The implementation of TB control programs (TCP) in the municipal context demands the recognition of its many peculiarities, which may help to understand the factors involved in achieving the goals set by TB policies. This is an ecological study, descriptive and exploratory, whose objectives were to evaluate the performance of TCPs in cities of São Paulo state (SP) in 2010. We included in the study municipalities with more than 20,000 inhabitants and minimum 5 confirmed TB cases, out of the prison system, residents and reported in the year of study. Data analysis was carried out in three stages, namely: verification of the data completeness obtained in the local reporting TB system (TBWEB), calculation of operational indicators from data which presented regular to satisfactory completeness and application of multivariate analysis techniques. We used cluster analysis (CA) to identify municipalities with similar profiles regarding the TB control performance according to the operational indicators, and, from the identified groups, multiple correspondence analysis (MCA) was used to verify their association with demographic characteristics, issues related to health systems and epidemiological situation of TB and AIDS. The database used for the study presented a good completeness evaluation in most of the variables considered. Regarding the formation of groups and their association with epidemiological, demographic and health services characteristics, we identified 3 groups: a poor performance group composed of 63 municipalities (32.3%), with the lowest cure rate and a highest dropout rate, a lower proportion of patients referred to DOT followed by a lower proportion of supervision, and lower performance of HIV testing and few examined contacts among those identified. MCA identified an association between this group and high coinfection TBHIV, low to medium TB incidence and located in the countryside, with higher coverage of health family-based strategies. The satisfactory group composed of 89 municipalities (45.6%) had the highest proportion of patients DOT indication and completion, with the best outcome indicators and the highest HIV testing proportions and contacts evaluation. The regular performance group was composed of 43 municipalities (22.1%) and was identified by a lower DOT indication and completion, however, with outcome indicators and HIV testing and contacts evaluation closer to the satisfactory group. These two groups were associated with cities with high TB incidence and medium AIDS incidence and a moderate TBHIV co-infection, located in the metropolitan area and the coast, with lower coverage of health family-based strategies.. The TCP coordinators need to use technical, administrative, and political abilities, in order to negotiate with the macro-management and provide the best resources for micro-management implement the planned activities. La implementación de programas de control de TB (PCT) en el contexto municipal implica el reconocimiento de sus peculiaridades, que pueden ayudar a comprender los...