Obesity and its Implications on Stress Urinary Incontinence

Dumitrașcu, Mihai Cristian; Stănescu, Ana Maria Alexandra; Bejan, Cristian Gabriel; Şandru, Florica; Toader, Daniela Oana; Radavoi, D.; Cotirlet, Adrian; Pusta, Claudia Teodora Judea; Diaconu, Camelia Cristina

doi:10.37358/rc.19.10.7617

Cited by 13 publications

(12 citation statements)

References 37 publications

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“…Patients need to be educated on their comorbidities. In case of our patient, who had associated dyslipidemia and obesity, it was important to inform her of the risks of visceral fat level (especially when treatment with methotrexate was administered) (19).…”

Section: Discussionmentioning

confidence: 99%

Etiologic role of Borrelia�burgdorferi in morphea: A case report

et al. 2020

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Morphea is an inflammatory skin disease with self-limited evolution, presenting as localized sclerosis of the skin and/or underlying tissues. The incidence is not exactly known; the disease occurs more frequently in women, and there is no sex prevalence. Pathogenesis of morphea remains still controversial. Several theories exist and the Borrelia burgdorferi infection is not yet elucidated. The aim of this report is to present the main mechanisms involved in the etiophatogenesis of morphea and also the thepapeutic options. A case of a 60-year-old woman is presented, who was referred to the clinic for an erythematous-violaceus, asymptomatic eruption, located on the trunk and legs, for appoximately 2 months. The patient's medical history revealed an infection with Borrelia 1 year previously. After diagnosis of morphea was established, and with systemic therapy (corticosteroids and methotrexate), the evolution was favorable.

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Section: Discussionmentioning

confidence: 99%

Etiologic role of Borrelia�burgdorferi in morphea: A case report

et al. 2020

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“…A further aim was to identify possible predictors of liver damage by analyzing specific anthropometric data (10). There was also a focus on visceral fat which is associated with a number of conditions, including cardiovascular disease, and insulin resistance during the process of visceral adipose tissue collection in the abdominal cavity and surrounding of the internal organs (11).…”

Section: The Dynamic Changes In the Pattern Of Liver Function Tests In Pregnant Obese Womenmentioning

confidence: 99%

The dynamic changes in the pattern of liver function tests in pregnant obese women

et al. 2021

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Obesity is an important problem in healthcare regarding gestating women. The objective of the present study was to highlight the impact that obesity has on the hepatic function in pregnant women by comparing the functional tests used in current practice. In addition, the aim was to identify possible predictors of liver damage by analyzing specific anthropometric data. The present study was descriptive, observational, retrospective, and based on the observation sheets found in the database of the Institute for the Health of the Mother and Child, the Obstetrics Gynecology Department of Polizu Hospital. Patients who presented for consultation in each trimester of pregnancy were included in the study. Demographic data taken into account included age, body mass index (BMI), provenance environment, anthropometric data: Abdominal circumference and the complete set of paraclinical data from which we extracted these specific liver tests: Aspartate aminotransferase (AST), alanine transferase (ALT), direct bilirubin (BD), serum albumin and gamma-glutamyl transferase (GGT). The present study included 157 patients divided into two groups, distributed as follows: Group A: 66 obese pregnant women (BMI >25 kg/m 2 ) and group B: 91 patients with normal weight (BMI <25 kg/m 2 ). Measurement of serum ALT and AST were the most useful tests for routine diagnosis of liver disease. The effects of pregnancy on serum levels of ALT and AST are controversial. In some studies, there was a slight increase in ALT and AST during the second and third trimesters, a fact confirmed by our study, albeit the result was not statistically significant Most published studies claim that serum ALT and AST levels do not change during pregnancy. In conclusion, obesity during pregnancy does not drastically influence liver function. However, patients with greater abdominal circumference are prone to developing minor hepatic cytolysis syndrome during the gestation period. The liver functional tests described in the aforementioned groups agree with the results provided by the specialized studies.

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“…Central somatostatin is produced by hypothalamus and it displays also inhibitory effects on pituitary growth hormone, thyroid stimulating hormone (TSH) and prolactin (17). SRs are widespread in the brain and their activation communicates with the modulation of food and water intake and recently they have been linked with obesity pathogenesis (17)(18)(19). Further innovative approaches of obesity are currently under development and they include anti-obesity vaccines with hormone analogues such as somatostatin or ghrelin (20).…”

Section: Somatostatin: a General Perspectivementioning

confidence: 99%

Somatostatinoma: Beyond neurofibromatosis type 1 (Review)

Şandru

Cârșote

Valea³

et al. 2020

Exp Ther Med

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Somatostatinoma is a tumour mainly originating from pancreas or duodenum; overall with an incidence of 1/40 million persons. We introduce a narrative review of literature of somatostatinoma including the relationship with neurofibromatosis type 1. Clinical presentation includes: Diabetes mellitus, cholelithiasis, steatorrhea, abdominal pain, and obstructive jaundice while papillary tumour may cause acute pancreatitis. The neoplasia may develop completely asymptomatic or it is detected as an incidental finding during an imaging or a surgical procedure. It may be sporadic or associated to genetic backgrounds especially for duodenal localisation as neurofibromatosis type 1 (NF1 gene with malfunction of RAS/MAPK pathway) or Pacak-Zhuang syndrome (EPAS1 gene encoding HIF). Surgery represents the central approach if feasible but the prognostic depends on location, and grading as indicated by WHO 2017 classification of neuroendocrine tumours. Previously known as Von Recklinghausen disease, neurofibromatosis type 1, the most frequent neurocutaneous syndrome, is an autosomal dominant disorder including: Café-au-lait spot, skin fold freckling on flexural zones, and neurofibromas as well as tumours such as gliomas of optic nerve, gastrointestinal stromal tumours (GISTs), iris hamartomas and brain tumours. Duodenal somatostatinoma is associated with the syndrome which actually involves more often a duodenal tumour of GIST type than a somatostatin secreting neoplasia. Other neuroendocrine tumours are reported: Gastrointestinal NENs at the level of rectum or jejunum and pheocromocytoma. Overall, one quarter of subjects have gastrointestinal tumours of different types. Somatostatinoma, when not located on pancreas but in duodenoum, may be registered in subjects with neurofibromatosis type 1 most probably in addition to other tumours. Overall, this type of neuroendocrine tumour with a challenging presentation has a poor prognosis unless adequate radical surgery is promptly offered to the patient.

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Obesity and its Implications on Stress Urinary Incontinence

Cited by 13 publications

References 37 publications

Etiologic role of Borrelia�burgdorferi in morphea: A case report

Etiologic role of Borrelia�burgdorferi in morphea: A case report

The dynamic changes in the pattern of liver function tests in pregnant obese women

Somatostatinoma: Beyond neurofibromatosis type 1 (Review)

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