The consensus recommendations of a group of international experts on the fundamental concepts related to the issues of testosterone deficiency and its treatment.

Abstract

Conference on the development of the international expert consensus to address frequently asked questions related to a medical condition of testosterone deficiency (TD, male hypogonadism) and testosterone therapy was held in Prague (Czech Republic) on October 1, 2015. The included experts were representatives from a variety of medical specialties, including urology, endocrinology, diabetology, internal medicine, as well as representatives of basic medical sciences. An international team of experts came to the following conclusions: TD - an important medical condition that affects the health and well-being of men; TD symptoms is a consequence of low testosterone levels, regardless of whether background etiology installed; TD consequences are global; care must be taken in an attempt to use any uniform threshold levels of testosterone for a decision on the appointment of testosterone therapy; a person does not have any reason to refrain from appointing testosterone therapy only on the basis of age; the existing evidence does not suggest increasing the prostate cancer or cardiovascular disease risk during testosterone therapy; there is evidence conserning the feasibility of a major research initiative to explore possible cardioprotective beneficial effects of testosterone therapy in men with metabolic disorders, including diabetes.

Current understanding of the role of age-related hypogonadism in the development of cardiovascular diseases

“…Таким образом, дисфункция эндотелия является начальным этапом развития атеросклероза и других ссЗ [32]. Такая патогенетическая цепочка может быть одним из механизмов влияния дефицита Тс на развитие атеросклероза, что подтверждается многими авторами и исследованиями с более частым выявлением атеросклеротических бляшек у мужчин с вГ по сравнению с мужчинами общей популяции [6,23,39,47]. Некоторые исследования показывают наличие корреляции между уровнем Тс, толщиной ком-плекса интима-медиа сонных артерий и степенью окклюзии коронарных артерий [6,47].…”