From Chester, Matthew Henry moved to Hackney (then on the northern border of London) for the final two years of his life and ministry. As a leading dissenter, he was immediately called to preach extensively beyond his congregation. In addition, he was working on his Exposition and publishing sermons. But various challenges faced him, in particular ill-health and tensions within his family. As at Chester, he had no formal elders or deacons to assist him. His extant diary from 1705 to 1713 gives a detailed account of his ministry. He displayed the Puritan ideal of a pastor/preacher, together with involvement in other dissenting interests. His ministry shows his deep devotion to New Testament teaching on the role of shepherding God’s flock. KEYWORDS: Puritans, Matthew Henry, dissenters, non-conformists, Chester, commentaries, Hackney, Puritan spirituality