High carbohydrate intakes may predict more inflammatory status than high fat intakes in pre-menopause women with overweight or obesity: a cross-sectional study

Karimi, Elmira; Yarizadeh, Habib; Setayesh, Leila; Sajjadi, Seyyedeh Forough; Ghodoosi, Nasim; Khorraminezhad, Leil

doi:10.1186/s13104-021-05699-1

Cited by 11 publications

(8 citation statements)

References 43 publications

(52 reference statements)

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“…We and others previously demonstrated that under pathological conditions, high-carbohydrate RD promotes inflammation [ 38 , 39 , 40 , 41 ]. In addition, it has been shown that the pro-inflammatory transcription factor NF-κB plays a crucial role in the metabolic profile of pediatric sarcomas, potentially through the regulation of glycolysis (HK2) [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Diets Differently Regulate Tumorigenesis in Young E0771 Syngeneic Breast Cancer Mouse Model

Thangavel

Lizardo

Dhanyalayam

et al. 2023

JCM

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Breast cancer (BC) is the most diagnosed cancer type, accounting for one in eight cancer diagnoses worldwide. Epidemiological studies have shown that obesity is associated with increased risk of BC in post-menopausal women, whereas adiposity reduces the risk of BC in premenopausal women. The mechanistic link between obesity and BC has been examined by combining murine BC models with high-fat diet (HFD) induced obesity. However, the effect of adiposity (not obesity) induced by a short period of HFD consumption on BC pathogenesis is not well understood. In the current study, we examined the effects of different diet compositions on BC pathogenesis using a young E0771 syngeneic BC mouse model fed on either an HFD or regular diet (RD: a low-fat high-carbohydrate diet) for a short period (4 weeks) before implanting mammary tumors in mice. We analyzed the effect of diet composition on the onset of tumor growth, metastasis, and metabolic and immune status in the tumor microenvironment (TME) using various methods including in vivo bioluminescence imaging and immunoblotting analyses. We showed for the first time that a short-term HFD delays the onset of tumorigenesis by altering the immune and metabolic signaling and energy mechanism in the TME. However, RD may increase the risk of tumorigenesis and metastasis by increasing pro-inflammatory factors in the TME in young mice. Our data suggest that diet composition, adipogenesis, and loss of body fat likely regulate the pathogenesis of BC in a manner that differs between young and post-menopausal subjects.

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Section: Discussionmentioning

confidence: 99%

Diets Differently Regulate Tumorigenesis in Young E0771 Syngeneic Breast Cancer Mouse Model

Thangavel

Lizardo

Dhanyalayam

et al. 2023

JCM

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“…In vivo studies have revealed that high dietary cholesterol leads to increased adipocyte size, expression of pro-inflammatory cytokines, and macrophage infiltration (72,73). Karimi et al reported that high carbohydrate intake had a positive association with monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor beta (TGF-β) that were related to increased expression of NF-κB as the main regulator of pro-inflammatory cytokine expression (74).…”

Section: Discussionmentioning

confidence: 99%

The association between inflammatory and immune system biomarkers and the dietary inflammatory index in patients with COVID-19

et al. 2023

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BackgroundInflammation and cytokine storm have been reported to be the main cause of acute symptoms of coronavirus disease (COVID-19). Diet-induced inflammation may affect the condition of patients with COVID-19. Therefore, this study aimed to investigate the relationship between disease severity, inflammatory and immune system biomarkers, and the dietary inflammatory index (DII) in patients with COVID-19.MethodsThis cross-sectional study was conducted on 500 adult patients with COVID-19. Patients were divided into mild, moderate, and severe conditions based on clinical and laboratory evidence. A validated food frequency questionnaire (FFQ) was used to determine DII and energy-adjusted DII (E-DII) scores. The serum C-reactive protein (CRP) level and blood cell count were measured for all patients. Multiple linear regression was used to explore the association between DII and E-DII and CRP, blood cell counts, and hospitalization in patients with COVID-19.ResultsCoronavirus disease (COVID-19) patients with higher DII had higher consumption of fat and carbohydrate and lower intakes of protein, anti-inflammatory nutrients, garlic, caffeine, tea, onion, and fiber (P < 0.05). There was a positive association between DII and CRP (β = 1.024, P < 0.001), hospitalization (β = 1.062, P < 0.001), WBC count (β = 0.486, P < 0.009), neutrophil count (β = 0.565, P < 0.001), and neutrophil-to-lymphocyte ratio (β = 0.538, P < 0.001) and a negative association between DII and the lymphocyte count (β = −0.569, P < 0.001). There was a positive association between E-DII and hospitalization (β = 1.645, P < 0.001), WBC count (β = 0.417, P < 0.02), and neutrophil-to-lymphocyte ratio (β = 0.35, P < 0.03).ConclusionThere is a positive correlation between DII and inflammation, immune hyperactivation, and length of hospital stay in patients with COVID-19. Further longitudinal studies are necessary.

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“…Our results also showed that the association of Lactococcus and carbohydrate linked to the higher symptoms of depression. Recent studies have suggested that high carbohydrate consumption is associated with increased circulating inflammatory markers (Karimi et al, 2021). Mice fed with carbohydrate-enriched diet showed higher levels of obesity, which may also facilitate the development of depressive-like behaviors after the stress (Santos et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Evaluating the interactive effects of dietary habits and human gut microbiome on the risks of depression and anxiety

Yao

Jia

et al. 2022

Psychol. Med.

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Background Gut microbiome and dietary patterns have been suggested to be associated with depression/anxiety. However, limited effort has been made to explore the effects of possible interactions between diet and microbiome on the risks of depression and anxiety. Methods Using the latest genome-wide association studies findings in gut microbiome and dietary habits, polygenic risk scores (PRSs) analysis of gut microbiome and dietary habits was conducted in the UK Biobank cohort. Logistic/linear regression models were applied for evaluating the associations for gut microbiome-PRS, dietary habits-PRS, and their interactions with depression/anxiety status and Patient Health Questionnaire (PHQ-9)/Generalized Anxiety Disorder-7 (GAD-7) score by R software. Results We observed 51 common diet–gut microbiome interactions shared by both PHQ score and depression status, such as overall beef intake × genus Sporobacter [hurdle binary (HB)] (PPHQ = 7.88 × 10−4, Pdepression status = 5.86 × 10−4); carbohydrate × genus Lactococcus (HB) (PPHQ = 0.0295, Pdepression status = 0.0150). We detected 41 common diet–gut microbiome interactions shared by GAD score and anxiety status, such as sugar × genus Parasutterella (rank normal transformed) (PGAD = 5.15 × 10−3, Panxiety status = 0.0347); tablespoons of raw vegetables per day × family Coriobacteriaceae (HB) (PGAD = 6.02 × 10−4, Panxiety status = 0.0345). Some common significant interactions shared by depression and anxiety were identified, such as overall beef intake × genus Sporobacter (HB). Conclusions Our study results expanded our understanding of how to comprehensively consider the relationships for dietary habits–gut microbiome interactions with depression and anxiety.

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High carbohydrate intakes may predict more inflammatory status than high fat intakes in pre-menopause women with overweight or obesity: a cross-sectional study

Cited by 11 publications

References 43 publications

Diets Differently Regulate Tumorigenesis in Young E0771 Syngeneic Breast Cancer Mouse Model

Diets Differently Regulate Tumorigenesis in Young E0771 Syngeneic Breast Cancer Mouse Model

The association between inflammatory and immune system biomarkers and the dietary inflammatory index in patients with COVID-19

Evaluating the interactive effects of dietary habits and human gut microbiome on the risks of depression and anxiety

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