Obesidad en mujeres chilenas en edad fértil

B, Marcela Araya; Padilla, Oslando; Garmendia, María Luisa; Atalah, Eduardo; Uauy, Ricardo

doi:10.4067/s0034-98872014001100011

Cited by 20 publications

(13 citation statements)

References 31 publications

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“…Another aspect observed in this study was the increase in weight of the women from the 6th month of pregnancy until the delivery (average 12.2 kg), in addition to the high prevalence of overweight and obese women at the end of pregnancy (62.8%), along with the birth weight of children, which, on average, was 4.25 kg. In this context, previous studies suggest that Chilean women during the fertile age show a fast and growing tendency towards obesity [ 41 ], and a high prevalence of being overweight (50%) and obese (20%) is observed in pregnant Chilean women [ 42 ]. This nutritional situation has been related to (i) the increasing tendency of the Chilean newborns to have a weight at birth higher than 4.0 kg [ 43 ] and (ii) a high number of births by caesarian intervention, which are associated with overweight and obesity of pregnant women (up to 35%) [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Maternal Diet during Pregnancy and Lactation on the Fatty Acid Composition of Erythrocytes and Breast Milk of Chilean Women

et al. 2018

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Maternal diet during pregnancy is relevant for fatty acid supply during fetal life and lactation. Arachidonic (AA) and docosahexaenoic (DHA) acids are also relevant for the normal growth and development of brain and visual system. AA and DHA provided by the mother to the fetus and infant are directly associated with maternal dietary intake and body stores. Our aim was to evaluate the impact of maternal diet, specially referring to the quality of fatty acid intake, in a sample of Chilean women during last stage of pregnancy and across the lactation period. Fifty healthy pregnant women (age range 20–33 years) were studied from the 6th month of pregnancy and followed until 6th month of lactation period. Diet characteristics were evaluated through food frequency questionnaires. Fatty acids composition of erythrocyte phospholipids and breast milk samples was assessed by gas-liquid chromatography. Overall, women had high saturated fatty acids intake with sufficient intake of mono- and polyunsaturated fatty acids (PUFA). Diet was high in n-6 PUFA and low in n-3 PUFA (mainly DHA), with imbalanced n-6/n-3 PUFA ratio. Erythrocytes and breast milk DHA concentration was significantly reduced during lactation compared to pregnancy, a pattern not observed for AA. We concluded that is necessary to increase the intake of n-3 PUFA during pregnancy and lactation by improving the quality of consumed foods with particular emphasis on its DHA content.

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Section: Discussionmentioning

confidence: 99%

The Impact of Maternal Diet during Pregnancy and Lactation on the Fatty Acid Composition of Erythrocytes and Breast Milk of Chilean Women

et al. 2018

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“…Maternal obesity during pregnancy and lactation is one of the most typical representatives of early-life overnutrition in humans. A significant volume of evidence have shown that the prevalence of obesity in women of childbearing ages is still growing rapidly, [ 30 , 31 ] which has been shown to increase the risks of metabolic disorders in offspring. [ 32 ] In the Helsinki Birth Cohort Study, Eriksson et al [ 33 ] reported that maternal body mass index (BMI) during pregnancy was positively associated with offspring health outcomes in later life, especially including cardiovascular disease and T2DM.…”

Section: Over-nutrition In Early Life and Energy Metabolism In Later mentioning

confidence: 99%

Early-life nutrition and metabolic disorders in later life: a new perspective on energy metabolism

Zhou

Deng

Zhang

et al. 2020

Chinese Medical Journal

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Type 2 diabetes mellitus and metabolic disorders have become an epidemic globally. However, the pathogenesis remains largely unclear and the prevention and treatment are still limited. In addition to environmental factors during adulthood, early life is the critical developmental window with high tissue plasticity, which might be modified by external environmental cues. Substantial evidence has demonstrated the vital role of early-life nutrition in programming the metabolic disorders in later life. In this review, we aim to overview the concepts of fetal programming and investigate the effects of early-life nutrition on energy metabolism in later life and the potential epigenetic mechanism. The related studies published on PubMed database up to March 2020 were included. The results showed that both maternal overnutrition and undernutrition increased the riskes of metabolic disorders in offspring and epigenetic modifications, including DNA methylation, miRNAs, and histone modification, might be the vital mediators. The beneficial effects of early-life lifestyle modifications as well as dietary and nutritional interventions on these deleterious metabolic remolding were initially observed. Overall, characterizing the early-life malnutrition that reshapes metabolic disease trajectories may yield novel targets for early prevention and intervention and provide a new point of view to the energy metabolism.

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“…VEN prevalence obtained from Instituto Nacional de Nutrición (2008–2010). CHI obesity prevalence obtained from Encuesta Nacional de Salud (ENS-2009) and reviewed in ( Araya et al, 2014 ). PAN obesity prevalence obtained from cross-sectional studies (2010–2011) ( Mc Donald et al, 2015 ).…”

Section: Prevalence Of Overweight and Obesity Among Women Of Reproducmentioning

confidence: 99%

Antioxidants and Oxidative Stress: Focus in Obese Pregnancies

Alcalá

Gutiérrez-Vega²,

Castro

et al. 2018

Front. Physiol.

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The prevalence of obesity in women of childbearing age around the globe has dramatically increased in the last decades. Obesity is characterized by a low-state chronic inflammation, metabolism impairment and oxidative stress, among other pathological changes. Getting pregnant in this situation involves that gestation will occur in an unhealthy environment, that can potentially jeopardize both maternal and fetal health. In this review, we analyze the role of maternal obesity-induced oxidative stress as a risk factor to develop adverse outcomes during gestation, including reduced fertility, spontaneous abortion, teratogenesis, preeclampsia, and intrauterine growth restriction. Evidences of macromolecule oxidation increase in reactive oxygen species generation and antioxidant defense alterations are commonly described in maternal and fetal tissues. Thus, antioxidant supplementation become an interesting prophylactic and therapeutic tool, that yields positive results in cellular, and animal models. However, the results from most meta-analysis studying the effect of these therapies in complicated gestations in humans are not really encouraging. It is still to be analyzed whether these therapies could work if applied to cohorts of patients at a high risk, such as those with low concentration of antioxidants or obese pregnant women.

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Obesidad en mujeres chilenas en edad fértil

Cited by 20 publications

References 31 publications

The Impact of Maternal Diet during Pregnancy and Lactation on the Fatty Acid Composition of Erythrocytes and Breast Milk of Chilean Women

The Impact of Maternal Diet during Pregnancy and Lactation on the Fatty Acid Composition of Erythrocytes and Breast Milk of Chilean Women

Early-life nutrition and metabolic disorders in later life: a new perspective on energy metabolism

Antioxidants and Oxidative Stress: Focus in Obese Pregnancies

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