doi:10.1200/jco.2007.15.7867

Cited by 99 publications

(82 citation statements)

References 39 publications

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“…A significantly higher number of patients were postmenopausal (61.96%) as compared to controls (30.44%). In previous reports, an increased risk of breast and endometrial cancers has been reported in postmenopausal obese women in the Western (Reeves et al, 2007), Korean (Song et al, 2008), as well as Asian population (Kuriyama et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Association of −2549 Insertion/Deletion Polymorphism of Vascular Endothelial Growth Factor with Breast Cancer in North Indian Patients

Kapahi

Manjari²,

Uppal³

et al. 2013

Genetic Testing and Molecular Biomarkers

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Section: Discussionmentioning

confidence: 99%

Association of −2549 Insertion/Deletion Polymorphism of Vascular Endothelial Growth Factor with Breast Cancer in North Indian Patients

Kapahi

Manjari²,

Uppal³

et al. 2013

Genetic Testing and Molecular Biomarkers

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“…Now, 2 cohort studies have been reported from Asia. Oh et al 8 reported that a BMI of 25.0-29.9 kg/m 2 was associated with a 54% higher NHL risk than a BMI of 18.5-22.9 kg/m 2 with marginal significance among Korean men, whereas Song et al 11 reported no association between BMI and ML risk among postmenopausal Korean women.…”

mentioning

confidence: 93%

“…[1][2][3][4][5][6][7][8][9][10][11] Moreover, most of these studies were conducted in non-Asian populations. Recently, the International Lymphoma Epidemiology Consortium (InterLymph) reported a large pooled analysis of 18 case-control studies conducted at various centers, including ours, to evaluate the impact of recent obesity on NHL risk, with the results suggesting no significant association between NHL and obesity.…”

mentioning

confidence: 99%

Association between obesity and the risk of malignant lymphoma in Japanese: a case–control study

Kanda

Matsuo

Suzuki

et al. 2010

Intl Journal of Cancer

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Although marked differences in anthropometric characteristics and malignant lymphoma (ML) incidence suggest that the association between obesity and ML risk in Asian and non-Asian populations may differ, few studies have investigated this association in Asian populations. Here, we conducted a sex-and age-matched case-control study in a Japanese population using 782 cases and 3,910 noncancer controls in the hospital-based Epidemiological Research Program at Aichi Cancer Center Hospital. Odds ratios (ORs) and 95% confidence intervals (CIs) for anthropometric characteristics were estimated using a conditional logistic regression model that incorporated smoking and alcohol intake. Recent body weight and body mass index (BMI) showed marginally significant association with ML risk (ORs [95% CIs] per 5-unit increase in recent weight and BMI; 1.04 [0.99-1.09] and 1.11 [0.98-1.27], respectively). On the other hand, weight and BMI in early adulthood exhibited a strong association with ML risk (ORs [95% CIs] per 5-unit increase in early adulthood weight and BMI; 1.11 [1.05-1.18] and 1.33 [1.13-1.55], respectively). Further, in women, a BMI of 25.0-29.9 kg/m 2 , defined as obesity in Asian populations, during early adulthood was significantly associated with ML risk compared to the normal range of 18.5-22.9 kg/m 2 . By histological ML subtype, the point estimates of ORs for obesity relative to normal weight in early adulthood were over unity for nonHodgkin lymphoma (NHL) as a whole and significant for diffuse large B-cell lymphoma (DLBCL). In conclusion, our study in Japanese subjects suggested that early adulthood obesity is associated with the risk of NHL, particularly DLBCL.Although the association between obesity and the risk of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) has been investigated in a number of case-control and cohort studies, results have been inconsistent. 1-11 Moreover, most of these studies were conducted in non-Asian populations. Recently, the International Lymphoma Epidemiology Consortium (InterLymph) reported a large pooled analysis of 18 case-control studies conducted at various centers, including ours, to evaluate the impact of recent obesity on NHL risk, with the results suggesting no significant association between NHL and obesity. 1 In contrast, Maskarinec et al. 2 reported that body weight and body mass index (BMI) at age 21 were stronger predictors of NHL risk than baseline anthropometric characteristics, suggesting that weight during early adulthood may be a better indicator of NHL risk than weight at an older age. Further, increase in various cytokines among obese people has been proposed as a mechanism underlying the development of malignant lymphoma (ML); bioavailable insulin-like growth factor-1 (IGF-1) and insulin play a role in promoting cellular proliferation and inhibiting apoptosis, 12-14 whereas leptin is considered to be involved in lymphomagenesis via inflammatory pathways. [15][16][17][18][19] Because Asian populations generally have a low BMI but higher

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“…After full-text review of the remaining 31 studies, two studies were excluded because one study did not report RR with the corresponding 95% CI and the other study did not provide sufficient data to calculate them. Thus, 14 (7,(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47) cohort studies and 15 (19,(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61) case-control studies were included in this meta-analysis.…”

Section: Literature Searchmentioning

confidence: 99%

Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta‐analysis of observational studies

Gan

et al. 2016

Obesity

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Objective: Epidemiological studies have repeatedly investigated the association between excess body weight and the risk of biliary tract cancer with inconsistent results. The objective of this study was to quantitatively assess the associations between overweight and obesity and the risk of biliary tract cancer. Methods: A comprehensive search of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases up to August 2015 was conducted, and the reference lists of retrieved articles for additional relevant studies were manually searched. Results: Fourteen prospective cohort studies and 15 case-control studies were included in this metaanalysis. These studies included 11,448,397 participants (6,733 patients with gallbladder cancer [GBC] and 5,798 patients with extrahepatic bile duct cancer [EBDC]) with follow-up durations ranging from 5 to 23 years. Among overweight adults, the pooled RR was 1.17 (95% CI, 1.07-1.28) for GBC and 1.26 (95% CI, 1.14-1.39) for EBDC, and among people with obesity, the pooled RR was 1.62 (95% CI, 1.49-1.75) for GBC and 1.48 (95% CI, 1.21-1.81) for EBDC. Visual inspection of the funnel plots and the Begg's and the Egger's tests did not show enough evidence of publication bias. Conclusions: Integrated evidence from this meta-analysis suggests that excess body weight is associated with a significantly increased risk of GBC and EBDC.

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Obesity and Risk of Cancer in Postmenopausal Korean Women

Abstract: Although variations exist between the individual cancer sites, obesity was associated with an overall increased risk of cancer in postmenopausal Korean women. To reduce the risk of cancer, active strategies to prevent obesity should be implemented in postmenopausal women.

Cited by 99 publications

References 39 publications

Association of −2549 Insertion/Deletion Polymorphism of Vascular Endothelial Growth Factor with Breast Cancer in North Indian Patients

Association of −2549 Insertion/Deletion Polymorphism of Vascular Endothelial Growth Factor with Breast Cancer in North Indian Patients

Association between obesity and the risk of malignant lymphoma in Japanese: a case–control study

Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta‐analysis of observational studies

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