Nutritional Status Influences Oxidative Stress and Insulin Resistance in Preschool Children

Fuentes-Venado, Claudia Erika; Terán-Pérez, Guadalupe; Espinosa-Hernández, Víctor Manuel; Martínez‐Herrera, Erick; Segura-Uribe, Julia J.; Mercadillo, Roberto E.; Pinto‐Almazán, Rodolfo; Guerra‐Araiza, Christian

doi:10.1089/met.2021.0021

Cited by 7 publications

(5 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For parameters of OS (F2-isoprostanes and oxidized LDL), the relationship was weaker after taking into account BMI values [ 30 ]. In obese children aged 3 to 6 years, selected parameters of OS, such as MDA, SOD, and 3-nitrotyrosine (3-NT), are positively correlated with BMI [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…MnSOD activity is significantly decreased in obese children aged 8-16 years old when compared to normal-weight children [ 42 ]. On the other hand, Fuentes-Venado et al documented recently that SOD activity is significantly increased in obese children (3–6 years old) when compared to normal-weight children [ 31 ]. According to Dzięgielewska-Gęsiak et al, there is no significant difference in CuZnSOD activity in erythrocytes between healthy elderly subjects with and without IR [ 43 ], but CuZnSOD activity in erythrocytes was shown to be significantly decreased in elderly individuals with prediabetes [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…A prerequisite for the diagnosis of MS is that at least three of the following criteria are met: (1) central obesity defined as increased WC (cut-off values for male and female gender differ between populations and countries); (2) systolic BP (SBP) ≥ 130 mmHg or diastolic BP (DBP) ≥ 85 mmHg, or taking antihypertensive drugs by a patient with diagnosed arterial hypertension; (3) TG ≥ 150 mg/dL (1.7 mmol/L) or pharmacological treatment of this lipid disorder; (4) HDL-C < 40 mg/dL in men or < 50 mg/dL in women, or pharmacological treatment for this lipid disorder; (5) fasting venous blood plasma glucose concentration ≥ 100 mg/dL, or pharmacological treatment of diagnosed carbohydrate metabolism disorders [22]. (14); atopic skin disease (2); bipolar disorder or depression (3); cholelithiasis (1); chronic gastritis (1); coeliac disease (1); colitis (2); Crohn's disease (1); diabetes mellitus (1); epilepsy (2); history of gastric ulcers (1); GERD (7); gout (2); Hashimoto's disease and hypothyroidism (31); hypercholesterolemia treated with statins (1); hyperprolactinemia (1); hypertension (13); idiopathic purpura (1); irritable bowel syndrome (5); lactation (1); lactose intolerance (1); Marfan syndrome (1); migraines (3); nephrolithiasis (3); non-infectious hepatitis (1); polycystic ovarian disease (9); psoriasis (2); steatosis hepatitis (1); virial hepatitis (3).…”

Section: Diagnosis Of the Metabolic Syndromementioning

confidence: 99%

See 2 more Smart Citations

“Obesity and Insulin Resistance” Is the Component of the Metabolic Syndrome Most Strongly Associated with Oxidative Stress

et al. 2021

View full text Add to dashboard Cite

Metabolic syndrome (MS) is not a homogeneous entity, but this term refers to the coexistence of factors that increase the risk for the development of type 2 diabetes and cardiovascular disease. There are different versions of the criteria for the diagnosis of MS, which makes the population of patients diagnosed with MS heterogeneous. Research to date shows that MS is associated with oxidative stress (OS), but it is unclear which MS component is most strongly associated with OS. The purpose of the study was to investigate the relationship between the parameters of OS and the presence of individual elements of MS in young adults, as well as to identify the components of MS by means of principal components analysis (PCA) and to investigate how the parameters of OS correlate with the presence of individual components. The study included 724 young adults with or without a family history of coronary heart disease (population of the MAGNETIC study). Blood samples were taken from the participants of the study to determine peripheral blood counts, biochemical parameters, and selected parameters of OS. In addition, blood pressure and anthropometric parameters were measured. In subjects with MS, significantly lower activity of superoxide dismutase (SOD), copper- and zinc-containing SOD (CuZnSOD), and manganese-containing SOD (MnSOD) were found, along with significantly higher total antioxidant capacity (TAC) and significantly lower concentration of thiol groups per gram of protein (PSH). We identified three components of MS by means of PCA: “Obesity and insulin resistance”, “Dyslipidemia”, and “Blood pressure”, and showed the component “Obesity and insulin resistance” to have the strongest relationship with OS. In conclusion, we documented significant differences in some parameters of OS between young adults with and without MS. We showed that “Obesity and insulin resistance” is the most important component of MS in terms of relationship with OS.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Diagnosis Of the Metabolic Syndromementioning

confidence: 99%

See 1 more Smart Citation

“Obesity and Insulin Resistance” Is the Component of the Metabolic Syndrome Most Strongly Associated with Oxidative Stress

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Meanwhile, CAT concentration and the GSH/oxidized glutathione (GSSG) ratio correlated negatively with BMI. However, in children with overweight, SOD, CAT, and GSH/GSSG all correlated negatively with BMI [88]. In male and female patients with MS, the levels of oxidative markers, substances reactive to thiobarbituric acid and carbonyl protein, were increased, while the non-enzymatic antioxidants vitamin C and GSH were decreased [89].…”

Section: Evidence From Human Studiesmentioning

confidence: 92%

“…In the study by Aasheim and Bohmer [95], morbidly obese male and female patients have the most noticeable reduction in vitamins A, B6, C, D, and E. The cross-sectional study of Barzegar-Amini et al [96] showed a significantly lower serum level of vitamin E in male and female patients with MS than patients without MS. Low carotenoids, vitamins C and E are related to increased BMI [97][98][99]. Erythrocytes of obese women Cu/Zn-SOD, CAT, GPx activities Decreased [86] Serum of male and female T2DM patients GSH content/GPx, GR activities Decreased [32] Adipose tissue of obese and/or T2DM male and female patients Mn-SOD, GPx activities Decreased [87] Serum and liver of male and female NAFLD patients GSH level Decreased [33] Peripheral blood mononuclear cells of obese children of both sexes Mn-SOD, CAT expression Decreased [34] Serum of MS male and female patients Vitamin E concentration Decreased [96] Blood samples of obese and overweight children SOD activity/GSH/GSSG ratio, CAT activity Increased/decreased (in obese); all decreased (in overweight) [88] Blood samples of MS male and female patients Vitamin C, GSH levels Decreased [89] NAFLD: non-alcoholic fatty liver disease…”

Section: Evidence From Human Studiesmentioning

confidence: 99%

Oxidative stress in obesity and insulin resistance

Panic

Stanimirović

Sudar-Milovanović

et al. 2022

Exploration of Medicine

View full text Add to dashboard Cite

Since obesity is one of the main factors in the development of insulin resistance (IR) and is also associated with increased oxidative stress (OxS) rate, this study aims to review the published literature to collate and provide a comprehensive summary of the studies related to the status of the OxS in the pathogenesis of obesity and related IR. OxS represents an imbalance between the production of reactive oxygen and nitrogen species (RONS) and the capacity of the antioxidant defense system (AOS) to neutralize RONS. A steady-state of RONS level is maintained through endogenous enzymatic and non-enzymatic AOS components. Three crucial enzymes, which suppress the formation of free radicals, are superoxide dismutases, catalases, and glutathione peroxidases. The second line of AOS includes non-enzymatic components such as vitamins C and E, coenzyme Q, and glutathione which neutralizes free radicals by donating electrons to RONS. Emerging evidence suggests that high RONS levels contribute to the progression of OxS in obesity by activating inflammatory pathways and thus leading to the development of pathological states, including IR. In addition, decreased level of AOS components in obesity increases the susceptibility to oxidative tissue damage and further progression of its comorbidities. Increased OxS in accumulated adipose tissue should be an imperative target for developing new therapies in obesity-related IR.

show abstract

The combined effects of overweight/obesity and dietary antioxidant quality score on hypertension in children and adolescents

Zhong,

Zhang,

2023

BMC Pediatr

View full text Add to dashboard Cite

Background This study was to evaluate the combined effects of overweight/obesity and DAQS on the risk of hypertension in children and adolescents. Methods In this cross-sectional study, the data of 14,316 subjects were extracted from the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression analysis was used to explore the associations of obesity and DAQS with the risk of hypertension. The combined effect of overweight/obesity and DAQS on the risk of hypertension was evaluated. Results Body mass index (BMI)-for-age < 85th percentile was associated with reduced risk of hypertension in children and adolescents [odds ratio (OR) = 0.48, 95% confidence interval (CI): 0.41–0.62]. No significant association between DAQS ≥ 3 and the risk of hypertension before and after the adjustment of confounders (P > 0.05). Subjects with BMI-for-age of < 85th percentile and DAQS < 3 was associated with decreased risk of hypertension (OR = 0.53, 95%CI: 0.35–0.79). People with BMI-for-age of < 85th percentile and DAQS ≥ 3 was correlated with decreased risk of hypertension (OR = 0.52, 95%CI: 0.36–0.74). Subgroup analysis revealed that in subjects aged ≥ 12 years, decreased risk of hypertension was observed in BMI-for-age < 85th percentile and DAQS < 3 group (OR = 0.48, 95%CI: 0.31–0.73) as well as BMI-for-age < 85th percentile and DAQS ≥ 3 group (OR = 0.47, 95%CI: 0.32–0.67). In boys, BMI-for-age < 85th percentile and DAQS < 3 group (OR = 0.45, 95%CI: 0.25–0.81) as well as BMI-for-age < 85th percentile and DAQS ≥ 3 group (OR = 0.40, 95%CI: 0.25–0.65) were correlated with decreased risk of hypertension. Conclusion Overweight/obesity and DAQS had combined effects on the risk of hypertension in children and adolescents, which implied that for children and adolescents with normal weight, to keep normal weight combined with high quality of diet might be recommended.

show abstract

Nutritional Status Influences Oxidative Stress and Insulin Resistance in Preschool Children

Cited by 7 publications

References 63 publications

“Obesity and Insulin Resistance” Is the Component of the Metabolic Syndrome Most Strongly Associated with Oxidative Stress

“Obesity and Insulin Resistance” Is the Component of the Metabolic Syndrome Most Strongly Associated with Oxidative Stress

Oxidative stress in obesity and insulin resistance

The combined effects of overweight/obesity and dietary antioxidant quality score on hypertension in children and adolescents

Contact Info

Product

Resources

About