Nutritional status at hospital admission and prediction of clinical outcomes in children and adolescents with cancer: Results of the Brazilian survey on oncological nutrition in paediatrics

Afonso, Wanélia Vieira; Peres, Wilza Arantes Ferreira; Pinho, Nivaldo Barroso de; Schilithz, Arthur Orlando Corrêa; Martucci, Renata Brum; Rodrigues, V.D.; Braga, Juliana Silva do Nascimento; Costa, Joana Dias da; Padilha, Patrícia de Carvalho

doi:10.1111/jhn.13153

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Since cancer patients are less active than healthy children, increased requirements could be compensated by decreased needs for physical activity. A temporary stagnation in growth and alterations in body composition with a decrease in metabolically active tissue (fat-free mass) in children with cancer also seem to play a role [ 9 , 10 , 11 , 12 , 13 ].…”

Section: Macronutrients and Energy Requirementsmentioning

confidence: 99%

Recommendations for Nutritional Supplementation in Pediatric Oncology: A Compilation of the Facts

et al. 2023

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Background: As one of the few modifiable risk factors, the importance of dietary patterns for both disease prevention and treatment outcome in pediatric oncology has gained increasing popularity. Malnutrition is associated with lower survival rates, tolerance to treatment, and quality of life. Yet, especially in children with malignancies, nutritional deterioration is common, and pediatric cancer patients often present with inadequate intake of micro- and macronutrients alike. Despite the reported widespread use of dietary supplements, few empirical data provide a basis for clinical recommendations, and evidence for their efficacy is inconsistent. Current literature lacks a systematic approach as to how and which supplements should be recommended for specific patients, types of cancer, or during specific treatments. The aim of this review is to highlight the role of the most frequently used nutrients in pediatric malignant diseases and to give a practical guide based on current scientific evidence. Methods: A comprehensive literature search was conducted on PubMed through April 2023 to select meta-analyses, systematic reviews, observational studies, and individual randomized controlled trials (RCTs) of macro- and micronutrient supplementation in pediatric oncology. The search strategy included the following medical subject headings (MeSH) and keywords: “childhood cancer”, “pediatric oncology”, “nutritional status”, “dietary supplements”, “vitamins”, “micronutrients”, “calcium”, “magnesium”, “vitamin D”, “zinc” “glutamine”, “selen”, and “omega-3 fatty acids”. The reference lists of all relevant articles were screened to include potentially pertinent studies. Results: The present review provides a comprehensive and updated overview of the latest evidence about the role of nutrition and diet in pediatric oncology, also focusing on different nutritional interventions available for the management of the disease. We summarize evidence about the importance of adequate nutrition in childhood cancer and the role of several micronutrients and critically interpret the findings. Possible effects and benefits of supplementation during chemotherapy are discussed, as are strategies for primary and secondary prevention. Conclusions: We here describe the obvious benefits of dietary supplementation for childhood cancer. Further large-scale clinical trials are required to verify the impacts of deficiencies and the possible benefits of supplementation and optimal dosages. (337 words).

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Section: Macronutrients and Energy Requirementsmentioning

confidence: 99%

Recommendations for Nutritional Supplementation in Pediatric Oncology: A Compilation of the Facts

et al. 2023

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Physical Development Characteristics of Children Treated for Brain Tumor and Healthy Siblings Of Cancer Patients (A Pilot Study)

Likhomanova,

Gorbacheva,

Kovaleva

et al. 2024

Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta Seria XXIII Antropologia)

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Introduction. In families with such a child his/her siblings often live, whose development will be affected by the current stressful situation for all family members. Siblings of cancer patients appear to be a psychological vulnerable group, as they have low self-esteem, fear of death and loneliness, anxiety, anger. The study aimed to assess the level of physical development (PD) of children, treated for brain tumors, and siblings of childhood cancer survivors, in relation to stressful circumstances of living in a family with an oncological relative. Material and methods. The study involved children aged 6 to 17 years who had completed treatment for a brain tumor (BT), as well as siblings of children with various cancer types. We measured 27 boys and 36 girls with BT, the sample of siblings included 26 boys and 31 girls. To assess the compliance of the level of PD of children of both groups with age standards, for each child of a given gender and age a centile corridor was determined by body length (BL) and BMI, and individual values of signs were ranked in Z-points, using WHO standards. A detailed questionnaire was conducted to assess some characteristics of a child's family environment. Statistics analysis was performed with Statistica 12 software package. Results. For a group of children with BT, a significant shift in the distribution of PD scores along body length and BMI towards low values was found, for a group of siblings, the opposite picture was obtained – the distribution of body length and BMI scores shifted to the higher values. It has been shown that higher developmental scores in body length are significantly more common in children who are older siblings in relation to patients with BT. Conclusion. Thus, brain tumor treatment affects not only the physical development of a child, but is a factor contributing to the growth processes of the body of siblings of children with BT. Siblings of cancer patients represent a special group of children, which indicates the need to take into account the special needs of all their family members in the process of treatment and rehabilitation, as well as the incorrectness of using siblings as a control group in scientific research.

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Nutritional status at hospital admission and prediction of clinical outcomes in children and adolescents with cancer: Results of the Brazilian survey on oncological nutrition in paediatrics

Cited by 2 publications

References 32 publications

Recommendations for Nutritional Supplementation in Pediatric Oncology: A Compilation of the Facts

Recommendations for Nutritional Supplementation in Pediatric Oncology: A Compilation of the Facts

Physical Development Characteristics of Children Treated for Brain Tumor and Healthy Siblings Of Cancer Patients (A Pilot Study)

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