Obesity and cardiovascular disease in women

Manrique‐Acevedo, Camila; Chinnakotla, Bhavana; Padilla, Jaume; Martinez‐Lemus, Luis A.; Gozal, David

doi:10.1038/s41366-020-0548-0

Cited by 69 publications

(52 citation statements)

References 248 publications

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“…Although men suffer CVD at an earlier age and a higher age-specific rate than women, women have been shown to have several disadvantages in terms of CVD compared to men. These inequalities are associated with a higher cardiac risk factor burden in women, including a higher prevalence of systemic inflammatory rheumatologic diseases, mental stress/depression, polycystic ovarian syndrome, and factors related to reproductive health (e.g., pregnancy-induced hypertension, preeclampsia, gestational diabetes) [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Duration of Lactation and Maternal Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis

Tørris

Bjørnnes

2020

Nutrients

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Cardiovascular disease (CVD) is the leading cause of death of women across all ages, and targeting modifiable risk factors, such as those comprised in metabolic syndrome (MetS) (e.g., waist circumference, lipid profile, blood pressure, and blood glucose), is of great importance. An inverse association between lactation and CVD has been suggested, and lactation may decrease the risk of MetS. This systematic review and meta-analysis examined how lactation may affect the development and prevalence of MetS in women. A literature search was performed using Cinahl, Embase, Web of Science, and PubMed. A total of 1286 citations were identified, and finally, ten studies (two prospective and eight cross-sectional) were included. Seven studies (two prospective and five cross-sectional) revealed associations between lactation and MetS, suggesting that breastfeeding might prevent or improve metabolic health and have a protective role in MetS prevention. This protective role might be related to the duration of lactation; however, a lack of controlling for potential confounders, such as parity, might inflict the results. The pooled effect was non-conclusive. Additional research is required to further explore the duration of lactation and its potential role in improving or reversing MetS and its components.

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Section: Introductionmentioning

confidence: 99%

Duration of Lactation and Maternal Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis

Tørris

Bjørnnes

2020

Nutrients

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“…Dose-response associations of CVD risk with sitting time and patterns was demonstrated in a large cohort study among older women (age range 63-97 years) 2 . Postmenopausal women have increased risk for overweight/obesity and insulin resistance, which further elevates CVD risk 23 . Clinical and epidemiological evidence indicate that research studies among postmenopausal women is urgently needed to enhance healthy aging and quality of life for this special population.…”

Section: Discussionmentioning

confidence: 99%

Endothelial-derived cardiovascular disease-related microRNAs elevated with prolonged sitting pattern among postmenopausal women

Chang

Tuz-Zahra

Godbole

et al. 2021

Sci Rep

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Time spent sitting is positively correlated with endothelial dysfunction and cardiovascular disease risk. The underlying molecular mechanisms are unknown. MicroRNAs contained in extracellular vesicles (EVs) reflect cell/tissue status and mediate intercellular communication. We explored the association between sitting patterns and microRNAs isolated from endothelial cell (EC)-derived EVs. Using extant actigraphy based sitting behavior data on a cohort of 518 postmenopausal overweight/obese women, we grouped the woman as Interrupted Sitters (IS; N = 18) or Super Sitters (SS; N = 53) if they were in the shortest or longest sitting pattern quartile, respectively. The cargo microRNA in EC-EVs from the IS and SS women were compared. MicroRNA data were weighted by age, physical functioning, MVPA, device wear days, device wear time, waist circumference, and body mass index. Screening of CVD-related microRNAs demonstrated that miR-199a-5p, let-7d-5p, miR-140-5p, miR-142-3p, miR-133b level were significantly elevated in SS compared to IS groups. Group differences in let-7d-5p, miR-133b, and miR-142-3p were validated in expanded groups. Pathway enrichment analyses show that mucin-type O-glycan biosynthesis and cardiomyocyte adrenergic signaling (P < 0.001) are downstream of the three validated microRNAs. This proof-of-concept study supports the possibility that CVD-related microRNAs in EC-EVs may be molecular transducers of sitting pattern-associated CVD risk in overweight postmenopausal women.

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“…Chronic inflammatory states which are identified with high levels of pro-inflammatory risk markers are involved in the pathogenesis of all stages of CVDs [2][3][4]. It has been shown that women with obesity have a higher probability of developing cardiovascular disorders than women with normal weight [5]. One of the important modifiable factor that contributes to chronic inflammatory state is diet [6].…”

Section: Introductionmentioning

confidence: 99%

High carbohydrate intakes may predict more inflammatory status than high fat intakes in pre-menopause women with overweight or obesity: a cross-sectional study

et al. 2021

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Objective The associations between dietary carbohydrate, fat intake, and inflammation are controversial. Most existing data are from industrialized societies which low-carbohydrate and high-fat diet is common and so their attribution to other populations remains unclear. We evaluated the association of fat and carbohydrate intakes with inflammatory markers in pre-menopause women with overweight or obesity in Iran. Results Three hundred and sixty women with body mass index (BMI) ≥ 25 were included to this study. The levels of monocyte chemoattractant protein-1 (MCP-1) indicated a trend towards significance across tertiles of total dietary carbohydrate. We found that the levels of galectin-3 were negatively associated with dietary carbohydrate in adjusted model. In addition, the levels of MCP-1 and transforming growth factor beta (TGF-β) were positively correlated to dietary carbohydrate. No significant relationship was demonstrated between inflammatory parameters and total fat intake). However, there was a borderline significant negative association between total fat intake and TGF-β level in adjusted model. Therefore, a total dietary carbohydrate were related to elevated inflammation risk, while a total fat intake were not associated to higher inflammation. This study suggests reconsideration of applying global dietary guidelines in societies with high carbohydrate diet.

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Obesity and cardiovascular disease in women

Cited by 69 publications

References 248 publications

Duration of Lactation and Maternal Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis

Duration of Lactation and Maternal Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis

Endothelial-derived cardiovascular disease-related microRNAs elevated with prolonged sitting pattern among postmenopausal women

High carbohydrate intakes may predict more inflammatory status than high fat intakes in pre-menopause women with overweight or obesity: a cross-sectional study

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