Nystatin nanosizing enhances in vitro and in vivo antifungal activity against Candida albicans

Melkoumov, Alexandre; Goupil, Mathieu; Louhichi, Fatiha; Raymond, Martine; Repentigny, Louis de; Leclair, Grégoire

doi:10.1093/jac/dkt137

Cited by 42 publications

(23 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the risk of dental caries is increased because of its sucrose content. Some novel approaches that have been proposed to increase the efficacy of nystatin include nanonsisation. On the other hand, nystatin and amphotericin B (polyene antifungals) show negligible absorption from the gastrointestinal tract and are widely used for the topical treatment of oral candidiasis.…”

Section: Discussionmentioning

confidence: 99%

Antifungal prescribing pattern and attitude towards the treatment of oral candidiasis among dentists in Jordan

Al-Shayyab

Abu‐Hammad

AL‐Omiri

et al. 2015

International Dental Journal

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Antifungal prescribing pattern and attitude towards the treatment of oral candidiasis among dentists in Jordan

Al-Shayyab

Abu‐Hammad

AL‐Omiri

et al. 2015

International Dental Journal

View full text Add to dashboard Cite

show abstract

“…Discovered in the 1950s, by the New York State Health Laboratory, it was the fi rst effective treatment for the cure of oral candidosis (Giannini and Shetty 2011 ;Melkoumov et al 2013 ;Muzyka and Glick 1995 ;Vazquez 2010 ;Pappas et al 2009 ;Park and Kang 2011 ;Klotz 2006 ;Neville et al 2002 ;Greenspan 1994 ). Derived from Streptomyces noursei culture, this macrolide resembles in its structure the amphotericin B.…”

Section: Nystatinmentioning

confidence: 99%

“…If the patient is using intraoral devices such as dentures, they must be removed during the application of the drug. The treatment has a variable duration of 7-14 days, continuing for 2-3 days after the disappearance of clinical signs and symptoms of the infection (Li et al 2014 ;Melkoumov et al 2013 ).…”

mentioning

confidence: 99%

Antifungals for Candidosis Treatment

et al. 2015

View full text Add to dashboard Cite

The available treatments for oral candidosis have proved to be more effi cacious with the use of new and known antifungal drugs. The success of these is directly related to the correct diagnosis, identifi cation, and correction of etiological factors and the commitment of the patient. In the absence of some of these factors, the antifungal therapy results only in a brief relief from disease, triggering relapses. This chapter presents the main drugs used in the treatment of oral and oropharyngeal candidosis, their functioning in the human body, and their mechanism of action in the destruction of the pathogenic agent.

show abstract

“…Nevertheless, still, only 15 agents are approved for clinical use at present [6], [7]. The most common human fungal infection is oral candidiasis (also called oral thrush), which is characterized by an overgrowth of Candida species in the superficial epithelium of the oral mucosa [8], [9]. Treatment for oral thrush varies, polyenes, allylamines, and azoles are three classes of antifungal agents that used most frequently for treatments of oral thrush [10].…”

Section: Introductionmentioning

confidence: 99%

Current Antifungal Drug Prescribing to Treat Oral Thrush in Sulaimani City-Iraq

Rsaul

2018

UHD J SCI TECH

View full text Add to dashboard Cite

Oral thrush or oral candidosis is one of the most widespread fungal infections of the mucous membranes in human. This study aims to evaluate the pattern of prescribing of three antifungal drugs: nystatin, amphotericin B, fluconazole, and miconazole by the pharmacists and assistant pharmacists, which are used to treat oral thrush. A questionnaire was circulated to a random selection of pharmacies in Sulaimani city of Iraq between March 2017 and June 2017 and responses to were received from 101 pharmacies. The results were analyzed and the responses demonstrated as absolute and relative frequencies using Statistical Package for the Social Sciences Program (SPSS) version 21. Among the participants (65.3%) were males and (34.7%) were females. The participant's age range was (20 – 70) years. The majority (52.3%) holds a postgraduate degree as their highest educational level and they graduated after 2010. Miconazole and nystatin were the most popular choices of an antifungal agent that pharmacists would use, followed by fluconazole and amphotericin-B. The possibility of using miconazole was positively linked to recently graduated participants.

show abstract

Nystatin nanosizing enhances in vitro and in vivo antifungal activity against Candida albicans

Abstract: Taken together, these data reveal that nanonization of nystatin provides a novel approach to enhancing its efficacy in the treatment of oral candidiasis.

Cited by 42 publications

References 38 publications

Antifungal prescribing pattern and attitude towards the treatment of oral candidiasis among dentists in Jordan

Antifungal prescribing pattern and attitude towards the treatment of oral candidiasis among dentists in Jordan

Antifungals for Candidosis Treatment

Current Antifungal Drug Prescribing to Treat Oral Thrush in Sulaimani City-Iraq

Contact Info

Product

Resources

About