Oat attenuate non-alcoholic fatty liver and obesity via inhibiting lipogenesis in high fat-fed rat

Peng, Chiung-Huei; Chang, Hong-Chou; Yang, Mon-Yuan; Huang, Chien‐Ning; Wang, Shing-Jung; Wang, Chau‐Jong

doi:10.1016/j.jff.2012.08.003

Cited by 32 publications

(21 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…; Peng et al . ). Thus, the decrease in activities of liver ALP, ALT and AST of high‐fat diet‐fed rats with corresponding increase in the serum indicates compromised hepatocellular integrity.…”

Section: Discussionmentioning

confidence: 97%

“…In addition to rapid weight gain associated with high-fat diets (Akbay et al 2004), dyslipidemia, oxidation of proteins and lipids, as well as DNA fragmentation have been reported Peng et al 2013). Changes in the lipid metabolism have been implicated in the pathogenesis of atherosclerosis and cardiovascular disease, which is characterized by elevated LDLc and TAGs and decreased HDLc (Hutcheson and Rocic 2012).…”

Section: Discussion Dyslipidemiamentioning

confidence: 99%

“…Hepatocellular enzymes such as ALP, ALT and AST have been shown to increase in the serum of high-fat diet-treated rats Peng et al 2013). Thus, the decrease in activities of liver ALP, ALT and AST of high-fat diet-fed rats with corresponding increase in the serum indicates compromised hepatocellular integrity.…”

Section: Hepatocellular Enzymesmentioning

confidence: 99%

See 2 more Smart Citations

Trichosanthes CucumerinaFruit Extenuates Dyslipidemia, Protein Oxidation, Lipid Peroxidation and DNA Fragmentation in the liver of high-fat diet-fed rats

Ajiboye

Akinpelu

Muritala

et al. 2014

Journal of Food Biochemistry

View full text Add to dashboard Cite

The effect of Trichosanthes cucumerina fruit pulp extract on dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in the liver of high‐fat diet‐fed rats was investigated. High‐fat diet‐mediated alterations in liver and serum total cholesterol, triacylglycerol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, very‐low‐density lipoprotein cholesterol, alkaline phosphatase, and alanine and aspartate aminotransferase were significantly (P < 0.05) reversed by the T. cucumerina pulp extract. The extract increased the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6‐phosphate dehydrogenase in the mitochondria and post‐mitochondria fractions of rat liver. The increase significantly (P < 0.05) attenuated high‐fat diet‐mediated reductions in antioxidant enzyme activities. High‐fat diet‐mediated elevation in the levels of conjugated dienes, lipid hydroperoxides, malondialdehyde, protein carbonyl and DNA fragmentation in rat liver was dose‐dependently lowered by the extract. The data obtained from this study showed that the T. cucumerina fruit pulp extract palliated high‐fat diet‐mediated dyslipidemia, protein oxidation, lipid peroxidation and DNA fragmentation in rats. Practical Applications Trichosanthes cucumerina fruit pulp can be developed into a nutraceutical product to treat liver disorders. It can also be consumed at home and as substitute to Lycopersicon esculentum (L.) Mill. The fruit pulp of T. cucumerina is sweet tasting, aromatic, deep red in color and does not go sour as quickly as paste of L. esculentum.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussion Dyslipidemiamentioning

confidence: 99%

See 1 more Smart Citation

Trichosanthes CucumerinaFruit Extenuates Dyslipidemia, Protein Oxidation, Lipid Peroxidation and DNA Fragmentation in the liver of high-fat diet-fed rats

Ajiboye

Akinpelu

Muritala

et al. 2014

Journal of Food Biochemistry

View full text Add to dashboard Cite

show abstract

“…Consistently, the risk for NAFLD has been shown to be negatively associated with an intake of vegetables [11,25], fruit [25], whole grains [26], and legumes [25]. In rats fed tomato [27], apricot [28], and oats [29], the accumulation of hepatic steatosis was suppressed by inhibiting lipogenesis and increasing lipolysis due to anti-oxidative mechanisms. The intake of vitamin E, a strong antioxidant, has been shown to be lower in Korean males with NAFLD compared to those without NAFLD [11].…”

Section: Discussionmentioning

confidence: 99%

Association of Blood Fatty Acid Composition and Dietary Pattern with the Risk of Non-Alcoholic Fatty Liver Disease in Patients Who Underwent Cholecystectomy

Shim¹,

Choi²,

Park³

2017

Ann Nutr Metab

View full text Add to dashboard Cite

Background/Aims: The relationship between diet and non-alcoholic fatty liver disease (NAFLD) in patients with gallstone disease and in those who have a high risk for NAFLD has not been investigated. This study was conducted to investigate the association between the risk of NAFLD and dietary pattern in patients who underwent cholecystectomy. Additionally, we assessed the association between erythrocyte fatty acid composition, a marker for diet, and the risk of NAFLD. Methods: Patients (n = 139) underwent liver ultrasonography to determine the presence of NAFLD before laparoscopic cholecystectomy, reported dietary intake using food frequency questionnaire, and were assessed for blood fatty acid composition. Results: Fifty-eight patients were diagnosed with NAFLD. The risk of NAFLD was negatively associated with 2 dietary patterns: consuming whole grain and legumes and consuming fish, vegetables, and fruit. NAFLD was positively associated with the consumption of refined grain, meat, processed meat, and fried foods. Additionally, the risk of NAFLD was positively associated with erythrocyte levels of 16:0 and 18:2t, while it was negatively associated with 20:5n3, 22:5n3, and Omega-3 Index. Conclusion: The risk of NAFLD was negatively associated with a healthy dietary pattern of consuming whole grains, legumes, vegetables, fish, and fruit and with an erythrocyte level of n-3 polyunsaturated fatty acids rich in fish.

show abstract

“…A similar trend in regulating fat distribution in rats was found for OATS. Diets enriched in whole oats (Peng et al, 2013) or oat β-glucan (Schroeder et al, 2013) have been reported to correlate with fat A B C deposition in rats. However, in these studies SCFAs that mediated the modulating activity of oats on fat metabolism, were not considered.…”

Section: Cereal β-Glucan and Arabinoxylans (Axs)mentioning

confidence: 99%

Influence of pectin supplementation on feed fermentation characteristics in rats and pigs

Tian¹

View full text Add to dashboard Cite

at 11 a.m. in the Aula. Lingmin TianInfluence of pectin supplementation on feed fermentation characteristics in rats and pigs 152 pages PhD thesis, Wageningen University, Wageningen, NL (2016) With references, with summary in English ISBN: 978-94-6257-728-2 AbstractThe physiological effects of dietary fiber (DFs) depend on several factors including structural features of the DFs, composition and activity of colonic microbiota, and products formed during fermentation. In this thesis, the influence of pectin supplementation to feed fermentation characteristics in rats and pigs was studied. The non-starch polysaccharides (NSP) present in the selected feed ingredient oats were characterized. Distinct populations of arabinoxylans (AXs) were observed in oats, compared to those reported for other cereals like wheat and barley. The fate of cereal AXs and soybean pectin during fermentation and the consequent effects on appetite regulation and fat accumulation were studied in rats as a model. Oat AXs were fermented less rapidly than wheat AXs in the caecum of rats. Soy pectin was fermented more early and efficiently than cereal AXs. A significant inverse correlation between rat retroperitoneal fat-pad weight and concentration and relative SCFA proportion of butyrate was observed. In a following in vivo rat experiment, commercial soy pectin together with three other soluble pectins originating from citrus and sugar beet and differing in their methyl esterification were individually supplemented to the diets. Their effects on the utilization of the different DFs present in the feed and the consequent effect on the microbial community in the colon of rats was studied. All pectins were fermented rapidly and consequently shifted fermentation of other consumed DFs (e.g. cereal AXs) to more distal part of colon, although low-methyl esterified pectin was more efficiently fermented by the microbiota than high-methyl esterified pectin. Results suggested that pectins can confer beneficial health effects through modulation of the gut microbiota. In a last in vivo experiment, citrus pectins together with a hydrothermal treated soybean meal were supplemented to pig diets to study their effect on the digestion and fermentation of carbohydrates in both the small and large intestine. Pectins, and more particularly lowmethyl esterified pectin, decreased the ileal digestibility of digestible starch resulting in more starch to be fermentated in the proximal colon of pigs. Consequently, also the fermentation patterns of DFs and the microbiota composition was affected. All pectins tested shaped the colonic microbiota from a Lactobacillus-dominated microbiota to a Prevotella-dominated community, with potential health-promoting effects.

show abstract

Oat attenuate non-alcoholic fatty liver and obesity via inhibiting lipogenesis in high fat-fed rat

Cited by 32 publications

References 25 publications

Trichosanthes CucumerinaFruit Extenuates Dyslipidemia, Protein Oxidation, Lipid Peroxidation and DNA Fragmentation in the liver of high-fat diet-fed rats

Trichosanthes CucumerinaFruit Extenuates Dyslipidemia, Protein Oxidation, Lipid Peroxidation and DNA Fragmentation in the liver of high-fat diet-fed rats

Association of Blood Fatty Acid Composition and Dietary Pattern with the Risk of Non-Alcoholic Fatty Liver Disease in Patients Who Underwent Cholecystectomy

Influence of pectin supplementation on feed fermentation characteristics in rats and pigs

Contact Info

Product

Resources

About