O89 – 1600 Language development at 2 years is correlated to brain microstructure in the left superior temporal gyrus at term equivalent age: a diffusion tensor imaging study

Aeby, Alec; Tiège, Xavier De; David, Patrizia; Balériaux, Danielle; Overmeire, Bart Van; Metens, Thierry; Bogaert, Pierre-Paul Van

doi:10.1016/s1090-3798(13)70091-6

Cited by 3 publications

(3 citation statements)

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“…Our results are in agreement with previous works that found a link between left perisylvian morphology and language development in high-risk infants, such as in newborns suffering from hypoxic-ischemic injury [26] or preterm infants [27] . In CHD, white matter volume was found to correlate with language development, but not broader developmental indices [28] , similarly to our measurements, and in concordance with studies on extremely preterm infants [29] .…”

Section: Discussionsupporting

confidence: 93%

Left temporal plane growth predicts language development in newborns with congenital heart disease

Jakab

Meuwly

Feldmann

et al. 2019

Brain

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on behalf of the Research Group Heart and BrainCongenital heart diseases (CHD) are the most common congenital anomalies, accounting for a third of all congenital anomaly cases. While surgical correction dramatically improved survival rates, the lag behind normal neurodevelopment appears to persist. Deficits of higher cognitive functions are particularly common, including developmental delay in communication and oral-motor apraxia. It remains unclear whether the varying degree of cognitive developmental delay is reflected in variability in brain growth patterns. To answer this question, we aimed to investigate whether the rate of regional brain growth is correlated with later life neurodevelopment. 44 newborns were included in our study, out of whom 33 were diagnosed with dextrotransposition of the great arteries (d-TGA) and 11 with other forms of severe CHD. During the first month of life, neonates underwent corrective or palliative cardiovascular bypass surgery, pre-and postoperative cerebral MRI were performed 18.7 ± 7.03 days apart. MRI was performed in natural sleep on a 3.0T scanner using an 8-channel head coil, fast spin-echo T2weighted anatomical sequences were acquired in three planes. Based on the principles of deformation based morphometry, we calculated brain growth rate maps that reflected the rate of non-linear deformation that occurs between pre-and postoperative brain images. An explorative, whole-brain, threshold-free cluster enhancement analysis revealed strong correlation between the growth rate of the left planum temporale and the posterior operculum of the left frontal lobe and language score at 12 months of age, corrected for demographic variables (p=0.018, t=5.656). No significant correlation was found between brain growth rates and motor or cognitive scores. Post hoc analysis showed that the length of hospitalization interacts with this correlation with longer hospitalization stay results in faster enlargement of the internal cerebro-spinal fluid spaces. Our study provides evidence to the early importance of left-dominant perisylvian regions in language development even before the direct postnatatal exposure to native language. In CHD patients, the perioperative period results in a critical variability of brain growth rate in this region, which is a reliable neural correlate of language development at one year of age.

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Section: Discussionsupporting

confidence: 93%

Left temporal plane growth predicts language development in newborns with congenital heart disease

Jakab

Meuwly

Feldmann

et al. 2019

Brain

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“…Together with its receptor ERBB4 (also discussed above), NRG1 is involved in the enhancement of synchronized oscillations in the prefrontal cortex, known to be reduced in SZ (Fisahn et al 2009, Hou et al 2014. Risk polymorphisms of NRG1 are associated with language performance in people with bipolar disorder (Rolstad et al 2015) and correlate with reduced volumes of the left superior temporal gyrus (a robust imaging finding in SZ) (Tosato et al 2012), a region involved in language processing (Aeby et al 2013). Concerning NRG3¸ it is known to influence prefrontal cortex activation during working memory performance (Tost et al 2014).…”

Section: Common Candidates For Sz Asd and Language Evolution: A Funcmentioning

confidence: 99%

Language deficits in schizophrenia and autism as related oscillatory connectomopathies: An evolutionary account

Murphy

Benítez‐Burraco

2017

Neuroscience & Biobehavioral Reviews

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Schizophrenia (SZ) and autism spectrum disorders (ASD) are characterised by marked language deficits, but it is not clear how these arise from gene mutations associated with the disorders. Our goal is to narrow the gap between SZ and ASD and, ultimately, give support to the view that they represent abnormal (but related) ontogenetic itineraries for the human faculty of language. We will focus on the distinctive oscillatory profiles of the SZ and ASD brains, in turn using these insights to refine our understanding of how the brain implements linguistic computations by exploring a novel model of linguistic feature-set composition. We will argue that brain rhythms constitute the best route to interpreting language deficits in both conditions and mapping them to neural dysfunction and risk alleles of the genes. Importantly, candidate genes for SZ and ASD are overrepresented among the gene sets believed to be important for language evolution. This translational effort may help develop an understanding of the aetiology of SZ and ASD and their high prevalence among modern populations.

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“…[15][16][17] Abnormalities in such functions are common in disorders with social impairment, including ASD. [18][19][20] PAC is a primary sensory cortex that modulates auditory processing, a function not usually associated with ASD impairments. Structurally, these regions exhibit distinct patterns of cellular and neurochemical organization.…”

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confidence: 99%

Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains

Stamova

Ander

Barger³

et al. 2015

J Child Neurol

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Small noncoding RNAs play a critical role in regulating messenger RNA throughout brain development and when altered could have profound effects leading to disorders such as autism spectrum disorders (ASD). We assessed small noncoding RNAs, including microRNA and small nucleolar RNA, in superior temporal sulcus association cortex and primary auditory cortex in typical and ASD brains from early childhood to adulthood. Typical small noncoding RNA expression profiles were less distinct in ASD, both between regions and changes with age. Typical micro-RNA coexpression associations were absent in ASD brains. miR-132, miR-103, and miR-320 micro-RNAs were dysregulated in ASD and have previously been associated with autism spectrum disorders. These diminished region- and age-related micro-RNA expression profiles are in line with previously reported findings of attenuated messenger RNA and long noncoding RNA in ASD brain. This study demonstrates alterations in superior temporal sulcus in ASD, a region implicated in social impairment, and is the first to demonstrate molecular alterations in the primary auditory cortex.

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O89 – 1600 Language development at 2 years is correlated to brain microstructure in the left superior temporal gyrus at term equivalent age: a diffusion tensor imaging study

Cited by 3 publications

References 0 publications

Left temporal plane growth predicts language development in newborns with congenital heart disease

Left temporal plane growth predicts language development in newborns with congenital heart disease

Language deficits in schizophrenia and autism as related oscillatory connectomopathies: An evolutionary account

Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains

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