Obesity and Dyslipidemia

Franssen, Remco; Monajemi, Houshang; Stroes, Erik S.G.; Kastelein, John J.P.

doi:10.1016/j.mcna.2011.06.003

Cited by 199 publications

(137 citation statements)

References 58 publications

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“…Because ABCA1 is a major mediator of cholesterol effl ux ( 9, 10 ), we evaluated whether loss of ABCA1 in adipocytes raises adipose cholesterol content. We observed a significant increase in the cholesterol content in GAT, SAT, and HDL ( 19,28 ). In order to assess the contribution of adipocyte ABCA1 to plasma lipid metabolism, we measured total cholesterol, HDL, TGs, and NEFAs in the plasma of wild-type and ABCA1 Ϫ ad/ Ϫ ad mice.…”

Section: Adipocyte Abca1 Defi Ciency Increases Fat Pad Weight On An Hmentioning

confidence: 96%

“…Obesity and adipose dysfunction not only have consequences on plasma lipids but also have been associated with hepatosteatosis ( 21 ). Although the precise mechanism by which adipose tissue affects lipid accumulation in the liver remains unclear, increased NEFA fl ux, decreased adiponectin and visfatin expression, and insulin resistance may all play a role ( 1,20,21,28 ). To assess the effect of adipose ABCA1 on the liver, we measured liver weight and hepatic lipid content in ABCA1…”

Section: Adipocyte Abca1 Defi Ciency Increases Fat Pad Weight On An Hmentioning

confidence: 99%

“…These alterations in lipid homeostasis and gene expression are and obesity, and ABCA1 has been shown to mediate cholesterol effl ux from adipose tissue ( 7,9,15 ). Adipose tissue dysfunction is an important risk factor for the development of glucose intolerance, insulin resistance, and type 2 diabetes ( 3,19,28 ); this indicates a role for adipocyte cholesterol and ABCA1 in these conditions.…”

Section: Adipocyte Abca1 Defi Ciency Impairs Glucose Tolerance Reducmentioning

confidence: 99%

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ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity

Haan

Bhattacharjee

Ruddle

et al. 2014

Journal of Lipid Research

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Section: Adipocyte Abca1 Defi Ciency Increases Fat Pad Weight On An Hmentioning

confidence: 96%

Section: Adipocyte Abca1 Defi Ciency Increases Fat Pad Weight On An Hmentioning

confidence: 99%

Section: Adipocyte Abca1 Defi Ciency Impairs Glucose Tolerance Reducmentioning

confidence: 99%

See 1 more Smart Citation

ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity

Haan

Bhattacharjee

Ruddle

et al. 2014

Journal of Lipid Research

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“…On the other hand, abnormal fasting serum or plasma lipid levels are the most prominent symptoms resulting from obesity 19 , and the effect of 25(OH) D supplementation on lipid profiles remains controversial 20 .…”

Section: (Oh)d Deficiency Is An Important Public Healthmentioning

confidence: 99%

Low serum 25(OH)D levels are assocıated to hıgher BMI and metabolic syndrome parameters in adult subjects in Turkey

Tosunbayraktar¹,

Baş²,

Kut³

et al. 2016

Afr H. Sci.

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Background: The aim of this study was to investigate the association of 25(OH)D levels with biochemical, anthropometric, and metabolic data obtained from normal and obese people. Methods: This study was carried out on 90 individuals between the ages of 18 to 63 that had various body mass indexes. Blood samples and anthropometric measurements were taken. Results: Waist circumferences, fat mass, LDL cholesterol levels, HDL cholesterol levels, 25(OH)D levels, and triglyceride levels were significantly different according to the body mass index groups of the participants (p<0.05). When compared to the normal body mass index group, both other groups (overweight and obese) had higher waist circumferences, triglyceride levels, LDL cholesterol levels, fasting insulin levels, HOMA-IR ratios, parathyroid hormone levels, and fat mass, and had lower 25(OH)D levels (p<0.05). The overweight group participants had higher 25(OH)D levels than the obese group, and had lower waist circumferences, fat mass, fasting insulin level, HOMA-IR ratios, and HbA1C and PTH levels than those in the obese group (p<0.05). Conclusion: In conclusion, the mean level of 25(OH)D is very low in overweight and obese individuals and low serum 25(OH)D levels appear to be associated with obesity, visceral obesity, hypertriglyceridemia, insulin resistance, and metabolic syndrome in obese patients.

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“…When western and traditional diets are compared, the western diet promotes consumption of high-fat, high-sugar foods with excess calorie intake, leading to obesity and overweight (4). Obesity and overweight are a global problem associated with dyslipidemia, diabetes, cardiovascular disease, autoimmune disease, and some cancers (5,6). Currently available antiobesity drugs are mostly unsatisfactory due to severe side effects (7).…”

Section: Introductionmentioning

confidence: 99%

Anti-adipogenic effects in 3T3-L1 cells of acetone extracts and fractions from Styrax japonica fruit

Kim

Nam

Kim

et al. 2015

Food Sci Biotechnol

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Reduction in reactive oxygen species (ROS) production facilitated by Styrax japonica (SJ) extracts and fractions for inhibition of obesity development through inhibition of adipogenesis was investigated. Treatment of cells with SJ extracts and fractions did not result in changes in cell viability. SJ extracts and fractions inhibited lipid accumulation in a dose-dependent manner during adipogenesis. Expressions of PPARγ and C/EBPα, key adipogenic markers, were decreased in cells treated with SJ extracts and fractions. Inhibitory effects of SJ extracts and fractions were the most powerful in the early stages of differentiation (days 0-2). Intracellular ROS production was decreased in cells treated with SJ extracts and fractions. SJ extracts and fractions can inhibit adipogenesis via reduced ROS levels, which involves down-regulation of adipogenic transcription factors.

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Obesity and Dyslipidemia

Cited by 199 publications

References 58 publications

ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity

ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity

Low serum 25(OH)D levels are assocıated to hıgher BMI and metabolic syndrome parameters in adult subjects in Turkey

Anti-adipogenic effects in 3T3-L1 cells of acetone extracts and fractions from Styrax japonica fruit

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