Nutritional status, especially body mass index, from birth to adulthood and lung function in young adulthood

Ubilla, Carlos; Bustos, Patricia; Amigo, Hugo; Oyarzún, M; Rona, Roberto J.

doi:10.1080/03014460801978937

Cited by 25 publications

(31 citation statements)

References 27 publications

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“…Possibly this is because birth weight is the most available measure in many datasets. One cohort used multiple measures including BMI at birth and 1 year to predict adult spirometry 16. In keeping with this report, we found birth weight to be an equivalent or better predictor of adult lung function than some other measures of birth size, including length.…”

Section: Discussionsupporting

confidence: 84%

“…One study found that adult FEV 1 and FVC were positively associated with weight gain in the first year of life although the effect on FEV 1 was not statistically significant in men 10. However, another cohort found that growth in the first year of life was not related to adult lung function 16. Other studies have reported that greater postnatal weight gain is associated with lower lung function in infancy 17 18…”

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confidence: 99%

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Associations between birth weight, early childhood weight gain and adult lung function

Hancox

Poulton

Greene

et al. 2009

Thorax

117

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Background: Low birth weight is associated with lower values for spirometry in adults but it is not known if birth weight influences other measures of pulmonary function. It is also unclear whether postnatal growth affects adult lung function. The associations between birth weight, postnatal growth and adult lung function were assessed in an unselected birth cohort of 1037 children. Methods: Birth weight, weight gain between birth and age 3 years, and lung function at age 32 years were measured. Analyses were adjusted for adult height and sex and further adjusted for multiple other potential confounding factors. Results: Birth weight was positively correlated with spirometric (forced expiratory volume in 1 s and forced vital capacity) and plethysmographic (total lung capacity and functional residual capacity) lung function and with lung diffusing capacity. These associations persisted after adjustment for confounding factors including adult weight, exposure to cigarette smoke in utero and during childhood, personal smoking, socioeconomic status, asthma and gestational age. Weight gain between birth and age 3 years was also positively associated with lung diffusing capacity, and with higher values of lung volumes in men after adjustment for covariates. Neither birth weight nor postnatal weight gain was associated with airflow obstruction. Conclusions: Low birth weight and lower weight gain in early childhood are associated with modest reductions in adult lung function across a broad range of measures of lung volumes and with lower diffusing capacity. These findings are independent of a number of potential confounding factors and support the hypothesis that fetal and infant growth is a determinant of adult lung function.

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Section: Discussionsupporting

confidence: 84%

mentioning

confidence: 99%

Associations between birth weight, early childhood weight gain and adult lung function

Hancox

Poulton

Greene

et al. 2009

Thorax

117

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“…Reductions in FEV 1 and FVC have been documented in extremely obese subjects, as well as a reduction in lung volume 17,18. Both BMI and weight gain have been associated with declines in lung function in the general population 19–21. A large cross-sectional, population-based study conducted in France concluded that abdominal obesity was the strongest predictor of lung-function impairment (odds ratio [OR] 1.94, 95% confidence interval [CI] 1.80–2.09; and OR 2.1, 95% CI 1.95–2.29; for FEV 1 and FVC, respectively) 22.…”

Section: The Association Between Obesity and Copdmentioning

confidence: 99%

Influence of diet and obesity on COPD development and outcomes

Hanson¹,

Rutten²,

Wouters³

et al. 2014

COPD

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The global increase in the prevalence and incidence of obesity has called serious attention to this issue as a major public health concern. Obesity is associated with many chronic diseases, including cardiovascular disease and diabetes, and recently the role of overweight and obesity in lung disease has received new interest. Independently of obesity, diet also plays a role as a risk factor for many chronic diseases, and evidence is accumulating to support a role for diet in the prevention and management of several lung diseases. Chronic obstructive lung disease is the third-leading cause of death globally, and both obesity and diet appear to play roles in its pathophysiology. Obesity has been associated with decreased lung-function measures in population-based studies, with increased prevalence of several lung diseases and with compromised pulmonary function. In contrast, obesity has a protective effect against mortality in severe chronic obstructive pulmonary disease (COPD). Nutrient intake and dietary patterns have also been associated with lung-function measures and the development and progression of COPD. Taken together, this suggests that a focus on obesity and diet should be part of public health campaigns to reduce the burden of lung disease, and could have important implications for clinicians in the management of their patients. Future research should also focus on elucidating these relationships in diverse populations and age-groups, and on understanding the complex interaction between behavior, environment, and genetics in the development and progression of COPD. The goal of this article is to review current evidence regarding the role that obesity and diet play in the development of COPD, and in COPD-related outcomes.

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“…All studies were in English and all 18 articles reported associations for FVC, while only 10 also reported FEV1/FVC. One article reported results from two different study populations (17) and five reported results for males and females separately (18)(19)(20)(21)(22), so the total number of comparisons was 24 for FVC and 14 for FEV1/FVC ( Figure E1). Birth weight was investigated in all 18 studies, whereas there was only one for weight at one year and another one for weight gain in the first year of life.…”

Section: Inclusion and Exclusion Of Studiesmentioning

confidence: 99%

Birth Weight and Lung Function in Adulthood: A Systematic Review and Meta-analysis

et al. 2017

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At a Glance CommentaryScientific knowledge on the subject: Increasing evidence supports the influence of early life factors on later lung function, which might prevent individuals from attaining maximum lung function and predispose them to increased risk of lung disease in later life.What this study adds to the field: This is the first systematic review and meta-analysis on the association of birth weight, weight at one year and weight gain in the first year of life with lung function measures of both restrictive and obstructive patterns in adulthood. We convincingly show a positive association between birth weight and restrictive impairment (low FVC), with findings consistent across studies. The meta-analysis for birth weight and airflow obstruction (low FEV1/FVC) might suggest a positive association but the evidence is much weaker. We identified gaps and limitations in the current evidence that should be addressed in future research.This article has an online data supplement, which is accessible from this issue's table of content online at www.atsjournals.org. 3 AbstractRationale: There is evidence suggesting that birth weight may influence lung function in adulthood, but it is unclear whether it might differentially affect restrictive (FVC) and obstructive (FEV1/FVC) patterns.Objectives: To summarize evidence available on the association of birth weight, weight at one year and weight gain in the first year of life with FVC and FEV1/FVC in adulthood. Methods:We performed a systematic review of the literature by searching MEDLINE, EMBASE and Web of Science through January 2015. Data were combined using inversevariance weighted meta-analysis with random effects models, and between-study heterogeneity evaluated. We conducted a priori subgroup or sensitivity analyses by age, country wealth, ethnicity, sex and smoking. Risk of bias was evaluated using the Newcastle-Ottawa Scale, and reporting bias using funnel plots. Measurements and Main Results:Eighteen articles were included in the review, and 13 in the meta-analyses. Most studies were from high-income countries, and all showed low risk of bias.We found strong evidence of association of birth weight with adult FVC, a 59.4mL higher FVC in adulthood per kg increase in birth weight (95%CI: 43.3 to 75.5), with no evidence of heterogeneity. Evidence of an association of birth weight with FEV1/FVC was weaker and showed some inconsistency across studies. Only one study investigated weight at one year, and another one weight gain in the first year. Conclusions:Our meta-analyses show strong and consistent evidence of an association of birth weight with adult FVC, a measure of restrictive impairment, with much weaker evidence for airflow obstruction.

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Nutritional status, especially body mass index, from birth to adulthood and lung function in young adulthood

Abstract: BMI and waist circumference in adulthood make a greater impact on lung function in adulthood than anthropometric measurements at birth and infancy. Proxy measures of fatness in adulthood reduce lung function, but the pattern between fatness and lung function by sex may be different.

Cited by 25 publications

References 27 publications

Associations between birth weight, early childhood weight gain and adult lung function

Associations between birth weight, early childhood weight gain and adult lung function

Influence of diet and obesity on COPD development and outcomes

Birth Weight and Lung Function in Adulthood: A Systematic Review and Meta-analysis

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