Etiologic role of Borrelia�burgdorferi in morphea: A case report

Abstract

Morphea is an inflammatory skin disease with self-limited evolution, presenting as localized sclerosis of the skin and/or underlying tissues. The incidence is not exactly known; the disease occurs more frequently in women, and there is no sex prevalence. Pathogenesis of morphea remains still controversial. Several theories exist and the Borrelia burgdorferi infection is not yet elucidated. The aim of this report is to present the main mechanisms involved in the etiophatogenesis of morphea and also the thepapeutic options. A case of a 60-year-old woman is presented, who was referred to the clinic for an erythematous-violaceus, asymptomatic eruption, located on the trunk and legs, for appoximately 2 months. The patient's medical history revealed an infection with Borrelia 1 year previously. After diagnosis of morphea was established, and with systemic therapy (corticosteroids and methotrexate), the evolution was favorable.

Morphea in two patients after being infected to and being vaccinated against SARS‐CoV‐2 infection

“…17 Borrelia burgdorferi has been the most common infective pathogen reported to be associated with morphea. 18 Other infections with probable association include hepatitis B virus (HBV), hepatitis C virus (HCV), cytomegalovirus (CMV), toxoplasma, helicobacter pylori, and human endogenous retroviruses (HERV). 19 , 20 , 21 , 22 , 23 , 24 , 25 Recently, we have confronted with cases of morphea following SARS‐CoV‐2 infection.…”

“…Morphea might be related to some environmental factors such as trauma, radiation, medications, infections, and vaccines 17 . Borrelia burgdorferi has been the most common infective pathogen reported to be associated with morphea 18 . Other infections with probable association include hepatitis B virus (HBV), hepatitis C virus (HCV), cytomegalovirus (CMV), toxoplasma, helicobacter pylori, and human endogenous retroviruses (HERV) 19–25 .…”

Morphea (Localized Scleroderma) in a COVID-19 patient: A Case Report

“…Earlier studies describe viral infections as a risk factors for Morphea, respectively CMV, Borrelia [9]. Although the origin of LSc is unknown, it is postulated that the disease process is related to immune activation and vascular damage that leads to connective tissue dysregulation [4].…”

Clostridium difficile infection characteristics in a general surgery clinic

“…It is well known that surgery, and particularly gastrointestinal surgery, may predispose patients to the development of CDIs. Some reasons for this are the widespread use of broad-spectrum antibiotics, the increasing number of surgeries on the elderly and the immuno-compromised as well as the emergence of more virulent strains of bacteria (ribotype 027) (13)(14)(15). In regards to digestive surgeries, patients with the highest risk for an ulterior CDI development are those undergoing colectomies, small-bowel resections and gastrectomies (10).…”