Oxidative stress in obesity and insulin resistance

Panic, Anastasija; Stanimirović, Julijana; Sudar-Milovanović, Emina; Isenović, Esma R.

doi:10.37349/emed.2022.00074

Cited by 11 publications

(3 citation statements)

References 99 publications

(128 reference statements)

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“…Reports showed that leptin and insulin resistance play a vital role in the development of obesity [ 34 , 35 , 36 ]. Additionally, there was a strong positive correlation among insulin resistance, oxidative stress and inflammation [ 37 , 38 ]. Dietary tannic acid, as an antioxidant, effectively improved the liver oxidative damage caused by a high-fat diet ( Figure 3 A).…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet

Fang

Zeng

et al. 2022

Foods

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Dietary tannic acid, as a natural polyphenolic, has many important biological activities. This study aimed to investigate the effect of dietary tannic acid on obesity and gut microbiota in mice with a high-fat diet. Male C57BL/6J mice fed a high-fat diet were treated with dietary tannic acid for eight weeks. Results showed that dietary tannic acid reduced the body weight gain, regulated glycolipid metabolism, improved the insulin resistance, and attenuated the liver oxidative stress in high-fat diet-fed mice. Moreover, both dietary tannic acid intervention groups repaired the gut barrier damage caused by a high-fat diet, especially in the 50 mg/kg/d dietary tannic acid intervention group. Interestingly, the effect of dietary tannic acid on serum endotoxin lipopolysaccharide (LPS) content was correlated with the abundance of the LPS-producing microbiota. In addition, dietary tannic acid altered the abundance of obesity-related gut microbiota (Firmicutes, Bacteroidetes, Bacteroides, Alistipes, and Odoribacter) in the 150 mg/kg/d dietary tannic acid intervention group, while it was not effective in the 50 mg/kg/d dietary tannic acid intervention group. These findings suggested the potential effect of dietary tannic acid for the prevention and control of obesity.

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Section: Discussionmentioning

confidence: 99%

Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet

Fang

Zeng

et al. 2022

Foods

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“…503 Notably, the oxidative stress involved in insulin resistance needs to be considered. 504 Chronic kidney disease (CKD). Erythropoiesis-stimulating agents (ESAs) and prolyl hydroxylase inhibitors (PHIs) are commonly used to treat CKD.…”

Section: Hypoxia-targeted Therapeutics In Cancer and Tumormentioning

confidence: 99%

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Luo

Tian

Yang³

et al. 2022

Sig Transduct Target Ther

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Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is linked to several biological processes, including pathogenic microbe infection, metabolic adaptation, cancer, acute and chronic diseases, and other stress responses. The mechanism underlying cells respond to oxygen changes to mediate subsequent signal response is the central question during hypoxia. Hypoxia-inducible factors (HIFs) sense hypoxia to regulate the expressions of a series of downstream genes expression, which participate in multiple processes including cell metabolism, cell growth/death, cell proliferation, glycolysis, immune response, microbe infection, tumorigenesis, and metastasis. Importantly, hypoxia signaling also interacts with other cellular pathways, such as phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling, nuclear factor kappa-B (NF-κB) pathway, extracellular signal-regulated kinases (ERK) signaling, and endoplasmic reticulum (ER) stress. This paper systematically reviews the mechanisms of hypoxia signaling activation, the control of HIF signaling, and the function of HIF signaling in human health and diseases. In addition, the therapeutic targets involved in HIF signaling to balance health and diseases are summarized and highlighted, which would provide novel strategies for the design and development of therapeutic drugs.

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“…Raised levels of circulatory glucose and lipids increase the energy substrates delivered to cellular metabolic pathways, thereby enhancing the production of reactive oxygen species. Excessive adipose mass is a source of pro-inflammatory cytokines which in turn increase ROS production and lipid peroxidation, leading to oxidative stress 38 . Significantly increased levels of malondialdehyde (MDA), the stable end product of lipid peroxidation, observed in the liver tissues of HFD-induced untreated obese rats than normal diet fed rats is the marker for generation of HFD induced oxidative stress in the present study.…”

Section: Pharmaceutical Sciences Asiamentioning

confidence: 99%

Anti-obesity potential of Capparis spinosa flower bud extracts in 3T3-L1 adipocytes and in high fat diet induced obese rats

Athesh¹,

Brindha²

2022

Pharm Sci Asia

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Obesity is a raising pandemic and it needs alternative approaches to prevent or treat, as the existing approaches are not highly effective. In this context, the present study has been designed with the aim to investigate the antiobesity potential of aqueous flower buds extract of Capparis spinosa L. (AFBECS) in 3T3-L1 adipocytes and in high fat diet (HFD) induced obesity thereby giving scientific validation to its traditional use. The 3T3-L1 preadipocytes were cultured and differentiated in DMEM in the absence and presence of various concentrations of AFBECS (25, 50, 100, 250 and 500 µg/mL) and the influence of the extracts on 3T3-L1 adipocyte viability and lipid accumulation were determined. The results showed that AFBECS maintained the viability of the 3T3-L1 adipocytes and also reduced the lipid accumulation in 3T3-L1 cells, dose dependently. In-vitro pancreatic lipase inhibition assay of AFBECS had shown moderate level of inhibition when compared with Orlistat. For in-vivo studies, HFD induced obese rats were treated with 100, 200 and 300 mg/kg of extracts for a period of 60 days using orlistat as standard drug. Anti-obesity potential was assessed using food intake, body weight, organ weights, adipocyte area, lipid profiles and many other blood biochemical parameters. Data of in-vivo studies revealed, significant reduction in body weight, fat-pad and organ weights of AFBECS treated animals. Altered levels of glucose, insulin, leptin, lipid profiles and antioxidant status were also normalized upon AFBECS treatment. These findings suggested that AFBECS was found to have prominent anti-obesity potential and exhibited its therapeutic efficacy by inhibiting adipogenesis, promoting lipolysis and ameliorating oxidative stress.

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Oxidative stress in obesity and insulin resistance

Cited by 11 publications

References 99 publications

Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet

Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Anti-obesity potential of Capparis spinosa flower bud extracts in 3T3-L1 adipocytes and in high fat diet induced obese rats

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