Preoperative predictors of blood component transfusion in living donor liver transplantation

Makroo, Raj Nath; Walia, Rimpreet; Aneja, Sanjeev; Bhatia, Aakanksha; Chowdhry, Mohit

doi:10.4103/0973-6247.115586

Cited by 13 publications

(14 citation statements)

References 23 publications

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“…Lower rates of anti-HCV antibodies have also been reported in blood donors of Turkey (0.07%), Saudi Arabia (0.4%), Mexico (0.84%) and Kenya (0.9%) 10 . HCV is globally distributed, with anti-HCV prevalence among donors ranging from 0.3 to 0.5% throughout the world 1 .…”

Section: Resultsmentioning

confidence: 98%

“…Makroo et al 10 (2013) noted seroprevalence of anti-HCV antibodies in male blood donors was 0.38 per cent (n=750) while in female blood donors it was 0.36 per cent. In our study female donors (1.64%) showed high seroprevalence of anti-HCV antibodies compared to males (1.48%).…”

Section: Resultsmentioning

confidence: 99%

“…The reported variation in the prevalence of anti-HCV antibodies among blood donors in different regions of the world may be attributed to the differences in the type, literacy rate and level of awareness among the blood donors 10 . Moreover, the differences in the testing methodology employed and the extent of its regulation may also have been the factors contributing to the observed differences 10 .…”

Section: Resultsmentioning

confidence: 99%

“…A study from Punjab reveals highest prevalence (49.81%) of Hepatitis C infection within the age group 41-60 years, followed by 30.04% within the age group 21-40 years, with the lowest prevalence was observed within the age group of years >80 (0.39%) and ≤20 (1.74%) 9 . While study from Delhi reported maximum seroprevalence of anti-HCV antibodies in the age group of 18 to 30 yr (0.41%) and the minimum in the age group of 51 to 60 yr (0.26%) 10 .…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of Hepatitis C among Voluntary Blood Donors in Mumbai

Narayankar¹,

Maindad²

2016

jmscr

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Hepatitis C among Voluntary Blood Donors in Mumbai

Narayankar¹,

Maindad²

2016

jmscr

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“…Amongst the general patient factors, the recipient's age and body surface area were identified as an independent predictors of the amount of RBCs transfused, the latter being proved in patients receiving a living donor transplant [18,19]. In addition, the impact of the severity of the disease assessed with the Child-Pugh score and Model of End-Stage Liver Disease (MELD) score was frequently studied, yielding inconsistent results.…”

Section: Recipient-related Predictors Of Blood Transfusionmentioning

confidence: 99%

Perioperative bleeding in patients undergoing liver transplantation

Starczewska

Giercuszkiewicz²,

Niewiński³

et al. 2016

Anaesthesiol Intensive Ther

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Liver transplantation (LT) remains one of the most challenging surgical procedures. For many years uncontrolled bleeding and catastrophic haemorrhages were one of the major causes of perioperative mortality and morbidity. During the past fifty years, significant progress in surgical technique and perioperative management has led to a marked change in transfusion practice over time, where up to 79.6% of LTs in experienced transplant centers are performed without any blood product transfusion. Despite this, perioperative bleeding and transfusion requirements remain potent predictors of patient's mortality, as well as postoperative complications and graft survival. The major impact of blood product transfusion on LT recipients outcomes implies that all patients on waiting lists should be carefully screened for the presence of risk factors of perioperative bleeding. Although multiple predictors of transfusion requirements during recipients have been identified, no predictive model validated across centers has been constructed. The most suitable strategies to reduce intraoperative blood loss in this group should be employed on a case-to-case basis. This paper aims to summarize the most up-to-date evidence in the management of haemostasis in LT recipients.Key words: liver transplantation, perioperative management, haemostasis, bleeding Anaesthesiology Intensive Therapy 2016, vol. 48, no 1, 34-40 Liver transplantation (LT) remains one of the most challenging surgical technique. For many years, uncontrolled bleeding and catastrophic haemorrhages were one of the major causes of perioperative mortality and morbidity. During more than the fifty years of experience gained since the first LT was performed by Thomas Starzl in 1963, an improvement in surgical techniques and anaesthetic management has led to a marked change in transfusion practices over time. A recently published retrospective analysis of data from the Mayo Clinic in Rochester has shown that over the last two decades there has been a significant decrease in the amount of perioperatively transfused red blood cells (RBCs), fresh frozen plasma (FFP), platelets, cryoprecipitate and intraoperative autotransfusions [1]. Interestingly, this was noted despite the fact that transfusion triggers remained the same over time [1]. Massicotte et al. [2] reported that currently up to 79.6% of LTs are performed without any blood product transfusion. The major impact of blood product transfusion on LT recipient outcomes implies that all patients on waiting lists should be carefully screened for the presence of risk factors of perioperative bleeding. The most suitable strategies to reduce intraoperative blood loss in this group should be employed on a case-to-case basis. This paper aims to summarize the most up-to-date evidence in management of haemostasis in LT recipients. HAEMOSTATIC ALTERATIONS IN LIVER TRANSPLANT RECIPIENTSThe change in transfusion practices was possible due to a better understanding of alterations in the haemostatic system in LT recipients. The l...

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