O<scp>ral</scp> S<scp>equelae of</scp> H<scp>ead and</scp> N<scp>eck</scp> R<scp>adiotherapy</scp>

Vissink, Arjan; Jansma, J.; Spijkervet, Frederik; Burlage, Fred R.; Coppes, Robert P.

doi:10.1177/154411130301400305

Cited by 761 publications

(614 citation statements)

References 166 publications

(307 reference statements)

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“…Hyposalivation is a common acute and long-term complication of antineoplastic therapies of head and neck. 8,30 In HSCT-treated patients, radiotherapy is likely to be one etiological factor for hyposalivation. 9 Hypofunction of salivary glands depends on the cumulative dose to the gland tissue, and exposure to high total radiation doses (426-36 Gy) leads to a significant reduction of salivary secretion.…”

Section: Discussionmentioning

confidence: 99%

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Daikeler

Mauramo

Rovó

et al. 2013

Bone Marrow Transplant

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The objective of this prospective cross-sectional case-control study was to examine the prevalence of dryness symptoms and its impact on quality of life (QoL) among very long-term survivors after hematopoietic SCT (HSCT) in comparison with their respective sibling donors. Forty-four allogeneic HSCT recipients with a long-term survival (median: 17.5; range: 11-26 years) were included. Their respective, HLA-identical sibling donors served as controls. Clinical examinations included saliva flow rates (SFR) and the Schirmer's test. The presence of sicca symptoms of mouth, eyes and skin were inquired. The social functioning (SF)-36 questionnaire was applied. Recipients had lower (Po0.01) unstimulated and stimulated mean SFR than donors. Schirmer's test results o5 mm was found in 45% of the recipients in comparison with 27% of the donors (P ¼ 0.07). Xerostomia (34 vs 4 subjects), xerophtalmia (23 vs 3) and dry skin (32 vs 12) were reported more often by the recipients than donors (Po0.001). Sicca symptoms and their objective findings correlated with QoL. The mean SF-36 scores of the donors were significantly higher than those of the recipients for physical component summary. In conclusion, sicca symptoms are common amongst long-term survivors of HSCT and affect remarkably the QoL.

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Section: Discussionmentioning

confidence: 99%

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Daikeler

Mauramo

Rovó

et al. 2013

Bone Marrow Transplant

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“…Exposure of the salivary gland to radiation often results in a progressive loss of gland function within the first weeks of radiotherapy (1). The reduction in saliva flow rate and alteration of salivary composition may persist during the rest of the patient's life, leading to complications, including oral dryness, nocturnal oral discomfort, increased risk for oral infections, dental caries, and difficulties in speech, which severely hamper the quality of life (2,3).…”

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confidence: 99%

Mobilization of Bone Marrow Stem Cells by Granulocyte Colony-Stimulating Factor Ameliorates Radiation-Induced Damage to Salivary Glands

Lombaert¹,

Wierenga²,

Kok³

et al. 2006

Clinical Cancer Research

141

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Purpose: One of the major reasons for failure of radiotherapeutic cancer treatment is the limitation in dose that can be applied to the tumor because of coirradiation of the normal healthy tissue. Late radiation-induced damage reduces the quality of life of the patient and may even be life threatening. Replacement of the radiation-sterilized stem cells with unirradiated autologous stem cells may restore the tissue function. Here, we assessed the potential of granulocyte colony-stimulating factor (G-CSF)–mobilized bone marrow–derived cells (BMC) to regenerate and functionally restore irradiated salivary glands used as a model for normal tissue damage. Experimental Design: Male-eGFP+ bone marrow chimeric female C57BL/6 mice were treated with G-CSF, 10 to 60 days after local salivary gland irradiation. Four months after irradiation, salivary gland morphology and flow rate were assessed. Results: G-CSF treatment induced homing of large number of labeled BMCs to the submandibular glands after irradiation. These animals showed significant increased gland weight, number of acinar cells, and salivary flow rates. Donor cells expressed surface markers specific for hematopoietic or endothelial/mesenchymal cells. However, salivary gland acinar cells neither express the G-CSF receptor nor contained the GFP/Y chromosome donor cell label. Conclusions: The results show that BMCs home to damaged salivary glands after mobilization and induce repair processes, which improve function and morphology. This process does not involve transdifferentiation of BMCs to salivary gland cells. Mobilization of BMCs could become a promising modality to ameliorate radiation-induced complications after radiotherapy.

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“…Therefore, among the many healthy problems encountered after radiation therapy there are a few that may interfere directly with the quality of life as showed in Table 5. Alterations of taste sensation occurs as a result of the direct effect of radiation on the taste buds and due to change in the saliva [21] [25]. In most instances, tastes returns gradually to normal or near normal levels in the first year after therapy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Quality of Life Related to I-131 Therapy in Patients with Well-Differentiated Thyroid Cancer and Emphasis in Salivary Morbidity: A Follow up Study after Treatment

Corrêa¹,

Moriguchi²,

Boldrini³

et al. 2014

ABB

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Goal: To evaluate the impact of iodine-131 therapy received during childhood and adolescence and correlate it with the quality of life in these patients. Methods: We studied 19 patients diagnosed with cancer in childhood or adolescence who underwent thyroidectomy and supplemental therapy with I-131. We also recruited a control group of healthy subjects with the same demographic parameters. All patients were subjected to a scintigraphy examination of the salivary glands, and were also asked to complete a questionnaire in order to assess their overall quality of life. In addition, a more specific questionnaire for patients with head and neck cancer was also given to all study participants. Results: The quantitative and qualitative analyses of the salivary glands showed functional deficits with greater involvement of the parotid gland for volume, concentration and excretion. The right submandibular gland showed significant changes for volume in the patient group. The questionnaires made it possible to observe significant differences between the patient and control groups for symptoms such as thick saliva, dry mouth and speech problems. Conclusion: In spite of being very effective and widely used, iodine radionuclide therapy * Corresponding author. L. G. Corrêa et al. 410is correlated with a lower quality of life in young people.

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Oral Sequelae of Head and Neck Radiotherapy

Cited by 761 publications

References 166 publications

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Mobilization of Bone Marrow Stem Cells by Granulocyte Colony-Stimulating Factor Ameliorates Radiation-Induced Damage to Salivary Glands

Evaluation of Quality of Life Related to I-131 Therapy in Patients with Well-Differentiated Thyroid Cancer and Emphasis in Salivary Morbidity: A Follow up Study after Treatment

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