Obesity and immune cell counts in women

Womack, Julie A.; Tien, Phyllis C.; Feldman, Joseph; Shin, Joongho; Fennie, Kristopher; Anastos, Kathryn; Cohen, Mardge H.; Bacon, Melanie C.; Minkoff, Howard

doi:10.1016/j.metabol.2007.03.008

Cited by 121 publications

(106 citation statements)

References 34 publications

(33 reference statements)

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“…The most consistent association was found between the number of white blood cells and the measurements of generalized and abdominal obesity, namely BMI and circumference of the waist. Also Womack et al (2007) [17] found; there is strong evidence of an association between obesity and the white blood cells count increases in a female population. Studies have found that, there is some sort of association between the increased number of immune cells and obesity as a result of a chronic inflammatory condition which is created by an increase in the production of cytokines by adipose tissue.…”

Section: Discussionmentioning

confidence: 90%

Association Between Obesity, White Blood Cell and Platelet Count

Jamshidi

Seif

2017

Zahedan J Res Med Sci

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Background: Cardiovascular disease is resulted from malfunctioning's of heart as well as blood vessels. More than two decades ago it was noted that the number of white blood cells can be an indicated of the existence of such disease. Platelet activation and aggregation are among the include processes. That are considered in pathophysiology of a coronary heart disease. However there seems to be a paucity of research on platelet count in patients suffering from obesity. Moreover although previous studies have indicated a positive correlation between platelet and white blood cells. Counts and mortality from coronary heath disease, how this might correlate with obesity is an issue still in need of more attention. Objectives: The present study was designed to evaluate platelet count and white blood cell count in those patients who suffer from obesity as compared with control subjects who were not obese. Methods: In this cross-sectional study, there were a total of 1024 Iranian subjects living in Hamedan include, staff of Islamic Azad University of Hamedan and subjects who referred to Ekbatan hospital in Hamedan during the period of 6 months randomly and staff of Islamic Azad University of Hamedan. The absence of infectious disease was confirmed by a general practitioner. Finally, the samples included 486 subjects, 254 male, and 232were females. Body mass index was calculated. Waist circumference in the Iranian subjects, at least in men 89 (cm) and women 91 (cm) was considered. White blood cell and platelet count was measured. T-test and Pearson's correlation were run to analyze the collected data through SPSS software version 16.

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Section: Discussionmentioning

confidence: 90%

Association Between Obesity, White Blood Cell and Platelet Count

Jamshidi

Seif

2017

Zahedan J Res Med Sci

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“…To our knowledge, none of our women had an infection during baseline testing and no women exhibited an elevated white blood cell count (O11!10 9 /l). Research has indicated that white blood cell count is related to body fat in humans (33), suggesting that adipocytokines may be involved in the adipocyte-induced inflammatory response. Further, Vozarova et al (34) found that with a high white blood cell count, insulin sensitivity declined in nondiabetic Pima Indians.…”

Section: Discussionmentioning

confidence: 99%

Centrally located body fat is related to appetitive hormones in healthy postmenopausal women.

Ritland¹,

Alekel²,

Matvienko³

et al. 2008

European Journal of Endocrinology

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Objective: Body composition and energy homeostasis are thought to affect the appetitive hormones: adiponectin, leptin, insulin, and ghrelin. This study examined whether centrally located fat and/or overall adiposity were related to these appetitive hormones in healthy postmenopausal women. Design: Overall and regional body composition was assessed by dual-energy X ray absorptiometry in relation to plasma adiponectin, serum leptin, serum insulin, and plasma ghrelin in 242 postmenopausal women. Results: Regression analyses revealed that the androidal-to-gynoidal fat mass ratio (18.0%), age (3.2%), and white blood cell count (1.8%) accounted for 28% of the variability in adiponectin (FZ22.2; P!0.0001); androidal (waistChip) fat mass (66.0%), androidal fat mass 2 (6.2%), wholebody lean mass (2.2%), and age (0.8%) accounted for 69% of the variability in leptin (FZ102.5; P!0.0001). Regression analyses revealed that sagittal abdominal diameter (8.4%), glucose (5.4%), white blood cell count (2.6%), and dietary u-3 fatty acids (2.0%) accounted for 32% of the variability in insulin (FZ20.8; P!0.0001); waist circumference (12.7%), hip lean mass (2.0%), and white blood cell count (1.9%) accounted for 26% of the variability in ghrelin (FZ20.7; P!0.0001). Our results indicated that centralized fat mass was the primary contributor to these appetitive hormones in healthy postmenopausal women. Conclusion: Since central adiposity in postmenopausal women was related to appetitive hormones, minimizing weight gain during the menopausal transition may optimize appetitive hormones, thereby facilitating appetite control and weight maintenance.European Journal of Endocrinology 158 889-897

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“…an increase in the CD4 + T cell count in BP of the examined patients with T2D, which is also observed in MS and IR, as well as in normoglycemic obese individuals [12,36,39]. And weight loss as a result of diet or surgical removal of FT excess, the content of this subpopulation of T-lymphocytes in BP decreases [27].…”

Section: Discussionmentioning

confidence: 57%