RETRACTED: Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis

Khosravaniardakani, Sheida; Bokov, Dmitry Olegovich; Mahmudiono, Trias; Hashemi, Seyedeh Sedigheh; Nikrad, Negin; Rabieemotmaen, Shadi; Farhangi, Mahdieh Abbasalizad

doi:10.3389/fnut.2022.812846

Cited by 12 publications

(1 citation statement)

References 72 publications

(117 reference statements)

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“…This finding is consistent with data from a previous study that also found a negative association between relative telomere length and the percentage of body fat and visceral fat (Nantanawut et al., 2022). Furthermore, other supportive studies have shown a clear negative correlation between obesity and telomere length (Khosravaniardakani et al., 2022; Nonino et al., 2018). Obesity is a vital underlying factor in the development of metabolic syndrome.…”

Section: Discussionmentioning

confidence: 81%

Efficacy of a dietary supplement derived from five edible plants on telomere length in Thai adults: A randomized, double‐blind, placebo‐controlled trial

Praengam,

Tuntipopipat,

Muangnoi

et al. 2023

Food Science & Nutrition

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Mylife/Mylife100® is a dietary supplement consisting of black sesame seed, guava fruit, mangosteen aril, pennywort leaves, and soy protein. These edible plants contain multiple high‐potential bioactive compounds exerting various vital biological functions including antioxidants which contribute to delaying the rate of telomere shortening. Telomere length is associated with cellular aging and age‐related diseases. This study aimed to assess the efficacy of Mylife/Mylife100® on telomere length through a randomized, double‐blind placebo‐controlled trial. The trial assessed the alteration of leukocyte telomere length after 32 adults aged 50–65 years received either Mylife/Mylife100® or placebo (five capsules/day) for 8‐week supplementation. The results demonstrated a significant increase in mean telomere length from baseline (6313 bp) to the 8‐week supplementation period (6655 bp; p < 0.05) in the group receiving the product, whereas no significant change was observed in the placebo group. Additionally, the product group exhibited a significant improvement in plasma total antioxidant capacity levels compared to the placebo group (mean change, +35 vs −38; p = 0.006). This study also showed a significant correlation between telomere length and % CD4 + T cells (r = +0.325; p = 0.00003), % CD8 + T cells (r = +0.156; p = 0.048), and visceral fat (r = − 0.349; p = 0.000006). The findings suggest that consuming this dietary supplement (Mylife/Mylife100®) for 8 weeks has a positive effect on cellular aging by lengthening telomeres possible through their antioxidant capacities. Oxidative stress and cellular aging are underlying predisease mechanisms that might be alleviated by supplementing with this product.

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Section: Discussionmentioning

confidence: 81%

Efficacy of a dietary supplement derived from five edible plants on telomere length in Thai adults: A randomized, double‐blind, placebo‐controlled trial

Praengam,

Tuntipopipat,

Muangnoi

et al. 2023

Food Science & Nutrition

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The Impact of Aging on Multiple Sclerosis

Goyne,

Fair,

Sumowski

et al. 2024

Curr Neurol Neurosci Rep

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Telomere Length in Patients with Gestational Diabetes Mellitus and Normoglycemic Pregnant Women: a Systematic Review and Meta-analysis

Pérez‐López¹,

López‐Baena²,

Ulloque-Badaracco³

et al. 2023

Reprod. Sci.

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We performed a systematic review and meta-analysis of studies assessing telomere length in blood leukocytes or mononuclear cells in women with gestational diabetes mellitus (GDM) and normoglycemic pregnant women (NPW) and their infants. The review protocol was registered in PROSPERO (CRD42022300950). Searches were conducted in PubMed, Embase, LILACS, CNKI, and Wang Fang, from inception through November 2022. The primary outcomes were maternal and offspring telomere length. The Newcastle-Ottawa Scale was used to assess the quality of included studies. Random-effect meta-analyses were applied to estimate standardized mean differences (SMDs) and their 95% confidence interval (CI). The meta-analysis of four studies showed no significant maternal telomere length difference (SMD = −0.80, 95% CI: −1.66, 0.05) in women with GDM compared to NPW. In the sensibility analysis omitting one study with a small sample of women, the telomere length becomes significantly reduced in women with GDM (SMD = −1.10, 95% CI: −2.18, −0.02). GDM patients had increased glucose (SMD = 0.28, 95% CI: 0.09, 0.46) and glycosylated hemoglobin than NPW (SMD = 0.62, 95% CI: 0.23, 1.01) while total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides did not display differences between women with and without GDM. There was no significant difference in cord blood telomere length in offspring from women with GDM and NPW (SMD = 0.11, 95% CI: −0.52, 0.30). Cord blood insulin levels (SMD = 0.59, 95% CI: 0.33, 0.85) and birthweight (SMD = 0.59, 95% CI: 0.39, 0.79) were higher in offspring from pregnant women with GDM than in those from NPW. There were no significant differences in maternal and offspring telomere length between pregnancies with and without GDM.

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RETRACTED: Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis

Cited by 12 publications

References 72 publications

Efficacy of a dietary supplement derived from five edible plants on telomere length in Thai adults: A randomized, double‐blind, placebo‐controlled trial

Efficacy of a dietary supplement derived from five edible plants on telomere length in Thai adults: A randomized, double‐blind, placebo‐controlled trial

The Impact of Aging on Multiple Sclerosis

Telomere Length in Patients with Gestational Diabetes Mellitus and Normoglycemic Pregnant Women: a Systematic Review and Meta-analysis

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