Nutritional supplements for age-related macular degeneration

Krishnadev, Nupura; Meleth, Annal D.; Chew, Emily Y.

doi:10.1097/icu.0b013e32833866ee

Cited by 99 publications

(56 citation statements)

References 37 publications

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“…High intake of foods providing zeaxanthin is related with lower incidence of age-related macular degeneration (ARMD), mostly for ocular and retinal health. They are used as supplemental antioxidants in treating ARMD (37). The presence of this bacterium, which produces beta-carotene, in a clinical isolate in the context of CF was unexpected, and the role this bacterium may play in the lung microbiota remains to be studied in the future.…”

Section: Discussionmentioning

confidence: 99%

Whole-Genome Sequence of Chryseobacterium oranimense, a Colistin-Resistant Bacterium Isolated from a Cystic Fibrosis Patient in France

Sharma

Gupta

Diène

et al. 2015

Antimicrob Agents Chemother

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For the first time, we report the whole-genome sequence analysis of Chryseobacterium oranimense G311, a multidrug-resistant bacterium, from a cystic fibrosis patient in France, including resistance to colistin. Whole-genome sequencing of C. oranimense G311 was performed using Ion Torrent PGM, and RAST, the EMBL-EBI server, and the Antibiotic Resistance Gene-ANNOTation (ARG-ANNOT) database were used for annotation of all genes, including antibiotic resistance (AR) genes. General features of the C. oranimense G311 draft genome were compared to the other available genomes of Chryseobacterium gleum and Chryseobacterium sp. strain CF314. C. oranimense G311 was found to be resistant to all ␤-lactams, including imipenem, and to colistin. The genome size of C. oranimense G311 is 4,457,049 bp in length, with 37.70% GC content. We found 27 AR genes in the genome, including ␤-lactamase genes which showed little similarity to the known ␤-lactamase genes and could likely be novel. We found the type I polyketide synthase operon followed by a zeaxanthin glycosyltransferase gene in the genome, which could impart the yellow pigmentation of the isolate. We located the O-antigen biosynthesis cluster, and we also discovered a novel capsular polysaccharide biosynthesis cluster. We also found known mutations in the orthologs of the pmrA (E8D), pmrB (L208F and P360Q), and lpxA (G68D) genes. We speculate that the presence of the capsular cluster and mutations in these genes could explain the resistance of this bacterium to colistin. We demonstrate that whole-genome sequencing was successfully applied to decipher the resistome of a multidrug resistance bacterium associated with cystic fibrosis patients. Cystic fibrosis (CF) is the most common autosomal recessive genetic disease and results from mutations within the gene coding for the cystic fibrosis transmembrane regulator (CFTR) protein. This life-threatening disease affects all racial and ethnic groups, though it is more common among Caucasians (1, 2). CF is characterized by hyperproduction of viscous mucus by the affected glands, resulting mainly in impaired respiratory and pancreatic functions. The most common complication of CF involves the chronic respiratory infections caused by bacterial pathogens (3), which are the main reason for the high morbidity and mortality of the disease (4). Traditionally, only a few bacteria were involved in CF lung infections, including Staphylococcus aureus, Pseudomonas aeruginosa, Haemophilus influenzae, and Streptococcus pneumoniae. However, many new or emerging opportunistic bacteria have been described in CF patients over the past decade, for instance, Burkholderia cepacia complex, Stenotrophomonas maltophilia, Achromobacter xylosoxidans, Pandoraea spp., Ralstonia spp., Inquilinus limosus, and nontuberculosis mycobacteria, as well as fungi (5). Chronic microbial infection, along with P. aeruginosa infections, leads to excessive airway inflammation and the eventual loss of pulmonary function. Colistin is an extremely important antibiotic used in ...

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Section: Discussionmentioning

confidence: 99%

Whole-Genome Sequence of Chryseobacterium oranimense, a Colistin-Resistant Bacterium Isolated from a Cystic Fibrosis Patient in France

Sharma

Gupta

Diène

et al. 2015

Antimicrob Agents Chemother

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“…Several mouse models illustrate the capacity of oxidative damage to induce AMD-like pathology (21). Furthermore, one of the known interventions that can reduce AMD progression is consumption of antioxidants (22). Under normal physiological conditions, cells that undergo apoptosis due to oxidative stress are rapidly cleared by tissue resident phagocytic cells and the proinflammatory response is kept at a minimum.…”

Section: Discussionmentioning

confidence: 99%

JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration

Sun

Gumá

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Age-related macular degeneration (AMD) is the leading cause of registered blindness among the elderly and affects over 30 million people worldwide. It is well established that oxidative stress, inflammation, and apoptosis play critical roles in pathogenesis of AMD. In advanced wet AMD, although, most of the severe vision loss is due to bleeding and exudation of choroidal neovascularization (CNV), and it is well known that vascular endothelial growth factor (VEGF) plays a pivotal role in the growth of the abnormal blood vessels. VEGF suppression therapy improves visual acuity in AMD patients. However, there are unresolved issues, including safety and cost. Here we show that mice lacking c-Jun N-terminal kinase 1 (JNK1) exhibit decreased inflammation, reduced CNV, lower levels of choroidal VEGF, and impaired choroidal macrophage recruitment in a murine model of wet AMD (laser-induced CNV). Interestingly, we also detected a substantial reduction in choroidal apoptosis of JNK1-deficient mice. Intravitreal injection of a pan-caspase inhibitor reduced neovascularization in the laserinduced CNV model, suggesting that apoptosis plays a role in laserinduced pathological angiogenesis. Intravitreal injection of a specific JNK inhibitor decreased choroidal VEGF expression and reduced pathological CNV. These results suggest that JNK1 plays a key role in linking oxidative stress, inflammation, macrophage recruitment apoptosis, and VEGF production in wet AMD and pharmacological JNK inhibition offers a unique and alternative avenue for prevention and treatment of AMD.

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“…Preliminary phytochemical investigation of methanolic extract revealed the presence of alkaloid, acetogenin, flavonoids, stenoid and triterpenoids in A. reticulata (Krishnadev et al, 2010). Previous studies reported that alkaloid is responsible for the paralysis of earthworm.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Efficacy of Medicinal Plant Material on the Inhibition of Development of Egg of Ascaridia galli

Hossain¹

2015

J. adv. parasitol.

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| To determine the in vitro efficacy of indigenous plants on the inhibition of development of eggs of Ascaridia galli, a study was carried out in the laboratory of Department of Parasitology from January to May, 2012. Leaves of five plants namely pineapple (Ananas comosus), turmeric (Curcuma domestica), akanda (Calotropis gigantea), garlic (Allium sativum) and custard apple (Annona reticulata) were selected. Two different types of preparation such as fresh juice and dust material were used. Fresh leaves juice at 5%, 10% and 20% concentration and dust of leaves at 5%, 10% and 20% concentration were used for screening. Among the selected plants in all three concentrations of fresh juice of leaves, pineapple was the highest effective plant (86.9%) at 20% concentration followed by pineapple at 10% concentration (84.0%), garlic at 5% concentration (81.8%), turmeric at 20% concentration (78.9%), pineapple at 5% concentration (78.9%), turmeric at 10% concentration (73.9%), garlic at 10% concentration (73.0%). Among the plants in all concentrations of dust of leaves, pineapple at 20% concentration (76.9%) was observed as the best plant followed by akanda at 5% concentration (75.0%) and turmeric at 20% concentration (73.3%). The present study suggests that pineapple, turmeric and garlic leaves are effective and can be used against the development of eggs of A. galli. So, further studies are required to determine the side effects of these plants and determine the recommended doses in poultry.

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Nutritional supplements for age-related macular degeneration

Cited by 99 publications

References 37 publications

Whole-Genome Sequence of Chryseobacterium oranimense, a Colistin-Resistant Bacterium Isolated from a Cystic Fibrosis Patient in France

Whole-Genome Sequence of Chryseobacterium oranimense, a Colistin-Resistant Bacterium Isolated from a Cystic Fibrosis Patient in France

JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration

In Vitro Efficacy of Medicinal Plant Material on the Inhibition of Development of Egg of Ascaridia galli

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