Nutritional supplementation in chronic liver disease: An analytical review

Nompleggi, Dominic J.; Bonkovsky, Herbert L.

doi:10.1002/hep.1840190234

Cited by 130 publications

(81 citation statements)

References 51 publications

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“…Alcoholic patients have a high prevalence of protein-calorie malnutrition and vitamin deficiencies [20,21]. In our study a significant decrease was observed in food ingestion and body weight among the alcohol-consuming mice.…”

Section: Discussionsupporting

confidence: 57%

Effect of resveratrol on alcohol-induced mortality and liver lesions in mice

et al. 2006

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Section: Discussionsupporting

confidence: 57%

Effect of resveratrol on alcohol-induced mortality and liver lesions in mice

et al. 2006

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“…However, many more patients will have subtle changes such as fat-soluble vitamin defi ciencies, anemia from iron, folate, and pyridoxine defi ciency, altered cell-mediated immune function, and slow loss of muscle mass. [1][2][3][4] …”

mentioning

confidence: 98%

Nutritional management of acute and chronic liver disease

Saraf

2008

Hep B Annual

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Malnutrition is prevalent in all forms of liver diseases. A number of factors contribute to malnutrition in patients with hepatic failure. Early diagnosis of malnutrition is essential to allow appropriate treatment, since malnutrition is an important predictor of complications of liver disease and mortality. Disease-specifi c nutritional therapy should be considered for acute liver failure, sepsis, transplantation, and encephalopathy. This article provides an overview of the nutritional management of acute and chronic liver disease and discusses the need for further intervention studies before appropriate rational treatment guidelines can be formulated.

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“…This may have been because patients with a more severe liver disease are generally malnourished and emaciated[12] and have a lower BSA. Since, ESLD is associated with excessive bleeding due to portal hypertension[13] and abnormalities of hemostatic system,[1415] these may necessitate excessive transfusion of blood components.…”

Section: Discussionmentioning

confidence: 99%

Preoperative predictors of blood component transfusion in living donor liver transplantation

Makroo

Walia

Aneja

et al. 2013

Asian J Transfus Sci

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Context:Extensive bleeding associated with liver transplantation is a major challenge faced by transplant surgeons, worldwide.Aims:To evaluate the blood component consumption and determine preoperative factors that predict the same in living donor liver transplantation (LDLT).Settings and Design:This prospective study was performed for a 1 year period, from March 2010 to February 2011.Materials and Methods:Intra- and postoperative utilization of blood components in 152 patients undergoing LDLT was evaluated and preoperative patient parameters like age, gender, height, weight, disease etiology, hemoglobin (Hb), hematocrit (Hct), platelet count (Plt), total leukocyte count (TLC), activated partial thromboplastin time (aPTT), international normalized ratio (INR), serum bilirubin (T. bilirubin), total proteins (T. proteins), albumin to globulin ratio (A/G ratio), serum creatinine (S. creatinine), blood urea (B. urea), and serum electrolytes were assessed to determine their predictive values. Univariate and stepwise discriminant analysis identified those factors, which could predict the consumption of each blood component.Results:The average utilization of packed red cells (PRCs), cryoprecipitates (cryo), apheresis platelets, and fresh frozen plasma was 8.48 units, 2.19 units, 0.93 units, and 2,025 ml, respectively. Disease etiology and blood component consumption were significantly correlated. Separate prediction models which could predict consumption of each blood component in intra and postoperative phase of LDLT were derived from among the preoperative Hb, Hct, model for end-stage liver disease (MELD) score, body surface area (BSA), Plt, T. proteins, S. creatinine, B. urea, INR, and serum sodium and chloride.Conclusions:Preoperative variables can effectively predict the blood component requirements during liver transplantation, thereby allowing blood transfusion services in being better prepared for surgical procedure.

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Nutritional supplementation in chronic liver disease: An analytical review

Cited by 130 publications

References 51 publications

Effect of resveratrol on alcohol-induced mortality and liver lesions in mice

Effect of resveratrol on alcohol-induced mortality and liver lesions in mice

Nutritional management of acute and chronic liver disease

Preoperative predictors of blood component transfusion in living donor liver transplantation

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