2020
DOI: 10.4103/jfmpc.jfmpc_283_20
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Obesity and periodontal disease: A review

Abstract: Periodontal diseases usually refer to inflammatory disorders that are caused by pathogenic bacteria in the subgingival biofilm in association with impaired host immune response and connective tissue breakdown. The bacterial challenge exacerbates the cytokine production by the gingival epithelium, resulting in an uncontrolled inflammation that leads to tooth loss in adults from different populations. The prevalence of these diseases increases with aging, longer retention of teeth, and increased incidence of obe… Show more

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Cited by 14 publications
(13 citation statements)
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“…The prevalence of chronic diseases (e.g., hypertension, diabetes mellitus, hypertriglyceridemia, and hypercholesteremia) is continuously rising in Korea [ 37 ]. The association between periodontal and systemic diseases has been observed in many previous studies [ 38 , 39 , 40 , 41 ], and hence, the importance of comprehensively managing systemic and periodontal diseases is growing. In particular, factors such as diabetes increase the risk for periodontal diseases and may exacerbate their severity [ 42 , 43 ].…”
Section: Discussionmentioning
confidence: 97%
“…The prevalence of chronic diseases (e.g., hypertension, diabetes mellitus, hypertriglyceridemia, and hypercholesteremia) is continuously rising in Korea [ 37 ]. The association between periodontal and systemic diseases has been observed in many previous studies [ 38 , 39 , 40 , 41 ], and hence, the importance of comprehensively managing systemic and periodontal diseases is growing. In particular, factors such as diabetes increase the risk for periodontal diseases and may exacerbate their severity [ 42 , 43 ].…”
Section: Discussionmentioning
confidence: 97%
“…Periodontal diseases are widely distributed globally and act as an independent risk factor for many systemic diseases or exacerbate the existing conditions like diabetes mellitus, preterm low birth weight babies, cardiovascular diseases, respiratory diseases, metabolic syndrome, obesity, Alzheimer's disease and rheumatoid arthritis. [ 15 16 17 ] Microorganisms or their products from the oral cavity may reach into the systemic circulation and exert their effects directly or indirectly by releasing the inflammatory mediators on the pathogenesis of these systemic diseases. Herpes virus from the oral cavity may also access the systemic circulation and is associated with systemic diseases.…”
Section: Discussionmentioning
confidence: 99%
“…Life events and general health conditions can affect the bone metabolism ( Feres et al., 2016 ). For instance, obesity and hypertension have an impact on the oral microbial composition and regulate alveolar bone metabolism ( Del Pinto et al., 2020 ; Khan et al., 2020 ). Smoking, diabetes mellitus (DM), and estrogen deficiency are associated with systemic bone loss, including osteoporosis and alveolar bone resorption ( Weitzmann and Pacifici, 2006 ; Straka et al., 2015 ; Wang X. et al., 2020 ).…”
Section: Factors That Affect Oral Microbiota-mediated Alveolar Bone Metabolismmentioning
confidence: 99%