Obesity and late-onset hypogonadism

Corona, Giovanni; Vignozzi, Linda; Sforza, Alessandra; Mannucci, Edoardo; Maggi, Mario

doi:10.1016/j.mce.2015.06.031

Cited by 127 publications

(106 citation statements)

References 103 publications

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“…29 In the limited number of RCTs that evaluated the combination of lifestyle modifications (diet and/or exercise) with T therapy (5 studies, 243 patients), the latter was found to provide additional benefits to lifestyle modifications alone. 33 A positive effect of T therapy on lumbar bone density is suggested by the few RCTs that investigated this issue. 34 In conclusion, T therapy for men with TD is effective, rational, and evidence based for issues related to sexual function and body composition.…”

Section: Resolution 4 T Therapy For Men With Td Is Effective Rationmentioning

confidence: 99%

Fundamental Concepts Regarding Testosterone Deficiency and Treatment

Morgentaler

Zitzmann²,

Traish

et al. 2016

Mayo Clinic Proceedings

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To address widespread concerns regarding the medical condition of testosterone (T) deficiency (TD) (male hypogonadism) and its treatment with T therapy, an international expert consensus conference was convened in Prague, Czech Republic, on October 1, 2015. Experts included a broad range of medical specialties including urology, endocrinology, diabetology, internal medicine, and basic science research. A representative from the European Medicines Agency participated in a nonvoting capacity. Nine resolutions were debated, with unanimous approval: (1) TD is a well-established, clinically significant medical condition that negatively affects male sexuality, reproduction, general health, and quality of life; (2) symptoms and signs of TD occur as a result of low levels of T and may benefit from treatment regardless of whether there is an identified underlying etiology; (3) TD is a global public health concern; (4) T therapy for men with TD is effective, rational, and evidence based; (5) there is no T concentration threshold that reliably distinguishes those who will respond to treatment from those who will not; (6) there is no scientific basis for any age-specific recommendations against the use of T therapy in men; (7) the evidence does not support increased risks of cardiovascular events with T therapy; (8) the evidence does not support increased risk of prostate cancer with T therapy; and (9) the evidence supports a major research initiative to explore possible benefits of T therapy for cardiometabolic disease, including diabetes. These resolutions may be considered points of agreement by a broad range of experts based on the best available scientific evidence.

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Section: Resolution 4 T Therapy For Men With Td Is Effective Rationmentioning

confidence: 99%

Fundamental Concepts Regarding Testosterone Deficiency and Treatment

Morgentaler

Zitzmann²,

Traish

et al. 2016

Mayo Clinic Proceedings

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“…Among obese patients, the incidence of hypogonadism is high. So there is a two-way relationship between the two conditions 8. The results of a meta-analysis show that obesity treatment is very effective for the associated hypogonadism as well 9…”

Section: Discussionmentioning

confidence: 99%

Obesity-related hypogonadism: a reversible condition

Zouras¹,

Stephens

Price

2017

BMJ Case Reports

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Obesity is associated with hypogonadism. While this association is widely accepted, the underlying mechanisms remain unclear. Furthermore, obesity is a risk factor for hypogonadism and conversely hypogonadism may be a risk factor for obesity. We present the case of a morbidly obese man aged 30 years with hypogonadotrophic hypogonadism that underwent a Roux-en-Y gastric bypass operation. Following the surgical treatment of his obesity, the testosterone level returned to normal with improvements in hypogonadal symptoms, which allowed discontinuation of exogenous testosterone therapy. This case report demonstrates reversal of hypogonadism following weight loss with restoration of gonadal function.

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“…(диеты и/или физических нагрузок), с терапией тесто-стероном (5 исследований с участием 243 пациентов), установлено, что последняя позволяла добиться допол-нительных благоприятных эффектов сверх результатов, достигаемых лишь при коррекции образа жизни [33]. Результаты того небольшого числа РКИ, где подоб-ный вопрос рассматривался, позволяют предполагать наличие благоприятного эффекта терапии тестосте-роном в отношении плотности костной ткани в пояс-ничных позвонках [34].…”

Section: заявление 3 дт представляет угрозу общественному здоровью вunclassified

The consensus recommendations of a group of international experts on the fundamental concepts related to the issues of testosterone deficiency and its treatment.

Morgentaler

Абрахам²,

Zitzmann³

et al. 2016

Obes. metabol.

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Conference on the development of the international expert consensus to address frequently asked questions related to a medical condition of testosterone deficiency (TD, male hypogonadism) and testosterone therapy was held in Prague (Czech Republic) on October 1, 2015. The included experts were representatives from a variety of medical specialties, including urology, endocrinology, diabetology, internal medicine, as well as representatives of basic medical sciences. An international team of experts came to the following conclusions: TD - an important medical condition that affects the health and well-being of men; TD symptoms is a consequence of low testosterone levels, regardless of whether background etiology installed; TD consequences are global; care must be taken in an attempt to use any uniform threshold levels of testosterone for a decision on the appointment of testosterone therapy; a person does not have any reason to refrain from appointing testosterone therapy only on the basis of age; the existing evidence does not suggest increasing the prostate cancer or cardiovascular disease risk during testosterone therapy; there is evidence conserning the feasibility of a major research initiative to explore possible cardioprotective beneficial effects of testosterone therapy in men with metabolic disorders, including diabetes.

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Obesity and late-onset hypogonadism

Cited by 127 publications

References 103 publications

Fundamental Concepts Regarding Testosterone Deficiency and Treatment

Fundamental Concepts Regarding Testosterone Deficiency and Treatment

Obesity-related hypogonadism: a reversible condition

The consensus recommendations of a group of international experts on the fundamental concepts related to the issues of testosterone deficiency and its treatment.

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