Nutritional status in relation to adipokines and oxidative stress is associated with disease activity in patients with rheumatoid arthritis

Hayashi, Hitomi; Satoi, Keiko; Sato-Mito, Natsuko; Kaburagi, Tomoko; Yoshino, Haruka; Higaki, Megumu; Nishimoto, Keiji; Sato, Kazuto

doi:10.1016/j.nut.2012.02.009

Cited by 45 publications

(36 citation statements)

References 28 publications

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“…Previous studies have consistently reported that levels of SFA in plasma phosphatidylcholine [31] and adipose tissue [19] are significantly higher in patients with RA than in healthy controls. SFA was particularly effective in recruiting and activating immune cells, thereby increasing inflammation [32] and serum TNF-α [33] levels in patients with RA. Additionally, consumption of trans fatty acids has been known to increase proinflammatory cytokines [34] via TNF system activity as well as other plasma cytokines [35] and their soluble receptors [34].…”

Section: Discussionmentioning

confidence: 99%

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

Lee

Park

2013

Ann Nutr Metab

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Background: Rheumatoid arthritis (RA) is one of the most common autoimmune diseases that result in chronic inflammation of the joints. n-3 polyunsaturated fatty acids (PUFAs) have been suggested to play a role in the pathogenesis and clinical course of RA. The purpose of the present study was to investigate whether erythrocyte levels of n-3 PUFA are associated with an increased risk of RA and whether this could potentially serve as an indicator of RA disease activity in Korean women. Methods: A total of 100 female RA patients and 100 healthy women were enrolled into this study. Erythrocyte fatty acid composition and RA disease activity were evaluated in all patients. Results: Erythrocyte levels of α-linolenic acid (ALA; 18:3n3), eicosapentaenoic acid (EPA; 20:5n3), and the omega-3 index [EPA + docosahexaenoic acid (DHA)] were significantly lower in RA patients than in healthy controls. Multivariable-adjusted regression analysis showed that the levels of ALA, EPA, and the ratio of EPA to arachidonic acid were negatively associated with the risk of RA after adjusting for body weight and smoking status. Additionally, the concentration of prostaglandin E₂ was significantly decreased with increased levels of erythrocyte DHA among RA patients. Conclusions: Erythrocyte levels of EPA and ALA were negatively associated with the risk of RA in Korean women, which may be related to eicosanoid metabolism.

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Section: Discussionmentioning

confidence: 99%

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

Lee

Park

2013

Ann Nutr Metab

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“…Positive correlation Serum leptin has a significant association with LDL cholesterol levels, which can predict radiographic progression of RA Muraoka et al [18] Hayashi et al [19] 2012 n.a.…”

Section: Serum Leptin Levels Increasementioning

confidence: 99%

“…Leptin comes mainly from adipose cells. Most studies have found significantly elevated serum levels of leptin in RA patients [7,18,22,[26][27][28]30,36,40,92,93], while others have found decreased levels [19,21,32,34]. Although the relationship is complex, leptin has been shown to be the major factor linkage of food intake with bone metabolism [94].…”

Section: Leptin and Rheumatoid Arthritismentioning

confidence: 99%

Emerging role of leptin in rheumatoid arthritis

Tian

Liang

Wang

et al. 2014

Clinical and Experimental Immunology

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SummaryNumerous studies have suggested the importance of leptin against autoimmune diseases such as systemic lupus erythematosus (SLE), multiple sclerosis (MS) and psoriasis. To summarize our current understanding of the role of leptin in inflammatory responses and rheumatoid arthritis (RA), a systematic review was conducted to assess the discrepancy of leptin in RA and its effect on immunity according to different studies. Recently, emerging data have indicated that leptin is involved in the pathological function of RA, which is common in autoimmune disorders. This review discusses the possible consequences of leptin levels in RA. Blocking the key signal pathways of leptin and inhibiting the leptin activity-like leptin antagonist may be a promising way for potential therapeutic treatment of RA at risk of detrimental effects. However, leptin was increased in patients with RA and may also regulate joint damage. Thus, more understanding of the mechanism of leptin in RA would be advantageous in the future.

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“…One of the studies showed that dietary intakes of MUFA and fish oil correlated with the suppression of the inflammatory status. In contrast, larger intakes of w-6/w-3 and saturated fatty acid correlated to promoted inflammatory status [18]. In another study, both men and women with active rheumatoid arthritis ingested significantly less energy from CHO and more energy from fat.…”

Section: Discussionmentioning

confidence: 91%

The Effect of Anti TNF-Alpha Therapy in Nutritional Status and Serum Leptin Levels in Patients with Ankylosing Spondylitis

Zehra¹,

Makbule²,

Mesut³

2017

IJCN

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The objective of this study was to investigate the effect of anti TNF-α therapy on nutritional status and serum leptin levels in patients with ankylosing spondylitis. This study was conducted on two groups of AS patients. First group included 48 patients receiving anti TNF-α treatment together with NSAID. Second group included 48 patients receiving only NSAID treatment. Descriptive information, food consumption and physical activity about patients collected with a survey. Anthropometric measurements were measured with body analysis scale and serum leptin was also assessed. As results, there was significant difference in daily energy consumption between both men and women with and without anti TNF-α treatment (2399 kcal and 2069 kcal p=0,036, 2102 kcal and 1659 kcal p=0,001). There was no significant difference of serum leptin levels between patients receiving anti TNF-α and only NSAID treatment (p>0,05). However, the women's leptin levels (12,4±8,2 ng/mL) were significantly higher compared to men (3,7±3,02 ng/mL). There was positive correlation of serum leptin levels, BMI and body fat mass between men and women with and without anti TNF-α treatment. The anthropometric measurements between both men and women groups were not significant (p>0,05). No statistical difference was found between the physical activity assessments of the groups (p>0,05). In conclusion, there was no significant effect of anti-TNF-α treatment in AS patients on serum leptin levels, physical activity, and anthropometric measurements. However, anti TNF-α therapy receiving patients' daily energy and nutrient consumption were higher. This study showed anti TNF-α therapy has been effective on food consumption of patients with ankylosing spondylitis.

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Nutritional status in relation to adipokines and oxidative stress is associated with disease activity in patients with rheumatoid arthritis

Cited by 45 publications

References 28 publications

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

The Association between n-3 Polyunsaturated Fatty Acid Levels in Erythrocytes and the Risk of Rheumatoid Arthritis in Korean Women

Emerging role of leptin in rheumatoid arthritis

The Effect of Anti TNF-Alpha Therapy in Nutritional Status and Serum Leptin Levels in Patients with Ankylosing Spondylitis

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