Obesity and lipid metabolism disorders determine the risk for development of long COVID syndrome: a cross-sectional study from 50,402 COVID-19 patients

Loosen, Sven H.; Jensen, Björn‐Erik Ole; Tanislav, Christian; Luedde, Tom; Roderburg, Christoph; Kostev, Karel

doi:10.1007/s15010-022-01784-0

Cited by 33 publications

(24 citation statements)

References 18 publications

(24 reference statements)

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“…In a study by Sykes et al, higher BMI was associated with muscle pain and fatigue [42]. The relationship between higher BMI and greater post-viral symptoms has also been demonstrated by other researchers [55,56]. It is worth noting that obesity is a strong risk factor for the development of a number of comorbidities that are associated with increased morbidity and mortality.…”

Section: Discussionmentioning

confidence: 77%

Searching for Factors Influencing the Severity of the Symptoms of Long COVID

Mińko

Turoń-Skrzypińska

Rył

et al. 2022

IJERPH

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COVID-19 is a highly contagious respiratory disease. Infection with the virus can occur with differing symptom severity, from mild and moderate to severe cases, but the long-term consequences of infection have not been fully identified or studied. Long COVID is defined as occurring in individuals with a history of probable or confirmed SARS-CoV-2 infection, and symptoms persisting for at least two months within three months of onset that cannot be explained by an alternative diagnosis. The purpose of this study was to look for factors that influence the type and severity of Long COVID symptoms. In total, 932 individuals with a history of COVID-19 were qualified for the study using an original questionnaire based on the COVID-19 Yorkshire Rehab Screen (C19-YRS) questionnaire. Older adults were more likely to report problems with mobility (p < 0.001) and in performing daily activities (p = 0.014). Those with a higher BMI showed significantly more symptoms such as dyspnea at rest (p < 0.001) and on exertion (p < 0.001), feelings of chronic fatigue (p = 0.023), problems with mobility (p < 0.001), and in performing daily activities (p = 0.002). The data show that those with Long COVID should receive multidisciplinary help including additional medical and psychological support. Particular attention should be paid to elderly and obese persons, who should be included in rehabilitation programs after COVID-19 in the first place.

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Section: Discussionmentioning

confidence: 77%

Searching for Factors Influencing the Severity of the Symptoms of Long COVID

Mińko

Turoń-Skrzypińska

Rył

et al. 2022

IJERPH

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“…Now emerging evidence supports the notion that these conditions also predispose to Long Covid (PASC). For example, lipid metabolism disorders and obesity were found to be age-independent risk factors for the development of PASC, as shown in a retrospective study involving more than 50.000 patients with a confirmed diagnosis of Covid-19 treated by general practitioners in Germany [55].…”

Section: Metabolic Dysfunctions and Diabetesmentioning

confidence: 89%

Long Covid: where we stand and challenges ahead

et al. 2022

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Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and colloquially as Long Covid, has been defined as a constellation of signs and symptoms which persist for weeks or months after the initial SARS-CoV-2 infection. PASC affects a wide range of diverse organs and systems, with manifestations involving lungs, brain, the cardiovascular system and other organs such as kidney and the neuromuscular system. The pathogenesis of PASC is complex and multifactorial. Evidence suggests that seeding and persistence of SARS-CoV-2 in different organs, reactivation, and response to unrelated viruses such as EBV, autoimmunity, and uncontrolled inflammation are major drivers of PASC. The relative importance of pathogenetic pathways may differ in different tissue and organ contexts. Evidence suggests that vaccination, in addition to protecting against disease, reduces PASC after breakthrough infection although its actual impact remains to be defined. PASC represents a formidable challenge for health care systems and dissecting pathogenetic mechanisms may pave the way to targeted preventive and therapeutic approaches.

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“…Such often association was observed among patients with COVID-19 ( 33 ). Obesity promotes a severe course of SARS-CoV-2 infection and increases the risk of respiratory failure ( 34 – 37 ). In our study, we have also observed an association between higher values of BMI and a symptomatic course of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Lifestyle, course of COVID-19, and risk of Long-COVID in non-hospitalized patients

Pływaczewska-Jakubowska

Chudzik

Babicki

et al. 2022

Front. Med.

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IntroductionThe coronavirus disease (COVID) 2019 pandemic remains a great challenge for the healthcare system. The widely reported prolonged signs and symptoms resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (Long-COVID) require medical care. The aim of the study was to assess factors, including lifestyle variables, related to the course of COVID-19 infection and to assess their impact on prolonged symptoms in non-hospitalized patients with COVID-19.MethodsA total of 1,847 (637 men and 1,210 women) non-hospitalized participants of the STOP-COVID registry of the PoLoCOV-Study who, following the COVID-19, underwent check-up examinations at the cardiology outpatient clinic were included in the analysis.ResultsThe study participants (median age 51 [41–62] years) were evaluated at 13.4 (8.4–23.6) weeks following the diagnosis of COVID-19. Female sex (odds ratio [OR] 1.46 [95% CI 1.19–1.78]), body mass index (BMI; per 1 kg/m2: 1.02 [1.00–1.04]), hypertension (1.39 [1.07–1.81]), asthma (1.55 [1.06–2.27]), stress or overworking (1.54 [1.25–1.90]), and nightshift work (1.51 [1.06–2.14]) were independently related to the severity of symptoms during acute phase of the COVID-19 infection. The Long-COVID syndrome was independently related to the female sex (1.42 [1.13–1.79]), history of myocardial infarction (2.57 [1.04–6.32]), asthma (1.56 [1.01–2.41]), and severe course of the acute phase of the COVID-19 infection (2.27 [1.82–2.83]).ConclusionFemale sex, BMI, asthma, hypertension, nightshifts, and stress or overworking are significantly related to the severity of the acute phase of the COVID-19 infection, while female sex, asthma, history of myocardial infarction, and the severity of symptoms in the acute phase of COVID-19 are the predictors of Long-COVID in non-hospitalized patients. We did not find an independent relation between Long-COVID and the studied lifestyle factors.

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Obesity and lipid metabolism disorders determine the risk for development of long COVID syndrome: a cross-sectional study from 50,402 COVID-19 patients

Cited by 33 publications

References 18 publications

Searching for Factors Influencing the Severity of the Symptoms of Long COVID

Searching for Factors Influencing the Severity of the Symptoms of Long COVID

Long Covid: where we stand and challenges ahead

Lifestyle, course of COVID-19, and risk of Long-COVID in non-hospitalized patients

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